Skeletal Muscle Function Is Dependent Upon BRCA1 to Maintain Genomic Stability [0.03%]
BRCA1依赖维持基因组稳定是骨骼肌功能的必要条件
Michael D Tarpey,Adam J Amorese,Elizabeth R LaFave et al.
Michael D Tarpey et al.
Breast Cancer gene 1 (BRCA1) is a large, multifunctional protein that regulates a variety of mechanisms in multiple different tissues. Our work established that Brca1 is expressed in skeletal muscle and localizes to the mitochondria and nuc...
Irene S Davis,Karsten Hollander,Daniel E Lieberman et al.
Irene S Davis et al.
Minimal footwear has existed for tens of thousands of years and was originally designed to protect the sole of the foot. Over the past 50 yr, most footwear has become increasingly more cushioned and supportive. Here, we review evidence that...
The Neurologist as an Agent of Exercise Rehabilitation in Multiple Sclerosis [0.03%]
神经科医生在多发性硬化症运动康复中的作用
Brian M Sandroff,Emma V Richardson,Robert W Motl
Brian M Sandroff
This review hypothesizes that the neurologist represents the linchpin of exercise behavior change within comprehensive multiple sclerosis (MS) care settings. This is based on a series of recent articles that developed actionable practice mo...
The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes [0.03%]
糖尿病患者胰岛素抵抗对运动时心血管控制的影响
Masaki Mizuno,Norio Hotta,Rie Ishizawa et al.
Masaki Mizuno et al.
Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural car...
Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication [0.03%]
骨骼肌Nrf2通过细胞外囊泡介导的信号通路参与运动诱导的机体抗氧化防御反应
Lie Gao,Han-Jun Wang,Changhai Tian et al.
Lie Gao et al.
This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins...
Wearable Monitors Facilitate Exercise in Adult and Pediatric Stem Cell Transplant [0.03%]
穿戴式监护仪可促进成人和儿童干细胞移植患者的运动
Ethan Pottebaum,Alexa Warmoth,Sabarish Ayyappan et al.
Ethan Pottebaum et al.
Hematopoietic stem cell transplant (HSCT) is a potentially curative treatment for hematopoietic malignancies, complicated by decreased performance status and quality of life. Exercise therapy improves outcomes in HSCT, but several barriers ...
Novel Insights Into Biarticular Muscle Actions Gained From High-Density Electromyogram [0.03%]
高密度肌电图所揭示的双关节肌肉作用的新见解
Kohei Watanabe,Taian Martins Vieira,Alessio Gallina et al.
Kohei Watanabe et al.
Biarticular muscles have traditionally been considered to exhibit homogeneous neuromuscular activation. The regional activation of biarticular muscles, as revealed from high-density surface electromyograms, seems however to discredit this n...
Kemal S Türker
Kemal S Türker
Although several methods have been used to estimate exercise-induced changes in human neuronal networks, there are growing doubts about the methodologies used. This review describes a single motor unit-based method that minimizes the errors...
A High-Fat Diet Aggravates the Age-Related Decline in Skeletal Muscle Structure and Function [0.03%]
高脂饮食加剧骨骼肌结构和功能的年龄相关性衰退
Hans Degens,Anandini Swaminathan,Jason Tallis
Hans Degens
The age-related decline in muscle function is aggravated by a high-fat diet (HFD)-induced increase in fat mass. The hypothesis is that an HFD leads to a faster accumulation of intramyocellular lipids (IMCL) and an earlier onset of muscle dy...
Role of Perivascular Adipose Tissue and Exercise on Arterial Function with Obesity [0.03%]
肥胖对动脉功能的影响及血管周围脂肪组织和运动的作用
Samuel Y Boateng,I Mark Olfert,Paul D Chantler
Samuel Y Boateng
Adipose tissue and arterial dysfunction are common in the obese state. Perivascular adipose tissue (PVAT) plays an important role in mediating arterial health, and with obesity, the PVAT dysfunction negatively affects arterial health. Exerc...