Maternal cytomegalovirus serology results by geographic region in a large multicenter United States study [0.03%]
一项大型美国多中心研究中各地区的产妇巨细胞病毒血清学结果
Brenna L Hughes,Cora MacPherson,Dwight J Rouse et al.
Brenna L Hughes et al.
Congenital cytomegalovirus (CMV) infection, due to both nonprimary and primary maternal infection, affects nearly 1% of neonates. In conducting a randomized trial of hyperimmune globulin for prevention of congenital CMV infection, we screen...
First-in-Human Evaluation of the Safety, Genetic Stability, and Immunogenicity of an Attenuated Shigella flexneri 2a Live Vector Expressing Enterotoxigenic Escherichia coli Antigens, Vaccine Strain CVD 1208S-122 [0.03%]
沙门氏菌伤寒载体疫苗减毒活疫苗CVD 1208S-122首次用于人体的I/II期临床试验：安全性和免疫原性研究
Wilbur H Chen,Eileen M Barry,Franklin R Toapanta et al.
Wilbur H Chen et al.
Background: There are no licensed vaccines to protect against Shigella or enterotoxigenic Escherichia coli (ETEC), yet they are among the most common causes of bacterial diarrhea. We engineered an attenuated S. flexneri 2...
Human genetic variation associates with infection by derived Ugandan M. tuberculosis lineage [0.03%]
人类遗传变异与乌干达衍生结核分枝杆菌菌株感染相关性研究
Catherine M Stein,Penelope Benchek,Lentlamatse Mantshoyane et al.
Catherine M Stein et al.
Background: Several studies have examined host and pathogen genetic influences on tuberculosis (TB) susceptibility separately, but relatively few studied their combined effects. However, host-pathogen interactions or co-e...
Bacterial dysbiosis, cervicovaginal human papillomaviruses and inflammation persist in women living with HIV-1 after a year of antiretroviral treatment [0.03%]
HIV-1患者接受一年抗逆转录病毒治疗后细菌菌群失调、宫颈阴道乳头瘤病毒感染和炎症仍然持续存在
Andrea Lisco,Alessandra Borgognone,Christophe Vanpouille et al.
Andrea Lisco et al.
Background: The cervicovaginal microbiome may affect HIV-1 susceptibility and can in turn influence the prevalence and clinical course of HIV-1 and other sexually transmitted diseases. As the determinants, immunological c...
Tearing down the wall: emu-miR-745-3p in Echinococcus multilocularis exosomes attenuates host liver fibrosis to permit invasive lesion development [0.03%]
打破壁垒：Echinococcus multilocularis外泌体中的emu-miR-745-3p减轻宿主肝纤维化以促进侵袭性病变的形成
Ning Yang,Hongbin Zhang,Bowen Shi et al.
Ning Yang et al.
Background: Alveolar echinococcosis (AE), caused by Echinococcus multilocularis (E. multilocularis), exhibits tumor-like, invasive growth in the liver. Unlike cystic echinococcosis, AE lesions are often bordered by loose ...
Age-dependent clinical and molecular rhinovirus epidemiology, 2018 to 2023 [0.03%]
2018至2023年rhinovirus的年龄依赖性临床和分子流行病学特征
Ilka Engelmann,Amandine Pisoni,Clara Mille et al.
Ilka Engelmann et al.
Objectives: Respiratory viruses show different circulation patterns. While influenza and respiratory syncytial virus epidemiology is well documented, the epidemiology of other respiratory viruses is less reported. ...
Tuberculosis Disease Severity Assessment Using Clinical Variables and Radiology Enabled by Artificial Intelligence [0.03%]
基于人工智能的临床及影像变量评估肺结核病情严重程度的研究
Marwan Ghanem,Ratnam Srivastava,Yasha Ektefaie et al.
Marwan Ghanem et al.
Background: Chest X-ray (CXR) can assess pulmonary tuberculosis (TB) severity and may guide duration of treatment. However, the optimal radiological metric and its integration with clinical variables for predicting treatm...
A first-in-human phase 1 clinical study in healthy volunteers to assess the safety, tolerability and pharmacokinetics of EDI048, a novel promising agent to treat enteric cryptosporidiosis [0.03%]
EDI048首次人体1期临床研究：在健康志愿者中评估新型肠易感染隐孢子虫病治疗药物的安全性、耐受性和药代动力学特征
Monish Jain,Kristen Stevenson,Anais Cheblal et al.
Monish Jain et al.
Background: Cryptosporidiosis is a major diarrheal disease with significant morbidity and mortality in young and malnourished children from low- and middle-income countries. EDI048 is a novel Cryptosporidium PI(4)K inhibi...
Neurodevelopment in children exposed to antenatal CMV viraemia in a high HIV prevalence area [0.03%]
高HIV流行地区宫内感染巨细胞病毒儿童神经发育状况研究
Ceri Evans,Jaya Chandna,Kuda Mutasa et al.
Ceri Evans et al.
We compared neurodevelopment at age 24-months among children born to mothers with or without CMV viraemia in the third trimester of pregnancy in rural Zimbabwe, using the Malawi Developmental Assessment Tool (MDAT) for gross motor, fine mot...
Asymptomatic screening for Neisseria gonorrhoeae among gay and bisexual men attending public sexual health services in Australia and associations with patterns of ceftriaxone consumption: a retrospective observational study [0.03%]
在澳大利亚面向男男性行为者的公共卫生服务中心对无症状淋病筛查及与罗氏芬消耗模式相关性的回顾性观察研究
Arthur Wong,Htein Linn Aung,Rick Varma et al.
Arthur Wong et al.
Background: Neisseria gonorrhoeae is a significant public health concern due to rising antimicrobial resistance (AMR). Current strategies for N.gonorrhoeae among GBM include frequent (3-monthly) screening however, high-fr...