Eradication of HIV-1 from CNS reservoirs: current strategies and future priorities [0.03%]
消除HIV-1中枢神经系统储存库：当前策略和未来重点
Jeymohan Joseph
Jeymohan Joseph
Role of the macrophage in HIV-associated neurocognitive disorders and other comorbidities in patients on effective antiretroviral treatment [0.03%]
高效抗逆转录病毒治疗患者中巨噬细胞在人类免疫缺陷病毒感染相关神经认知障碍及其他合并症中的作用
Jay Rappaport,David J Volsky
Jay Rappaport
Combination antiretroviral therapy (ART) has altered the outcomes of HIV infection in treated populations by greatly reducing the incidence of opportunistic infections, cancer, and HIV-associated dementia. Despite these benefits, treated pa...
Human polyomavirus JC replication and non-coding control region analysis in multiple sclerosis patients under natalizumab treatment [0.03%]
那他珠单抗治疗多发性硬化症患者的JC多瘤病毒复制及非编码控制区域分析
Valeria Pietropaolo,Anna Bellizzi,Elena Anzivino et al.
Valeria Pietropaolo et al.
In the last years, the treatment of multiple sclerosis (MS) patients with natalizumab has been associated with the occurrence of progressive multifocal leukoencephalopathy (PML) caused by human polyomavirus JC (JCV). Here, we have shown a s...
Herpes simplex virus type 1 infection in neurons leads to production and nuclear localization of APP intracellular domain (AICD): implications for Alzheimer's disease pathogenesis [0.03%]
单纯疱疹病毒1型感染引起神经元产生并发生核定位的APP胞内样域：其对阿尔茨海默病发病机制的意义
Livia Civitelli,Maria Elena Marcocci,Ignacio Celestino et al.
Livia Civitelli et al.
Several data indicate that neuronal infection with herpes simplex virus type 1 (HSV-1) causes biochemical alterations reminiscent of Alzheimer's disease (AD) phenotype. They include accumulation of amyloid-β (Aβ), which originates from th...
Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults [0.03%]
新加坡甲型H1N1流感的神经病学特征：一项针对成人和儿童的大规模病例系列研究
Asha Prerna,Jocelyn Y X Lim,Natalie W H Tan et al.
Asha Prerna et al.
Neurologic complications have long been associated with influenza. A novel strain of influenza A (H1N1) first described in humans to have outbreak potential in 2009 in Mexico went on to become the first influenza pandemic of this century. W...
Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine [0.03%]
mirtazapine和mefloquine治疗下免疫缺陷病所引发的进行性多灶性白质脑病病情得到缓解
Rebekka Kurmann,Christian Weisstanner,Piotr Kardas et al.
Rebekka Kurmann et al.
Demonstration of survival and outcome of progressive multifocal leukoencephalopathy (PML) in a 56-year-old patient with common variable immunodeficiency, consisting of severe hypogammaglobulinemia and CD4+ T lymphocytopenia, during continuo...
Bovine herpesvirus 1 regulatory proteins are detected in trigeminal ganglionic neurons during the early stages of stress-induced escape from latency [0.03%]
应激诱导的牛疱疹病毒1型潜伏再活化早期三角神经节中检测到调控蛋白
Insun Kook,Alan Doster,Clinton Jones
Insun Kook
Bovine herpesvirus 1 (BHV-1) establishes latency in sensory neurons. The synthetic corticosteroid dexamethasone consistently induces reactivation from latency. Within 90 min after latently infected calves are treated with dexamethasone, two...
Adult-onset subacute sclerosing panencephalitis manifesting as slowly progressive dementia [0.03%]
成人发病亚急性硬化性全脑炎表现为进行性痴呆
Adalberto Studart Neto,Paulo Ribeiro Nóbrega,Maria Irma Seixas Duarte et al.
Adalberto Studart Neto et al.
Effects of cytomegalovirus infection in human neural precursor cells depend on their differentiation state [0.03%]
人神经干细胞分化状态决定人类巨细胞病毒感染的影响
H M González-Sánchez,A Monsiváis-Urenda,C A Salazar-Aldrete et al.
H M González-Sánchez et al.
Cytomegalovirus (CMV) is the most common cause of congenital infection in developed countries and a major cause of neurological disability in children. Although CMV can affect multiple organs, the most important sequelae of intrauterine inf...