Mapping ACE2 and TMPRSS2 co-expression in human brain tissue: implications for SARS-CoV-2 neurological manifestations [0.03%]
人脑组织中ACE2和TMPRSS2的共表达映射：对SARS-CoV-2神经系统表现的影响
Tulika Gupta,Munish Kumar,Ujjwal Jit Kaur et al.
Tulika Gupta et al.
The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets respiratory cells, but emerging evidence shows neurological involvement, with the virus directly affecting neu...
Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid cultures [0.03%]
人多能干细胞来源脑类器官的HIV感染及神经炎症研究模型
Martina Donadoni,Senem Cakir,Anna Bellizzi et al.
Martina Donadoni et al.
The human immunodeficiency virus (HIV) epidemic is an ongoing global health problem affecting 38 million people worldwide with nearly 1.6 million new infections every year. Despite the advent of combined antiretroviral therapy (cART), a lar...
Differences in neuroinflammation in people who started antiretroviral treatment during primary versus chronic HIV infection: an 18kDa Translocator protein (TSPO) positron emission tomography (PET) study [0.03%]
人类在急性期与慢性期开始抗逆转录病毒治疗后的神经炎症差异：一种正电子发射断层扫描研究
Jasmini Alagaratnam,John P Thornhill,Zhen Fan et al.
Jasmini Alagaratnam et al.
Persistent inflammation is described in people with HIV (PWH) on antiretroviral treatment (ART). Early ART initiation is associated with reduced inflammation. We aimed to evaluate neuroinflammation, using translocator protein (TSPO) [11C]PB...
Clinical characteristics and outcomes of COVID-19-associated encephalopathy in children [0.03%]
儿童COVID-19相关性脑病的临床特征及转归分析
Li Li,Hongmei Liao,Xiaojun Kuang et al.
Li Li et al.
Apart from the typical respiratory symptoms, coronavirus disease 2019 (COVID-19) also affects the central nervous system, leading to central disorders such as encephalopathy and encephalitis. However, knowledge of pediatric COVID-19-associa...
Implications of vascular depression for successful cognitive aging in HIV Disease [0.03%]
血管性抑郁对艾滋病患者成功认知老化的意义
Andrea I Mustafa,Ilex Beltran-Najera,Darrian Evans et al.
Andrea I Mustafa et al.
Although older adults with HIV are at high risk for mild neurocognitive disorders, a subset experience successful cognitive aging (SCA). HIV is associated with an increased risk of vascular depression (VasDep), which can affect cognitive an...
Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging [0.03%]
系统性红斑狼疮相关进行性多灶性白质脑病的纵向观察：脑脊液淋巴细胞、JC病毒和磁共振成像的长期变化规律
Hidetada Yamada,Megumi Toko,Masahiro Nakamori et al.
Hidetada Yamada et al.
Progressive multifocal leukoencephalopathy (PML) rarely occurs in patients with systemic lupus erythematosus (SLE). This report presents the case of a patient who developed PML due to SLE-associated multiple factors. A 60-year-old woman dia...
RNA-Seq time-course analysis of neural precursor cell transcriptome in response to herpes simplex Virus-1 infection [0.03%]
HSV-1感染后神经前体细胞转录组的RNA-Seq时间过程分析
Joel A Wood,Srilakshmi Chaparala,Cecilia Bantang et al.
Joel A Wood et al.
The neurogenic niches within the central nervous system serve as essential reservoirs for neural precursor cells (NPCs), playing a crucial role in neurogenesis. However, these NPCs are particularly vulnerable to infection by the herpes simp...
Cerebrospinal Fluid Biomarkers of Symptomatic Neurosyphilis in People With HIV Compared with Uninfected Individuals [0.03%]
HIV感染者与未感染者的神经梅毒的脑脊液生物标志物比较研究
Sérgio Monteiro de Almeida,José Tresoldi Neto,Amanda Rocha et al.
Sérgio Monteiro de Almeida et al.
We evaluated the diagnostic clinical performance characteristics (DCPC) of cerebrospinal fluid (CSF) total protein (TP), white blood cell count (WBC), and lactate (LA) with different cutoff points as adjunct biomarkers of confirmed or presu...
Tryptophan-kynurenine metabolic pathway and daytime dysfunction in women with HIV [0.03%]
色氨酸-犬尿氨酸代谢途径与HIV女性患者日间功能障碍的关系
Eran Frank Shorer,Leah H Rubin,Audrey L French et al.
Eran Frank Shorer et al.
Sleep disturbances are prevalent in women with HIV (WWH). Tryptophan-kynurenine (T-K) pathway metabolites are associated with alterations in actigraphy derived sleep measures in WWH, although may not always correlate with functional impairm...
Simian varicella virus infection and reactivation in rhesus macaques trigger cytokine and Aβ40/42 alterations in serum and cerebrospinal fluid [0.03%]
猴水痘病毒感染和猕猴体内病毒再活化导致血清和脑脊液中的细胞因子以及Aβ40/42发生改变
Christy S Niemeyer,Vicki Traina-Dorge,Lara Doyle-Meyers et al.
Christy S Niemeyer et al.
Simian varicella virus (SVV) produces peripheral inflammatory responses during varicella (primary infection) and zoster (reactivation) in rhesus macaques (RM). However, it is unclear if peripheral measures are accurate proxies for central n...