Fc-fucosylation of Plasmodium falciparum-specific IgG varies with antigen and immunization [0.03%]
疟原虫株特异性IgG的岩藻糖基化与抗原及免疫化处理方式相关
Frederica Dedo Partey,Maria Ines Dos Santos,Zakaria Seidu et al.
Frederica Dedo Partey et al.
Background: IgG-mediated effector functions are modulated by the antibody Fc-region glycan composition, and the absence of core fucose is a strong modifier of NK cell-mediated antibody-dependent cellular cytotoxicity (ADC...
Colleen S Kraft,Jill S Morgan
Colleen S Kraft
Discriminating Bacterial from Nonbacterial Lower Respiratory Tract Infection within Clinical Subgroups of Hospitalized Adults [0.03%]
在住院成人临床亚组中区分细菌性和非细菌性下呼吸道感染
Ann R Falsey,Derick R Peterson,Andrea M Baran et al.
Ann R Falsey et al.
We previously identified a blood-based 4-gene signature that accurately discriminates bacterial from nonbacterial acute respiratory infection (ARI) in 504 hospitalized adults (AUC = 0.90). Here we evaluate how well this global signature per...
Birth cohort effects in adults associated with influenza A(H1N1)pdm09 vaccine effectiveness [0.03%]
与甲型H1N1流感疫苗效力有关的成年人群出生队列效应
Feng Liu,F Liaini Gross,Zhunan Li et al.
Feng Liu et al.
Background: In the 2023-24 influenza season, adults born in the 1957-1985 birth cohort had the lowest vaccine effectiveness (VE) against A(H1N1)pdm09 viruses than other age groups, including those in the 1986-2005 birth c...
Concomitant liver steatosis in chronic HBV infection is linked to a distinct cytokine profile and reduced viral load [0.03%]
慢性HBV感染伴发肝脂肪变与特异性细胞因子谱型和较低的病毒载量相关
Katharina John,Marie-Louise Voss,Sherin Al Aoua et al.
Katharina John et al.
Background and aims: Chronic hepatitis B virus (HBV) infection coexists with liver steatosis in about one third of cases. Increasing evidence indicates that concomitant liver steatosis contributes to liver disease progres...
Molecular Epidemiology to Decipher the Transmission Networks of MPOX in an Outbreak Scenario: Applications in Thailand during the 2023 Global Health Emergency [0.03%]
分子流行病学解码猴痘疫情传播网络：2023年全球卫生紧急情况下的泰国应用研究
Spencer L Sterling,Kwankamon Rattanathumi,Thitipong Yingyong et al.
Spencer L Sterling et al.
Background: The 2022 global health emergency highlighted the necessity for rapid diagnostic measures in response to Mpox clade IIb outbreaks. This study investigates the Mpox lineages identified in Thailand during this pe...
What is the optimal RSV immunisation strategy for infants born in the RSV off-season? [0.03%]
RSV淡季出生的婴儿的最优RSV免疫策略是什么？
Hannah C Moore,Damien Foo,Fiona Giannini et al.
Hannah C Moore et al.
We explored age-specific infant RSV laboratory-confirmed hospitalisation rates by birth month in Western Australia. Population-based analyses were supplemented with a Susceptible-Exposed-Infected-Recovered-(Susceptible) mathematical model s...
Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases from Household Microbiological and Clinical Data [0.03%]
基于家庭微生物学和临床数据估计霍乱患者和无症状感染者传播力
Claire P Smith,Justin Lessler,Sonia T Hegde et al.
Claire P Smith et al.
Background: In Bangladesh, cholera treatment focuses on acute watery diarrhea in symptomatic cases at health facilities, though asymptomatic infections are common. Understanding the role of asymptomatic infections in tran...
Post-COVID rebound in invasive pneumococcal disease driven by resurgence of serotype 4 among American Indian individuals in the Southwest United States [0.03%]
美国西南部印第安人中由4血清型肺炎球菌复苏引起的COVID后侵袭性肺炎球菌病反弹
Catherine G Sutcliffe,Victoria M Sergent,Del Yazzie et al.
Catherine G Sutcliffe et al.
Background: Incidence of invasive pneumococcal disease (IPD) in American Indian (AI) communities in the Southwest US declined during the COVID-19 pandemic. We estimated the burden and serotype distribution of IPD in the s...
HIV-1 APOBEC-context mutations detected by next-generation sequencing in plasma: implications for drug resistance interpretation [0.03%]
基于下一代测序技术在血浆中检测与HIV-1APOBEC相关的突变及其对病毒耐药性分析的影响
Marta Illescas-López,Paloma Muñoz,Adolfo de Salazar et al.
Marta Illescas-López et al.
Background & aims: APOBEC3-mediated cytidine deamination produces characteristic G→A substitutions in HIV genomes, classically described in proviral DNA but also detectable in plasma HIV-1 RNA using next-generation seque...