10 years of Severe Acute Respiratory Infections Network (SARInet plus): accomplishments and way forward [0.03%]
我国急性呼吸道感染监测网络(SARinetwork)十年的成就与展望
Marc Rondy,Eduardo Azziz-Baumgartner,Rebecca Kondor et al.
Marc Rondy et al.
From Epidemics to Pandemics: Over a Decade of SARInet Strengthening and Laboratory Surveillance and Response for Respiratory Viruses in the Americas [0.03%]
从流行病到大流行病：SARInet在美洲加强呼吸系统病毒实验室监测和反应十多年的经验教训
Juliana A Leite,Priscila S Born,Angel Rodriguez et al.
Juliana A Leite et al.
Matthew B Laurens
Matthew B Laurens
Clinical trials that employ human challenge, also known as controlled human infection models (CHIM), have rapidly advanced vaccine development for multiple pathogens, including at least 30 disease models to date. CHIM studies, championed by...
Population-level Impact of HPV Vaccination on the Incidence of Genital Warts in Sweden [0.03%]
人乳头瘤病毒疫苗对瑞典生殖器疣发病率的群体影响
Ana Martina Astorga Alsina,Eva Herweijer,Jiayao Lei
Ana Martina Astorga Alsina
Background: Sweden introduced HPV vaccination in 2006, administered through opportunistic, subsidized, catch-up and school-based programs. Notably, genital warts (GW) are the first observable clinical outcome following in...
Bacterial vaginosis is associated with transcriptomic changes but not higher concentrations of cervical leukocytes in a study of women at high risk for HIV acquisition [0.03%]
一项针对高风险获得HIV妇女的研究表明细菌性阴道病与转录组变化相关但与宫颈白细胞浓度较高无关
Michelle C Sabo,Salwa Mustafa,Aparajita Saha et al.
Michelle C Sabo et al.
Background: The association between bacterial vaginosis (BV) and increased HIV acquisition risk may be related to concentrations of HIV-susceptible immune cells in the cervix. ...
Global Impact of Mass Vaccination Campaigns on Circulating Type 2 Vaccine-Derived Poliovirus Outbreaks: An Interrupted Time-Series Analysis [0.03%]
大规模脊髓灰质炎疫苗接种运动对循环II型疫苗衍生脊髓灰质炎病毒的影响：一项中断时间序列分析
Laura V Cooper,Ananda S Bandyopadhyay,Nicholas C Grassly et al.
Laura V Cooper et al.
Background: Between 2016 and 2023, 3248 cases of circulating vaccine-derived type 2 poliomyelitis (cVDPV2) were reported globally and supplementary immunization activities (SIAs) with monovalent type 2 oral poliovirus vac...
Resistance Analyses in Heavily Treatment-Experienced People with HIV Treated with the Novel HIV Capsid Inhibitor Lenacapavir After 2 years [0.03%]
两年来使用新型人类免疫缺陷病毒衣壳抑制剂lenacapavir治疗的高度经验丰富的抗逆转录病毒药物受试者的耐药分析
Nicolas A Margot,Vamshi Jogiraju,Nina Pennetzdorfer et al.
Nicolas A Margot et al.
Background: Lenacapavir is a highly potent first-in-class inhibitor of HIV-1 capsid approved for the treatment of heavily treatment-experienced (HTE) people with HIV-1 (PWH) harboring multidrug resistant (MDR) virus, in c...
Impact of attaining an aggressive PK/PD target with continuous infusion beta-lactams on the clinical efficacy of targeted therapy of early post-transplant Gram-negative infections in critically ill OLT recipients. An interim analysis of a 3-year prospective, observational, study [0.03%]
连续输注β-内酰胺类抗菌药物达到激进的药代动力学/药效学目标对危重肝移植受者早期移植物耐碳青霉烯肠杆菌感染靶向治疗临床疗效的影响：一项为期三年的前瞻性观察研究的中期分析结果
Milo Gatti,Matteo Rinaldi,Cristiana Laici et al.
Milo Gatti et al.
Background: To assess the impact of attaining aggressive beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) targets on clinical efficacy in critical orthotopic liver transplant (OLT) recipients with documented early Gram...
Associations between the gut microbiome, inflammation and cardiovascular profiles in people with HIV [0.03%]
HIV患者肠道微生物组、炎症和心血管状况的关系分析
Rachel MacCann,Junhui Li,Alejandro Abner Garcia Leon et al.
Rachel MacCann et al.
Background: Inflammation and innate immune activation are associated with chronic HIV infection, despite effective treatment. Although gut microbiota alterations are linked to systemic inflammation, the relationships betw...