Translational modeling of BTZ-043 in predicting phase IIA efficacy and evaluating drug-drug interactions with BPaL in murine models [0.03%]
BTZ-043在预测二期A疗效和评估murine模型中BPaL药物相互作用的转化模型研究
Bernard Ngara,Lorenzo Flori,Rob Christiaan van Wijk et al.
Bernard Ngara et al.
Introduction: BTZ-043 is a promising novel drug candidate for anti-tuberculosis treatment. This study aimed to apply a previously developed mouse-to-human translational modeling platform for anti-tuberculosis drugs to pre...
Reply to Wang and Zhang [0.03%]
答王、张二君
Mudsser Azam,Ruchi Singh
Mudsser Azam
RNA-Seq analysis in macrophages infected with Trypanosoma cruzi: focus on TLR2 and TLR7, iron metabolism, and extracellular matrix biosynthesis [0.03%]
克氏锥虫感染的巨噬细胞中的RNA-Seq分析：关注TLR2和TLR7，铁代谢及细胞外基质生物合成
Francisco Callejas-Hernández,Alfonso Herreros-Cabello,Cristina Poveda et al.
Francisco Callejas-Hernández et al.
Introduction: Trypanosoma cruzi is a protozoan parasite responsible for Chagas disease affecting millions globally. This parasite infects mammalian host cells, particularly macrophages. The interaction between T. cruzi an...
Lilliam Ambroggio,Todd A Florin,Kayla Williamson et al.
Lilliam Ambroggio et al.
Background: Accurate diagnosis of community-acquired pneumonia (CAP) can be challenging. Clinical findings are non-specific, and interpretations of chest radiographs have poor inter-rater reliability. Pilot studies demons...
High prevalence of ceftriaxone-resistant Neisseria gonorrhoeae in Hanoi, Vietnam, 2023-2024 [0.03%]
越南河内2023-2024年期间淋病奈瑟菌对头孢曲松耐药率高
Jolein Gyonne Elise Laumen,Vu N Hieu,Pham H Nhung et al.
Jolein Gyonne Elise Laumen et al.
Ceftriaxone resistance in Neisseria gonorrhoeae is an escalating global health concern, threatening the efficacy of empiric treatment. In the Asia-Pacific region, a rapid surge in ceftriaxone resistance has been observed, primarily associat...
Prevalence of Plasmodium falciparum drug resistance markers pfcrt K76T and pfaat1 S258L in southern Rwanda, 2010 to 2023 [0.03%]
2010至2023年卢旺达南部恶性疟原虫耐药基因pfcrt K76T和pfaat1 S258L的流行情况
Emma Schallenberg,Welmoed van Loon,Djibril Mbarushimana et al.
Emma Schallenberg et al.
Background: In many countries in Sub-Saharan Africa, the Plasmodium falciparum chloroquine resistance marker pfcrt K76T disappeared within a decade of ceased chloroquine use. Pfaat1 S258L has recently been implicated as a...
Azithromycin as host-directed therapy for pulmonary tuberculosis - a randomized pilot trial [0.03%]
阿奇霉素用于肺结核的宿主导向治疗：一项随机试点试验
Bart G J Dekkers,Huib A M Kerstjens,Helene W Breisnes et al.
Bart G J Dekkers et al.
Background: Adjunctive host-directed therapies are investigated that modulate host immune responses to reduce excessive inflammation and prevent tissue damage in tuberculosis (TB). Macrolides, including azithromycin, were...
Pharmacokinetics and safety of clofazimine in children with rifampicin-resistant tuberculosis [0.03%]
氯法齐明儿科药代动力学及安全性研究-利福平耐药结核病儿童患者中的一项开放标签、单臂多中心试验
Jennifer A Hughes,Belén P Solans,Anthony J Garcia-Prats et al.
Jennifer A Hughes et al.
Background: Paediatric pharmacokinetic and safety data for clofazimine are limited. We described the pharmacokinetics and safety of clofazimine in South African children treated for multidrug/rifampicin-resistant tubercul...
Sarah S Jackson,Julia Francis,Ruth M Pfeiffer et al.
Sarah S Jackson et al.
We investigated anti-EBV IgA and IgG responses by sex among 387 cancer-free individuals in Asia. Antibody responses were measured using an EBV proteome array to assess age-adjusted sex-specific associations with 404 EBV-antigens in 86 prote...
Journal of the Pediatric Infectious Diseases Society and the Journal of Infectious Diseases Collaboration: The First Fruits From a New Tree [0.03%]
儿科感染病学会杂志与感染病学会杂志合作刊文：新树结出第一枚果实
Ravi Jhaveri,Cynthia L Sears
Ravi Jhaveri