Mechanistic insights into the HuR-V225I mutation and its impact on PKCδ binding dynamics in adult T-cell leukemia [0.03%]
HuR-V225I突变及其对成人T细胞白血病中PKCδ结合动力学的影响机制研究
Abeer M Al-Subaie,Balu Kamaraj
Abeer M Al-Subaie
HuR (ELAVL1) is a key RNA-binding protein involved in mRNA stability and translation, and its disrupted localization and function are strongly associated with leukemic development. This study investigates the interaction between HuR and the...
Computational design and experimental evaluation of a biotinylated DNA aptamer against Entamoeba histolytica actin [0.03%]
计算设计并实验评估针对溶组织内阿米巴肌动蛋白的生物素化DNA适配体
Syahrul Amin Sa&#x;adon,Nur Nadiah Abdul Rashid,Khairul Mohd Fadzli Mustafa et al.
Syahrul Amin Sa&#x;adon et al.
Amoebiasis, caused by Entamoeba histolytica, remains a global health concern due to its asymptomatic nature and potential for severe complications such as liver abscesses. To investigate molecular recognition mechanisms, this study focused ...
Impact of alanine mutations on buffalo nasal odorant binding protein-ligand interactions: implications for estrus biosensing [0.03%]
丙氨酸突变对水牛鼻气味结合蛋白-配体相互作用的影响：发情生物传感的启示
Govindaraj Senthil Kumar,Durairaj Rajesh,Seshadri Shriinikesan et al.
Govindaraj Senthil Kumar et al.
Buffaloes are economically important livestock; however, their reproductive efficiency remains low due to poor estrus detection, leading to missed opportunities for artificial insemination. Buffaloes release volatile pheromonal cues during ...
Unravelling the conformational dynamics of pathogenic mutations of apolipoprotein M: an integrative computational and molecular dynamics simulation approach [0.03%]
一种整合的计算和分子动力学模拟方法解析载脂蛋白M致病突变体的构象动力学
Rahul Yadav,Krishnan Venkatraman
Rahul Yadav
Apolipoprotein M (ApoM), a sphingosine-1-phosphate (S1P) binding protein, is primarily synthesized in the liver and kidney. It is a key component of high-density lipoprotein (HDL) and plays a pivotal role in reverse cholesterol transport, v...
Baicalin executes anticancer property via inhibition of MDM2-p53 interaction: a mechanistic study using in silico approach [0.03%]
基于分子对接的黄芩素抗肿瘤活性及其作用机制研究
Dharmendra Kumar Maurya,Prashasti Sharma
Dharmendra Kumar Maurya
The tumor suppressor p53 plays a central role in regulating intrinsic apoptosis, and its activity is frequently impaired through overexpression of its negative regulator MDM2. Disrupting the MDM2-p53 interaction is therefore a promising str...
Changes in biophysical characteristics of NAD(P)H dependent YghA from E. coli due to variation in pH [0.03%]
大肠杆菌NAD(P)H依赖型YghA在pH改变下的生物物理特性变化研究
Md Nadir Hassan,S Bilal Jilani,Sana Saeed et al.
Md Nadir Hassan et al.
YghA from E. coli has been reported to be involved in conferring tolerance against furan aldehyde inhibitors which are commonly generated in thermo-acidic pretreatment of lignocellulosic biomass. In this study we report the biophysical char...
DNA sequence perplexity analysis of TATA and no-motif promoters reveal conserved informational architectures in eukaryotic genomes [0.03%]
TATA和无 motifs 启动子的 DNA 序列复杂性分析揭示了真核基因组中的保守信息架构
Aruna Sesha Chandrika Gummadi,Venkata Rajesh Yella
Aruna Sesha Chandrika Gummadi
Promoters are the genetic elements that govern the transcription of all coding and non-coding genes. The TATA box is the most conserved promoter element across genomes, encompassing from single-celled yeasts to complex mammals. Previous stu...
Structural insights into predicted thermophilic GH5 cellulases for industrial lignocellulose bioconversion [0.03%]
极端耐热性GH5型纤维素酶的结构及催化机制研究
Pablo Daniel Farace,Rubén Marrero Diaz de Villegas,María Laura Mon et al.
Pablo Daniel Farace et al.
Lignocellulosic biomass can be converted into biofuels and other valuable bioproducts, but it must first undergo physicochemical and enzymatic degradation. Among the various enzymes involved in lignocellulose degradation, thermophilic glyco...
Mechanistic insights into the interaction of emerging SARS-CoV-2 spike variants with the transferrin receptor [0.03%]
关于新兴冠状病毒SARS-CoV-2刺突蛋白变异体与转铁蛋白受体相互作用的机制研究
Jiajia Wu,Wenlong Li,Peihua Wu et al.
Jiajia Wu et al.
Since the onset of the COVID-19 pandemic, SARS-CoV-2 has posed a substantial threat to global health and safety. While the virus's entry into human cells via the interaction of its spike protein with the angiotensin-converting enzyme 2 (ACE...
Effects of temperature and molecular crowding on the sensitivity of the 8GZL DNA aptamer toward Cd2+: a molecular dynamics study [0.03%]
温度和分子拥挤对DNA适配体8GZL识别Cd²⁺的影响：基于分子动力学模拟的研究
Huxuan Chen,Yanhui Liu,Chen Chen et al.
Huxuan Chen et al.
Aptamers show great promise for the specific detection of heavy metal ions, yet their binding affinity can be significantly influenced by environmental conditions. We investigated how temperature and molecular crowding modulate the sensitiv...