Human immunodeficiency virus (HIV) modulates the associations between insulin resistance and cognition in the current combination antiretroviral therapy (cART) era: a study of the Women's Interagency HIV Study (WIHS) [0.03%]
人类免疫缺陷病毒(HIV)调节了当前联合抗逆转录病毒疗法(cART)时代胰岛素抵抗与认知之间的关系：女性间艾滋病队列研究(WIHS)中的一个研究项目
Victor Valcour,Leah H Rubin,Phyllis Tien et al.
Victor Valcour et al.
Cognitive impairment (CI) remains common despite access to combination antiretroviral therapy (cART); it has been linked to HIV-specific, HIV-related, and HIV-unrelated factors. Insulin resistance (IR) was associated with CI in the early cA...
Ivan Jelcic,Ilijas Jelcic,Wolfgang Faigle et al.
Ivan Jelcic et al.
The high prevalence of asymptomatic JC polyomavirus (JCV) infection in the general population indicates coexistence with the human host and efficient immune control in healthy individuals. For unknown reasons, kidney-resident archetypic JCV...
Kamel Khalili,Rafal Kaminski,Jennifer Gordon et al.
Kamel Khalili et al.
Current therapy for controlling human immunodeficiency virus (HIV-1) infection and preventing acquired immunodeficiency syndrome (AIDS) progression has profoundly decreased viral replication in cells susceptible to HIV-1 infection, but it d...
Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress [0.03%]
狂犬病病毒磷蛋白与线粒体复合物I相互作用并诱导线粒体功能障碍和氧化应激
Wafa Kammouni,Heidi Wood,Ali Saleh et al.
Wafa Kammouni et al.
Our previous studies in an experimental model of rabies showed neuronal process degeneration in association with severe clinical disease. Cultured adult rodent dorsal root ganglion neurons infected with challenge virus standard (CVS)-11 str...
Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen [0.03%]
初治患者启动新型抗逆转录病毒治疗后外周神经病变模式分析
Anthony J Lee,Ronald J Bosch,Scott R Evans et al.
Anthony J Lee et al.
The purpose of this study was to evaluate associations of pre-ART CD4 with peripheral neuropathy (PN) and estimate the prevalence of PN in HIV-positive patients starting modern combination antiretroviral therapy (cART) regimens. ART-naïve ...
Randomized Controlled Trial
Journal of neurovirology. 2015 Apr;21(2):210-8. DOI:10.1007/s13365-015-0327-1 2015
Detection of JCPyV microRNA in blood and urine samples of multiple sclerosis patients under natalizumab therapy [0.03%]
纳他珠单抗治疗多发性硬化症患者血液和尿液中JCPyV微小RNAs的检测
Irene Giovannelli,Francesco Martelli,Anna Repice et al.
Irene Giovannelli et al.
Polyomavirus JC (JCPyV) reactivation and development of progressive multifocal leukoencephalopathy is a health concern in multiple sclerosis patients under natalizumab therapy. Here, the JCPyV microRNA-J1-3p and microRNA-J1-5p expressions a...
Validity of the Montreal Cognitive Assessment and the HIV Dementia Scale in the assessment of cognitive impairment in HIV-1 infected patients [0.03%]
评估艾滋病病毒感染者认知障碍时蒙特利尔认知评估量表和人类免疫缺陷病毒痴呆量表的有效性
M A M Janssen,M Bosch,P P Koopmans et al.
M A M Janssen et al.
The gold standard for evaluating cognitive impairments in HIV-infected patients is to administer an extensive neuropsychological assessment. This may, however, be time-consuming and hence not always feasible in the clinic. Therefore, severa...
Role of Bruton's tyrosine kinase inhibitors in HIV-1-infected cells [0.03%]
布鲁顿酪氨酸激酶抑制剂在HIV-1感染细胞中的作用
Irene Guendel,Sergey Iordanskiy,Gavin C Sampey et al.
Irene Guendel et al.
Many cellular cofactors have been documented to be critical for various stages of viral replication. Using high-throughput proteomic assays, we have previously identified Bruton's tyrosine kinase (BTK) as a host protein that was uniquely up...
Early nucleosome deposition on, and replication of, HSV DNA requires cell factor PCNA [0.03%]
疱疹病毒DNA早期核小体沉积和复制需要细胞因子PCNA
Iryna Sanders,Mark Boyer,Nigel W Fraser
Iryna Sanders
Herpes simplex virus (HSV) is a double-stranded DNA virus that can cause lytic infections in epithelial cells of the skin and latent infections in neuronal cells of the peripheral nervous system. After virion attachment to the cell membrane...
Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques [0.03%]
恒河猴和猪尾猕猴感染猴免疫缺陷病毒后中枢神经系统疾病的发病率不同
Sarah E Beck,Kathleen M Kelly,Suzanne E Queen et al.
Sarah E Beck et al.
Immune pressure exerted by MHC class I-restricted cytotoxic T cells drives the development of viral escape mutations, thereby regulating HIV disease progression. Nonetheless, the relationship between host immunity and HIV central nervous sy...