Stroke in HIV-infected African Americans: a retrospective cohort study [0.03%]
非洲裔美国人中艾滋病病毒感染者发生卒中的病例对照研究
Kiran T Thakur,Jennifer L Lyons,Bryan R Smith et al.
Kiran T Thakur et al.
The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of Afri...
David P Sheppard,Jennifer E Iudicello,Mark W Bondi et al.
David P Sheppard et al.
With the rising number of individuals in their 50s and 60s who are infected with HIV, concerns have emerged about possible increases in the rates of non-HIV-associated dementias. The current study examined the prevalence of mild cognitive i...
Mind-altering microbes [0.03%]
改变思维的微生物
Alan C Jackson
Alan C Jackson
HSV encephalitis-induced anti-NMDAR encephalitis in a 67-year-old woman: report of a case and review of the literature [0.03%]
1例67岁女性巨细胞病毒性脑炎后伴发N-甲基-D-天冬氨酸受体脑炎的临床报道及文献复习
Nicholas A Morris,Tamara B Kaplan,Jenny Linnoila et al.
Nicholas A Morris et al.
Herpes simplex virus (HSV) encephalitis can induce an autoimmune encephalitis mediated by autoantibodies against the N-methyl-D-aspartate receptor (NMDAR). Post-HSV NMDAR encephalitis and de novo NMDAR encephalitis have been more commonly d...
Spinal cord progressive multifocal leukoencephalopathy detected premortem by MRI [0.03%]
术前经磁共振检查发现脊髓进行性多灶性白质脑病
Roger Murayi,James Schmitt,John H Woo et al.
Roger Murayi et al.
HIV-infected microglia mediate cathepsin B-induced neurotoxicity [0.03%]
感染HIV的小胶质细胞介导了半胱天冬酶B诱导的神经毒性反应
Frances Zenón,Yisel Cantres-Rosario,Radhika Adiga et al.
Frances Zenón et al.
HIV-1-infected mononuclear phagocytes release soluble factors that affect the homeostasis in tissue. HIV-1 can prompt metabolic encephalopathy with the addition of neuronal dysfunction and apoptosis. Recently, we reported that HIV-1 enhance...
Peripheral aetiopathogenic drivers and mediators of Parkinson's disease and co-morbidities: role of gastrointestinal microbiota [0.03%]
肠道微生物群在帕金森病及其共患病的周边致病因素和介质中的作用
Sylvia M Dobbs,R John Dobbs,Clive Weller et al.
Sylvia M Dobbs et al.
We seek an aetiopathogenic model for the spectrum of Parkinson's disease (PD), functional bowel disease, depression and cognitive impairment. The adopted concept is that systemic immuno-inflammatory processes mediate neuro-inflammation. The...
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT) [0.03%]
单纯疱疹病毒1型(HSV-1)潜伏相关转录本(LAT)通过维持蛋白激酶B(AKT)的磷酸化来保护细胞免受冷休克诱导的凋亡损伤
Dale Carpenter,Chinhui Hsiang,Xianzhi Jiang et al.
Dale Carpenter et al.
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) blocks apoptosis and inhibits caspase-3 activation. We previously showed that serum starvation (removal of serum from tissue culture media), which takes several day...
Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2 [0.03%]
缺少LAT miR-H2的单纯疱疹病毒dLAT2903突变体的神经毒力和潜伏再激活增加
Xianzhi Jiang,Don Brown,Nelson Osorio et al.
Xianzhi Jiang et al.
At least six microRNAs (miRNAs) appear to be encoded by the latency-associated transcript (LAT) of herpes simplex virus type 1 (HSV-1). The gene for ICP0, an important immediate early (IE) viral protein, is anti-sense to, and overlaps with,...
CSF biomarkers of monocyte activation and chemotaxis correlate with magnetic resonance spectroscopy metabolites during chronic HIV disease [0.03%]
慢性HIV疾病期间单核细胞激活和趋化性生物标志物与磁共振波谱代谢产物的相关性研究
Albert M Anderson,Christine Fennema-Notestine,Anya Umlauf et al.
Albert M Anderson et al.
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART), supporting the need to better understand HIV neuropathogenesis. Magnetic resonance spectroscopy (MRS) o...
Observational Study
Journal of neurovirology. 2015 Oct;21(5):559-67. DOI:10.1007/s13365-015-0359-6 2015