Peripheral neuropathy in HIV patients in sub-Saharan Africa failing first-line therapy and the response to second-line ART in the EARNEST trial [0.03%]
东非和南部非洲EARNEST试验中一线抗逆转录病毒治疗失败的患者出现外周神经病变及其二线治疗反应
Alejandro Arenas-Pinto,Jennifer Thompson,Godfrey Musoro et al.
Alejandro Arenas-Pinto et al.
Sensory peripheral neuropathy (PN) remains a common complication in HIV-positive patients despite effective combination anti-retroviral therapy (ART). Data on PN on second-line ART is scarce. We assessed PN using a standard tool in patients...
Randomized Controlled Trial
Journal of neurovirology. 2016 Feb;22(1):104-13. DOI:10.1007/s13365-015-0374-7 2016
Subtype associations with HIV-associated neurocognitive disorder in China [0.03%]
中国与获得性免疫缺陷综合征相关性神经认知障碍亚型的相关性研究
Tyler R C Day,Davey M Smith,Robert K Heaton et al.
Tyler R C Day et al.
Factors associated with HIV-associated neurocognitive disorders (HAND) include CD4(+) nadir and count, HIV RNA level, and HIV-1 subtype. Here, we investigated demographical and clinical markers with respect to HAND in a homogenous Chinese p...
Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain [0.03%]
尼古丁调节HIV-1转基因大鼠脑组织抗氧化相关基因的表达
Guohua Song,Tanseli Nesil,Junran Cao et al.
Guohua Song et al.
Oxidative stress plays an important role in the progression of HIV-1 infection. Nicotine can either protect neurons from neurodegeneration or induce oxidative stress, depending on its dose and degree of oxidative stress impairment. However,...
Human immunodeficiency virus has similar effects on brain volumetrics and cognition in males and females [0.03%]
人类免疫缺陷病毒对男性和女性大脑体积和认知的影响类似
Ashley M Behrman-Lay,Robert H Paul,Jodi Heaps-Woodruff et al.
Ashley M Behrman-Lay et al.
Most studies that have examined neuropsychological impairments associated with human immunodeficiency virus (HIV) have focused on males, yet females represent one of the largest groups of newly infected patients. Further, few studies have e...
Anna M Bank,Ayush Batra,Rene A Colorado et al.
Anna M Bank et al.
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that is endemic to parts of Africa, South and Southeast Asia, and more recently the Caribbean. Patients typically present with fever, rash, and arthralgias, though neurologic symptoms...
The role of depression chronicity and recurrence on neurocognitive dysfunctions in HIV-infected adults [0.03%]
抑郁症的持续性和反复发作对HIV感染者神经认知功能的影响
Lucette A Cysique,Nadene Dermody,Andrew Carr et al.
Lucette A Cysique et al.
Research assessing whether major depressive disorders (MDD) impacts neurocognitive functions in HIV+ persons has yielded inconsistent results. However, none have considered the role of MDD remission, chronicity, and stability on treatment. ...
Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60 [0.03%]
人类免疫缺陷病毒感染者大于60岁人群的固有网络连接异常现象
Anika Guha,Liang Wang,Aaron Tanenbaum et al.
Anika Guha et al.
Individuals infected with HIV are living longer due to effective treatment with combination antiretroviral therapy (cART). Despite these advances, HIV-associated neurocognitive disorders (HAND) remain prevalent. In this study, we analyzed r...
The immune response in the CNS in Theiler's virus induced demyelinating disease switches from an early adaptive response to a chronic innate-like response [0.03%]
陶氏病毒引起的中枢神经系统免疫反应由最初的适应性免疫应答转为慢性先天性免疫样应答
Francesca Gilli,Libin Li,Andrew R Pachner
Francesca Gilli
Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is an important model of the progressive disability caused by irreversible CNS tissue injury, and provides an example of how a CNS pathogen can cause inflamma...
Blood brain barrier impairment is associated with cerebrospinal fluid markers of neuronal damage in HIV-positive patients [0.03%]
HIV患者血脑屏障损害与神经元损伤脑脊液标志物相关性研究
A Calcagno,C Atzori,A Romito et al.
A Calcagno et al.
Blood brain barrier impairment occurs early in the course of infection by HIV and it may persist in a subset of patients despite effective antiretroviral treatment. We tested the hypothesis that HIV-positive patients with dysfunctional bloo...
Progressive multifocal leukoencephalopathy mimicking milliary CNS tuberculosis [0.03%]
类渐进多灶性白质脑病伴有粟粒样改变的进行性多灶性白质脑病一例报告
Iñigo Corral,Carmen Quereda,Fernando Dronda et al.
Iñigo Corral et al.