Mucosal IgG Interacts with Herpes Simplex Virus Glycoprotein E, an Fcγ Receptor Mimetic, and Neutralizes Viral Infection: Activity is Reduced in the Setting of Vaginal Dysbiosis [0.03%]
黏膜IgG与单纯疱疹病毒糖蛋白E(一种Fcγ受体模拟物)相互作用并中和病毒感染：阴道菌群失调时该活性降低
Aakash Mahant Mahant,Valerie Fong,Matthew Gromisch et al.
Aakash Mahant Mahant et al.
Background: Small studies have documented variable neutralizing activity of cervicovaginal lavage (CVL) against herpes simplex viruses (HSV). This neutralizing activity is lower in women with bacterial vaginosis (BV), a s...
Crisis as Catalyst: The future of the NIH driving scientific discovery [0.03%]
危机成机遇：美国国立卫生研究院的科学发现之路
Ana A Weil,Sarah M Baker,Frederick S Buckner et al.
Ana A Weil et al.
Characterization of hepatitis B virus in blood donors who were disqualified based on testing: genotype distribution, infectivity, and replicative fitness in human hepatocytes [0.03%]
基于检测不合格的献血者中的乙型肝炎病毒特征研究：基因型分布、感染性和在人类肝细胞中的复制能力
Rana Eltahan,Bryan J Visser,Santanu Biswas et al.
Rana Eltahan et al.
Objectives: Characterize hepatitis B virus (HBV) isolates from deferred blood donors identified by routine blood screening and confirmatory tests in the US, using virological, serological, and biochemical methods, and eva...
Development of a High-Content Stem Cell Focused Drug Screening Platform for Schistosoma mansoni Using Developmentally Advanced Liver Schistosomula - Functional Insights and New Protein Target Leads [0.03%]
一种用于斯氏血吸虫的高内涵药物筛选平台的发展：以干细胞为重点，使用发育晚期的肝型裂头蚴进行功能研究和新的蛋白质靶标筛选
Sewwandi Perera,Athina Myrto Chioni,Anthony J Walker
Sewwandi Perera
Background: Globally, more than a quarter of a billion people are infected with Schistosoma blood parasites that cause the debilitating disease human schistosomiasis. To assist drug discovery, we developed a novel high co...
Exosomal programmed death ligand 1 in patients with Mycobacterium avium complex lung disease [0.03%]
麻风分枝杆菌复合体肺病患者外泌体程序性死亡配体1
Chi-Yu Hsu,Bo-Shiun Yan,Juo-Hsin Lai et al.
Chi-Yu Hsu et al.
Background: Mycobacterium avium complex lung disease (MAC-LD) is increasing worldwide. Exosomal programmed death-ligand 1 (PD-L1) has been scarcely investigated in MAC-LD. ...
Felippe Lazar,Anna P Durbin
Felippe Lazar
Integrated Methylome and Transcriptome Analysis in Chronic Chagas Cardiomyopathy Uncovers Alterations in Heart Development [0.03%]
整合甲基组和转录组分析在慢性查加斯心脏病中发现了心脏发育改变
Francisco Heredia-Fernández,Javier Martínez-López,Laura C Terrón-Camero et al.
Francisco Heredia-Fernández et al.
Background: Chagas disease, caused by Trypanosoma cruzi, remains a health concern worldwide. Its most severe clinical outcome, chronic Chagas cardiomyopathy (CCC), is marked by progressive cardiac dysfunction. Biological ...
RNAemia and Severe COVID-19: Candidate Treatment Targets Identified Through Transcriptomics [0.03%]
新冠肺炎重症与血液中的RNA：通过转录组学识别潜在治疗目标
Sultanah Alharthi,Nusrat J Epsi,David A Lindholm et al.
Sultanah Alharthi et al.
Introduction: The presence of SARS-CoV-2 RNA in blood has been proposed as a marker of severe COVID-19, but it is unclear whether RNAemia mediates the pathway toward worsening disease. We hypothesized that RNAemia is asso...
Correspondence to "Indirect Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Colonization: Persistence and Dynamics of Vaccine Serotypes in Sicily (Italy) 11 Years Postintroduction, 2009-2020" by Tramuto et al [0.03%]
Tramuto等关于“肺炎球菌结合疫苗对肺炎球菌定植的间接影响：意大利西西里岛2009-2020年引入后11年间疫苗血清型的持续性和动态变化”的信件答复
Willem R Miellet,Sónia T Almeida,Raquel Sá-Leão et al.
Willem R Miellet et al.
CD4+ T cell markers associated with Treatment Outcomes in Tuberculosis: A Sub-analysis of a Phase IIB Trial of Acetylsalicylic acid and Ibuprofen as Adjunctive Therapy [0.03%]
乙酰水杨酸和布洛芬作为结核病辅助治疗的IIb期临床试验的亚组分析：与疗效相关的CD4+T细胞标志物
Noelia Alonso-Rodríguez,Iselin Høgbakk Edlund,Hans Christian Dalsbotten Aass et al.
Noelia Alonso-Rodríguez et al.
Background: Adjunctive host-directed therapies (HDT) may improve treatment outcomes in tuberculosis (TB). Affordable repurposed drugs can be quickly implemented in clinical practice; however, predictive biomarkers are ess...