Progressive multifocal leukoencephalopathy in a young adult with DOCK8 deficiency: a case of JC virus reactivation in primary immunodeficiency [0.03%]
DOCK8缺陷原发性免疫缺陷患者进展性多灶性白质脑病1例：JC病毒再激活所致
Laura Naydovich,Joseph R Berger,Pavle S Milutinovic
Laura Naydovich
Progressive multifocal leukoencephalopathy (PML) is a rare, often fatal demyelinating disease of the central nervous system (CNS) caused by JC virus (JCV) reactivation in the setting of impaired cellular immunity. While commonly associated ...
Clinical features of varicella-zoster virus meningitis diagnosed by polymerase chain reaction without abnormal routine cerebrospinal fluid analysis [0.03%]
脑脊液PCR诊断单纯性水痘带状疱疹病毒性脑膜炎的临床特征及脑脊液常规生化改变分析
Akihiro Kitamura,Ryutaro Nakamura,Seiji Sugiyama et al.
Akihiro Kitamura et al.
This study aimed to investigate the clinical features of varicella-zoster virus (VZV) meningitis cases diagnosed by polymerase chain reaction (PCR) despite normal routine cerebrospinal fluid (CSF) testing. A retrospective review was perform...
LncRNA MCF2L-AS1 inhibits neuronal damage induced by 1-methyl-4-phenylpyridinium (MPP+) via regulating miR-28-5p [0.03%]
长链非编码RNA MCF2L-AS1通过调控miR-28-5p抑制1-甲基-4-苯基吡啶离子诱导的神经元损伤
Dong Chen,Xiaona Dai,Cong Luo
Dong Chen
Parkinson's disease (PD) is the second most prevalent progressive neurological movement condition worldwide. Previous studies have reported aberrant expression of lncRNA MCF2L-AS1 in PD. Therefore, this study aims to investigate the clinica...
Combination antiretroviral therapy prevents SIV-induced aging in the hippocampus and neurodegeneration throughout the brain [0.03%]
联合抗逆转录病毒治疗可防止SIV诱导的海马衰老和全脑神经退行性病变
Miranda D Horn,Alison R Van Zandt,Cecily C Midkiff et al.
Miranda D Horn et al.
Virus-induced accelerated aging has been proposed as a potential mechanism underlying the persistence of HIV-associated brain injury (HABI) despite advances in access and adherence to combination antiretroviral therapies (cART). While some ...
Comparison of clinical, radiological and outcome parameters in patients with progressive multifocal leukoencephalopathy (PML) with and without HIV infection: a cohort study [0.03%]
HIV阳性和阴性患者的进行性多灶性白质脑病(PML)临床、影像和预后特征的队列研究比较
Farsana Mustafa,Anuj Ajayababu,Ajay Garg et al.
Farsana Mustafa et al.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder of the central nervous system (CNS) caused by reactivation of the John Cunningham (JC) polyomavirus, commonly occurring in immunosuppressed individuals. Comparativ...
SARS-CoV-2-induced damage to rat cortical neuronal networks ex vivo is mediated by the pro-inflammatory activation of the cGAS-STING pathway [0.03%]
SARS-CoV-2通过激活cGAS-STING途径的促炎作用对皮质神经元网络造成损伤
Pamela Martinez-Orellana,Matteo Manzati,Diletta Pozzi et al.
Pamela Martinez-Orellana et al.
Severe Acute Respiratory Syndrome Coronavirus-2 infection has been associated to neurological symptoms characteristic of long-lasting post-acute coronavirus disease. However, the complex mechanisms involved in these clinical manifestations ...
Rapid decline of cerebrospinal fluid biomarkers of axonal injury and neuroinflammation after initiation of antiretroviral therapy in HIV [0.03%]
启动抗逆转录病毒治疗后HIV患者的脑脊液轴突损伤和神经炎症生物标志物迅速下降
Linn Renborg,Aylin Yilmaz,Staffan Nilsson et al.
Linn Renborg et al.
Persistent intrathecal immune activation and neuronal injury remain common in people with HIV (PWH) despite effective antiretroviral therapy (ART). We examined longitudinal trajectories of cerebrospinal fluid (CSF) neurofilament light (NfL)...
Regulation of eco-tropic human immunodeficiency virus type-1-infection by sterile alpha motif and histidine-aspartic domain containing protein-1 in a microglial cell line: a novel in vitro model for studying HIV infection and latency in microglia [0.03%]
泛素样作用 modifier激活的人免疫缺陷病毒1型感染的神经元和胶质细胞模型及机制研究
Brita Ostermeier,Clarissa Halpern,Sanjay B Maggirwar
Brita Ostermeier
Microglia are considered the main human immunodeficiency virus (HIV) reservoirs in the central nervous system (CNS) due to their ability to become productively infected, produce new infectious HIV virions, and support HIV latency. The anato...
The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities [0.03%]
ACE2在病毒感染和神经退行性病变中的双重作用：机制及治疗机会
Melika Amelimojarad,Mandana Amelimojarad
Melika Amelimojarad
Angiotensin-converting enzyme 2 (ACE2), a key regulator of the renin-angiotensin system (RAS), maintains central nervous system (CNS) homeostasis by metabolizing neuroinflammatory peptides like angiotensin II (Ang II) and apelin-13, thereby...
The protective role of dexmedetomidine against anaesthetics-induced neurotoxicity through downregulating miR-34a [0.03%]
右美托咪啶通过下调miR-34a对抗麻醉剂引起的神经毒性保护作用研究
Ninghao Chen,Bo Wang,Zhenbin Zhan et al.
Ninghao Chen et al.