PEDF inhibits VEGF-induced vascular leakage through binding to VEGFR2 in acute myocardial infarction [0.03%]
PEDF通过与VEGFR2结合抑制急性心肌梗死中VEGF诱导的血管泄漏
Hong-Liang Hui,Bo Jiang,Yan-Ying Zhou et al.
Hong-Liang Hui et al.
Pigment epithelium-derived factor (PEDF) could bind to vascular endothelial growth factor receptor 2 (VEGFR2) and inhibit its activation induced by VEGF. But how PEDF affects VEGFR2 pathway is still poorly understood. In this study, we eluc...
Spectroscopic insights with molecular docking and molecular dynamic simulation studies of anticancer drug 5-Fluorouracil targeting human pyruvate kinase m2 [0.03%]
光谱研究抗癌症药物5-氟尿嘧啶作用于人丙酮酸激酶m2的分子对接和动力学模拟研究
Mamali Priyadarshinee,Budheswar Dehury,Sarbani Mishra et al.
Mamali Priyadarshinee et al.
This study was conducted to test the efficacy of 5-fluorouracil (5-FU) as an anticancer drug against the human pyruvate kinase isozyme M2 (PKM2) using spectroscopic, molecular docking and molecular dynamic simulation studies. PKM2 fluoresce...
Analysis of SIKVAV's receptor affinity, pharmacokinetics, and pharmacological characteristics: a matrikine with potent biological function [0.03%]
SIKVA受体亲和力、药代动力学和药理特性分析：具有潜在生物功能的基质金属蛋白酶之一
Livia Alves Filgueiras,Francisco das Chagas Pereira de Andrade,Samuel Iwao Horita et al.
Livia Alves Filgueiras et al.
Matrikines are biologically active peptides generated from fragments fragmentation of extracellular matrix components (ECM) that are functionally distinct from the original full-length molecule. The active matricryptic sites can be unmasked...
Integrated computational and experimental evaluation of phenolic constituents of Apricot fruit L. for antiqourum sensing, antibiofilm, antioxidant, and 15-lox inhibitory properties [0.03%]
杏果L中酚类成分的综合计算和实验评估，用于抗群体感应、抗生物膜、抗氧化及15-LOX抑制特性
Hafiz Abdul Rafey,Mohamed El-Shazly,Tooba Khalid et al.
Hafiz Abdul Rafey et al.
The present study investigated the antioxidant profile together with the antibacterial potential of Apricot L. with the aim to find a functional food based anti-infective lead. Additionally the study evaluated the biofilm and QS inhibitory ...
Assessment of iridoids and their similar structures as antineoplastic drugs by in silico approach [0.03%]
基于计算方法评估作为抗癌药物的环烯醚萜及其类似结构
Prabhat Neupane,Jhashanath Adhikari Subin,Rameshwar Adhikari
Prabhat Neupane
Iridoids commonly found in plants as secondary metabolites have been reported to possess significant biological activities such as anticancer, antioxidant, hypoglycemic, antimicrobial etc. The strong interactions of iridoids with cyclic-dep...
Charge cluster occurrence in land plants' mitochondrial proteomes with functional and structural insights [0.03%]
陆生植物线粒体蛋白质组中电荷簇的发生及其功能和结构解析
Imen Ayadi,Syrine Nebli,Riadh Ben Marzoug et al.
Imen Ayadi et al.
The Charge Clusters (CCs) are involved in key functions and are distributed according to the organism, the protein's type, and the charge of amino acids. In the present study, we have explored the occurrence, position, and annotation as a f...
In silico molecular characterization of TGF-β gene family in Bufo bufo: genome-wide analysis [0.03%]
Bufo bufo中TGF-β基因家族的计算机模拟分子特征分析：全基因组分析
Mehwish Sultana,Muhammad Tayyab,Sunil et al.
Mehwish Sultana et al.
Bufo bufo is a living example of evolutionary processes due to its numerous physiological and ecological adaptations. This is the first study to genetically characterize the TGF-β gene family in B. bufo at the genome-wide level, and a tota...
A mini review on human serum albumin - natural alkaloids interaction and its role as drug carrier [0.03%]
人血清白蛋白与天然生物碱的相互作用及其作为药物载体的作用机制简述
Tapas Ghosh,Kakali Bhadra
Tapas Ghosh
Human serum albumin (HSA) is one of the main protein components of the circulatory system. It's well characterized physiological role is to carry numerous ligands to their target site. Overall pharmacokinetic profile of a drug is deliberate...
Whole genome based identification of BAHD acyltransferase gene involved in piperine biosynthetic pathway in black pepper [0.03%]
全基因组揭示黑胡椒中辣椒素生物合成途径的BAHD酰基转移酶基因识别
M A Fayad,Sona Charles,S Shelvy et al.
M A Fayad et al.
Black pepper (Piper nigrum L.), a crop of the genus Piper, is an important spice that has both economic and ecological significance. It is widely regarded as the "King of Spices" because of its pungency, attributed to the presence of piperi...
Synthesis, biological profile and computational insights of new derivatives of benzo [B][1,4] diazepines as prospective anticancer agents for inhibiting the CDK-2 protein [0.03%]
苯并[B][1,4] diazepine新型衍生物的合成，生物谱和计算见解作为抗癌药物来抑制CDK-2蛋白
Parvaiz A Dar,Basharat A Bhat,Mushtaq A Mir et al.
Parvaiz A Dar et al.
In the current work, a new series of benzo[b][1, 4] diazepines (A-1 to C-4) was synthesized and screened against three different human cancer cell lines, HepG2 (hepatocellular carcinoma), HeLa (cervical cancer) and MCF-7 (breast cancer), by...