The brain's Geppetto-microbes as puppeteers of neural function and behaviour? [0.03%]
大脑的杰佩托-微生物作为神经功能和行为的幕后操纵者？
Roman M Stilling,Timothy G Dinan,John F Cryan
Roman M Stilling
Research on the microbiome and its interaction with various host organs, including the brain, is increasingly gaining momentum. With more evidence establishing a comprehensive microbiota-gut-brain axis, questions have been raised as to the ...
Chronic SIV and morphine treatment increases heat shock protein 5 expression at the synapse [0.03%]
慢性SIV和吗啡治疗增加突触中热休克蛋白5的表达
Gurudutt Pendyala,Palsamy Periyasamy,Shannon Callen et al.
Gurudutt Pendyala et al.
The abuse of opiates such as morphine in synergy with HIV infection accelerates neurocognitive impairments and neuropathology in the CNS of HIV-infected subjects, collectively referred to as HAND. To identify potential pathogenic markers as...
Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV [0.03%]
托卡朋通过抑制儿茶酚-O-甲基转移酶(COMT)恢复神经性HIV对神经细胞中微管相关蛋白2 (MAP2)和突触素(SYP)的降低作用
Ting Ting Lee,Gursharan Chana,Paul R Gorry et al.
Ting Ting Lee et al.
This investigation aimed to assess whether inhibition of cathecol-O-methyl transferase (COMT) by tolcapone could provide neuroprotection against HIV-associated neurodegenerative effects. This study was conducted based on a previous work, wh...
Acute disseminated encephalomyelitis: current knowledge and open questions [0.03%]
急性播散性脑脊髓炎：当前的认识和未解决的问题
Israel Steiner,Peter G E Kennedy
Israel Steiner
Acute disseminated encephalomyelitis (ADEM) is usually an acute, multi-focal, and monophasic immune-mediated disease of the central nervous system. The disorder is mainly a condition of the pediatric age group, but neurologists are also inv...
NTPDase and 5'-nucleotidase activities in synaptosomes of rabbits experimentally infected with BoHV-5 [0.03%]
实验性BoHV-5感染兔子突触体中的NTPDase和5'-核苷酸酶活性研究
Cássia B da Silva,Francine C Paim,Patricia Wolkmer et al.
Cássia B da Silva et al.
Bovine herpesvirus type 5 (BoHV-5) is the causative agent of herpetic meningoencephalitis in cattle. The purinergic system is described as a modulator of the immune response and neuroinflammation. These functions are related to the extracel...
Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues [0.03%]
长期接触核苷类似物的小鼠皮质神经元中线粒体DNA D环AG / TC颠换突变
Yulin Zhang,Bishi Wang,Qi Liang et al.
Yulin Zhang et al.
With the wide application of combined antiretroviral therapy, the prognosis of human immunodeficiency virus (HIV)-1 infected patient has been significantly improved. However, long-term administration of antiretroviral drugs can result in va...
Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy [0.03%]
远端腿皮肤神经纤维密度作为HIV感觉神经病风险的替代标志物：危险因素及初始抗逆转录病毒治疗后的改变
Cecilia M Shikuma,Kara Bennett,Jintanat Ananworanich et al.
Cecilia M Shikuma et al.
Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how i...
Randomized Controlled Trial
Journal of neurovirology. 2015 Oct;21(5):525-34. DOI:10.1007/s13365-015-0352-0 2015
Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation [0.03%]
使用活体小鼠UV-B诱发激活模型分析一种单纯疱疹病毒1型(HSV-1)潜伏相关转录本(LAT)突变体的再激活减少现象
Lbachir BenMohamed,Nelson Osorio,Ruchi Srivastava et al.
Lbachir BenMohamed et al.
Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular immune mechanisms that control the HSV-1 latency-reactiv...
Alan C Jackson
Alan C Jackson
Rabies is an acute encephalomyelitis in humans and animals caused by rabies virus (RABV) infection. Because the neuropathological changes are very mild in rabies, it has been assumed that neuronal dysfunction likely explains the severe clin...
Reverse genetics of rabies virus: new strategies to attenuate virus virulence for vaccine development [0.03%]
狂犬病毒的反向遗传学：为疫苗开发减弱病毒毒力的新策略
Shimao Zhu,Hui Li,Chunhua Wang et al.
Shimao Zhu et al.
Rabies is an ancient neurological disease that is almost invariably fatal once the clinical symptoms develop. Currently, prompt wound cleansing after exposing to a potentially rabid animal and vaccination using rabies vaccine combined with ...