Salman Naeem,Asma Shabbir,Abdus Salam Khan et al.
Salman Naeem et al.
Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV [0.03%]
HIV神经认知障碍的神经病理发生学的多水平分析
Andrew J Levine,Virawudh Soontornniyomkij,Cristian L Achim et al.
Andrew J Levine et al.
The neuropathogenesis of HIV-associated neurocognitive disorders (HAND) remains puzzling. We interrogated several levels of data (host genetic, histopathology, brain viral load, and neurocognitive) to identify histopathological changes most...
HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors [0.03%]
人类T细胞白血病病毒Ⅰ型亚群与HAM/TSP风险相关，且与外周血单个核细胞中病毒和宿主基因表达有关，独立于病毒转录活化功能的影响
Keiko Yasuma,Toshio Matsuzaki,Yoshihisa Yamano et al.
Keiko Yasuma et al.
Among human T cell leukemia virus type 1 (HTLV-1)-infected individuals, the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) across lifetime differs between ethnic groups. There is an association betwee...
Depletion of Olig2 in oligodendrocyte progenitor cells infected by Theiler's murine encephalomyelitis virus [0.03%]
Theiler病毒感染的少突胶质前体细胞中Olig2耗竭
Bayleigh Benner,Anthony J Martorell,Padmanabhan Mahadevan et al.
Bayleigh Benner et al.
Theiler's murine encephalomyelitis virus (TMEV) infects the central nervous system of mice and causes a demyelinating disease that is a model for multiple sclerosis. During the chronic phase of the disease, TMEV persists in oligodendrocytes...
Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides [0.03%]
纳米医学递送的Nef肽可治疗小胶质细胞衍生的HIV Nef阳性外泌体对血脑屏障的损害
A D Raymond,P Diaz,S Chevelon et al.
A D Raymond et al.
The negative factor (Nef) of human immunodeficiency virus (HIV) is an accessory protein that is thought to be integral to HIV-associated immune- and neuroimmune pathogenesis. Here, we show that nef-transfected microglia-released Nef+ exosom...
Mudit Tyagi,Jaime Weber,Michael Bukrinsky et al.
Mudit Tyagi et al.
Illicit drug users are a high-risk population for infection with the human immunodeficiency virus (HIV). A strong correlation exists between prohibited drug use and an increased rate of HIV transmission. Cocaine stands out as one of the mos...
Central nervous system penetration effectiveness of antiretroviral drugs and neuropsychological impairment in the Ontario HIV Treatment Network Cohort Study [0.03%]
抗逆转录病毒药物进入中枢神经系统的有效性以及在安大略艾滋病治疗网络队列研究中对神经心理学功能的影响
Adriana Carvalhal,M John Gill,Scott L Letendre et al.
Adriana Carvalhal et al.
Since the introduction of combination antiretroviral therapy (cART), the incidence of severe HIV-associated neurocognitive impairment has declined significantly, whereas the prevalence of the milder forms has increased. Studies suggest that...
Susanna L Lamers,Rebecca Rose,Lishomwa C Ndhlovu et al.
Susanna L Lamers et al.
Two innovative studies recently identified functional lymphatic structures in the meninges that may influence the development of HIV-associated neurological disorders (HAND). Until now, blood vessels were assumed to be the sole transport sy...
Overexpression of caspase 1 in apoptosis-resistant astrocytes infected with the BeAn Theiler's virus [0.03%]
贝安Theiler病毒感染的抗凋亡星形胶质细胞中caspase 1过度表达
Nazario Rubio,Francisco Sanz-Rodriguez
Nazario Rubio
In this study, we demonstrate the upregulation in the expression of caspases 1 and 11 by SJL/J mouse brain astrocytes infected with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV). The upregulation of both proteases hints...
Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder [0.03%]
HIV感染患者神经细胞和死后脑中CHRFAM7A和CHRNA7的表达：与获得性免疫缺陷综合征相关性神经认知障碍的考虑因素
Félix M Ramos,Manuel Delgado-Vélez,Ángel L Ortiz et al.
Félix M Ramos et al.
Despite the recent advances in antiretroviral therapy, human immunodeficiency virus type 1 (HIV-1) remains a global health threat. HIV-1 affects the central nervous system by releasing viral proteins that trigger neuronal death and neuroinf...