Avindra Nath
Avindra Nath
Persistent CSF but not plasma HIV RNA is associated with increased risk of new-onset moderate-to-severe depressive symptoms; a prospective cohort study [0.03%]
一项前瞻性队列研究：持续的脑脊液HIV RNA（而非血浆）与中重度抑郁症状发病风险增加相关
Edward R Hammond,Rosa M Crum,Glenn J Treisman et al.
Edward R Hammond et al.
Major depressive disorder is the most common neuropsychiatric complication in human immunodeficiency virus (HIV) infections and is associated with worse clinical outcomes. We determined if detectable cerebrospinal fluid (CSF) HIV ribonuclei...
Detection frequency of human herpesviruses-6A, -6B, and -7 genomic sequences in central nervous system DNA samples from post-mortem individuals with unspecified encephalopathy [0.03%]
检测人类疱疹病毒6A、6B和7的基因序列在不明原因脑病患者死后中枢神经系统DNA样品中的频率
Svetlana Chapenko,Silvija Roga,Sandra Skuja et al.
Svetlana Chapenko et al.
In this autopsy-based study, human herpesvirus-6 (HHV-6) and -7 (HHV-7) genomic sequence frequency, HHV-6 variants, HHV-6 load and the expression of HHV-6 antigens in brain samples from the individuals, with and without unspecified encephal...
Enterovirus causes rapidly progressive dementia in a 28-year-old immunosuppressed woman [0.03%]
免疫抑制女性肠道病毒导致快速进展性痴呆病例报告
Sneha Mantri,Binit B Shah
Sneha Mantri
Enterovirus in the nervous system can present with protean manifestations, including polio-like paralysis, movement disorders, and seizures. This is a report of a single case of a rapidly progressive dementing illness in a young woman with ...
Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells [0.03%]
HIV-1潜伏逆转剂对中枢神经系统的毒性及体外活性
Lachlan R Gray,Hung On,Emma Roberts et al.
Lachlan R Gray et al.
Despite the success of combination antiretroviral therapy (cART), HIV persists in long lived latently infected cells in the blood and tissue, and treatment is required lifelong. Recent clinical studies have trialed latency-reversing agents ...
The impact of human immune deficiency virus and hepatitis C coinfection on white matter microstructural integrity [0.03%]
人类免疫缺陷病毒和丙型肝炎病毒感染对白质微观结构的影响
J M Heaps-Woodruff,P W Wright,B M Ances et al.
J M Heaps-Woodruff et al.
The purpose of the present study is to examine the integrity of white matter microstructure among individuals coinfected with HIV and HCV using diffusion tensor imaging (DTI). Twenty-five HIV+ patients, 21 HIV+/HCV+ patients, and 25 HIV- co...
Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders [0.03%]
与HIV相关的神经认知障碍有关的大脑表观遗传老化加速
Andrew J Levine,Austin Quach,David J Moore et al.
Andrew J Levine et al.
HIV infection leads to age-related conditions in relatively young persons. HIV-associated neurocognitive disorders (HAND) are considered among the most prevalent of these conditions. To study the mechanisms underlying this disorder, researc...
The impact of ethnicity/race on the association between the Veterans Aging Cohort Study (VACS) Index and neurocognitive function among HIV-infected persons [0.03%]
种族对艾滋病病毒感染者Veterans Aging Cohort Study(VACS)指数和神经认知功能之间的影响关系的研究
M J Marquine,M Sakamoto,C Dufour et al.
M J Marquine et al.
The Veterans Aging Cohort Study (VACS) Index was developed as a risk index for health outcomes in HIV, and it has been consistently associated with mortality. It shows a significant, yet relatively weak, association with neurocognitive impa...
Predictors and characteristics of seizures in survivors of progressive multifocal leukoencephalopathy [0.03%]
进行性多灶性白质脑病幸存者癫痫的预后和特征分析
Dhanashri P Miskin,Susan T Herman,Long H Ngo et al.
Dhanashri P Miskin et al.
This study aims to determine the risk factors for epileptogenesis and characteristics of seizures in patients with progressive multifocal leukoencephalopathy (PML) who survive more than 1 year from onset of neurological symptoms (PML surviv...
Characterization of the immune response in ganglia after primary simian varicella virus infection [0.03%]
原猴带状疱疹病毒初次感染后的神经节免疫反应特征分析
Werner J D Ouwendijk,Sarah Getu,Ravi Mahalingam et al.
Werner J D Ouwendijk et al.
Primary simian varicella virus (SVV) infection in non-human primates causes varicella, after which the virus becomes latent in ganglionic neurons and reactivates to cause zoster. The host response in ganglia during establishment of latency ...