lPrediction of Vancomycin Area-under-the-curve using Trough Concentrations Only: Performance Evaluation of Pediatric Population Pharmacokinetic Models [0.03%]
仅用谷浓度预测万古霉素面积下的曲线：儿科人群药代动力学模型的性能评估
Stef Schouwenburg,Tim Preijers,Robert B Flint et al.
Stef Schouwenburg et al.
Objectives: In pediatric patients, vancomycin plays a pivotal role in combating infections, necessitating precise therapeutic drug monitoring to ensure efficacy and safety. The adoption of model-informed precision dosing ...
GABA-induced monocytic reactive oxygen species impair CD4 restoration in treated HIV-1 adults [0.03%]
GABA诱导的单核细胞反应性氧损伤治疗HIV-1成人中的CD4恢复
Mehwish Younas,Sandrine Gimenez,Yea-Lih Lin et al.
Mehwish Younas et al.
Background: In order to better understand why about 15% of people living with Human Immunodeficiency Virus-1 (PWH) on highly active antiretroviral therapy do not restore their CD4 count, we explored the link previously re...
Circulating Soluble Factors and T-Cell Subsets as Immunological Predictors of Therapy Response in Human Cutaneous Leishmaniasis [0.03%]
人类皮肤利什曼病治疗反应的免疫学预测指标：循环可溶性因子和T细胞亚群
Amanda B Figueiredo,Katia L P Morais,Israel T Silva et al.
Amanda B Figueiredo et al.
Background: Human cutaneous leishmaniasis, a neglected tropical disease caused by Leishmania braziliensis, presents treatment challenges due to varying therapeutic responses. Current therapies often encounter limited effi...
Molecular characterization of RSV infections in elderly patients during the 2023/2024 season in the era of nirsevimab introduction [0.03%]
nirsevimab时代背景下RSV感染的分子特征——以老年患者为例(2023-2024年度)
Amandine Caillault,Laurent Softic,Pierre Bay et al.
Amandine Caillault et al.
RSV can cause severe infections in the elderly. Nirsevimab is a novel prophylactic monoclonal antibody, widely used in infants in France during the 2023/2024 season. It may select for resistant RSV variants that, if transmitted in the commu...
Characterization of c-Src during Listeria monocytogenes cell-to-cell spreading [0.03%]
>Listeria monocytogenes 细胞间扩散过程中c-Src的特征分析
Petra McLeod,Aaron S Dhanda,Julian A Guttman
Petra McLeod
Listeria monocytogenes replicates within host cells and spreads from cell-to-cell using actin-based motility. Cell-to-cell movement of L. monocytogenes is achieved by creating actin-rich membrane protrusions (listeriopods), which generate c...
Pandemic preparedness: analyzing national plans for respiratory pathogen pandemics in the Americas region [0.03%]
大流行病准备工作：美洲地区呼吸道传染病大流行国家计划分析
Andrea Patricia Villalobos,Iyanna Wellington,Shoa Moosavi et al.
Andrea Patricia Villalobos et al.
Background: The International Health Regulations (2005) (IHR), requires that States Parties develop their capacities to detect, assess, and respond to public health threats and report to the World Health Assembly through ...
Influenza vaccine averted illnesses in Chile, Guyana, and Paraguay during 2013-2018: a standardized approach to assess value of vaccination [0.03%]
标准化评估疫苗接种价值的方法：2013-2018年流感疫苗使智利、圭亚那和巴拉圭避免了多种疾病
Jorge H Jara,Sergio Loayza,Francisco Nogareda et al.
Jorge H Jara et al.
Background: To better establish the value of vaccination against influenza viruses, we estimated vaccine-averted influenza illnesses among young children and older adults in Chile, Guyana, and Paraguay. ...
A Comparative Analysis of Universal and Sentinel Surveillance Data for COVID-19: Insights from Argentina, Chile, and Mexico (2020-2022) [0.03%]
基于阿根廷、智利和墨西哥（2020-2022）的新冠数据，对通用监测与哨点监测进行比较分析
Lidia Redondo-Bravo,Kinda Zureick,Carla Jimena Voto et al.
Lidia Redondo-Bravo et al.
Background: In 2020, countries implemented universal surveillance to detect and monitor SARS-CoV-2 cases. Although crucial for early monitoring efforts, universal surveillance is resource intensive. To understand the impl...
Strengthening the Surveillance and Response to Public Health Events with a One Health approach: a perspective from 12 countries in Latin America and the Caribbean [0.03%]
从拉美及加勒比12国看“同一健康”方法下的公共卫生事件监测与应对能力建设展望
Angel Rodriguez,Paula Couto,Alejandra Acevedo et al.
Angel Rodriguez et al.
Annual estimation of seasonal influenza burden in six South American countries: a retrospective analysis of SARInet surveillance data to inform policies [0.03%]
六个国家的季节性流感疾病负担估算：基于SARInet监测数据的回顾性分析以制定政策
Miguel Angel Descalzo,Francisco José de Paula Júnior,Natalia Vergara Mallegas et al.
Miguel Angel Descalzo et al.
Background: We estimate annual viral influenza-associated mild-to-moderate illness, hospitalizations, and deaths in six South American countries (Argentina, Brazil, Chile, Ecuador, Paraguay, and Uruguay) during the 2015-2...