Proactive Surveillance of Public Swimming Pools to Prevent Delayed Detection of Cryptosporidiosis Outbreaks [0.03%]
主动监测公共游泳池以防止隐孢子虫暴发的延迟发现
Seak Lin Ly,Marielle Babineau,Jane McAllister et al.
Seak Lin Ly et al.
Background: Swimming pool-related cryptosporidiosis outbreaks are a global issue disproportionately affecting young children. This study aimed to (1) quantify swimming pool outbreak detection timelines; (2) identify patho...
Diverse genetic lineages spreading across healthcare and community boundaries underlie extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) colonization burden in Botswana [0.03%]
博茨瓦纳的extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE)定植负担跨越医疗和社区界限并衍生出多种遗传谱系
Tiffany Wan,Ebbing Lautenbach,Naledi Mannathoko et al.
Tiffany Wan et al.
Objectives: Although extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) are a global health challenge, molecular data from low- and middle-income countries are limited. We employed whole-genome sequencing ...
Gerco den Hartog,Rosemary Rochford
Gerco den Hartog
NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris [0.03%]
痤疮丙酸杆菌临床分离株诱发NETs的能力与其致病性正相关
Yi-Hsien Shih,Chih-Chieh Hsu,Che-Hao Hsu et al.
Yi-Hsien Shih et al.
Background: Cutibacterium acnes strains vary in virulence and inflammatory potential in acne vulgaris, but the role of the bacterial ability to induce neutrophil extracellular traps (NETs) in acne is unclear. ...
Optimizing the Use of Proviral DNA HIV Drug Resistance Testing: Clinical Applications and Cautions [0.03%]
优化HIV前病毒DNA药物敏感性测定的临床应用及注意事项
Lillian Seo,Roger Paredes,Rami Kantor
Lillian Seo
Monitoring HLA-A2-restricted T cell responses and BCLA-specific serostatus during human latent Toxoplasma gondii infection suggests the implication of CD8+ T cells in parasite containment [0.03%]
在人类潜伏性弓形虫感染期间监测HLA-A2限制性T细胞反应和BCLA特异性血清状态，提示CD8+ T细胞在寄生虫限制中的作用
Raphaëlle Romieu-Mourez,Pierre Emmanuel Paulet,Emilie Bassot et al.
Raphaëlle Romieu-Mourez et al.
Background: T cells are critical to control Toxoplasma gondii (T. gondii) parasite infection. Yet, our understanding of T. gondii-specific CD8+ T cell responses in humans remains scarce. Here, we studied 56 HLA-A2+ health...
Cryptosporidiosis in Ptients with Inborn Errors of Immunity: Retrospective cohort study of the French National Reference Center (CEREDIH) [0.03%]
法国国家参考中心(CEREDIH)先天性免疫缺陷患者隐孢子虫病的回顾性队列研究
Deborah To Puzenat,Morgane Cheminant,Eric Dannaoui et al.
Deborah To Puzenat et al.
Background: Inborn Errors of Immunity (IEI) display increased susceptibility to infections among which cryptosporidiosis is an opportunistic infection poorly characterized in this population. We report cases of Cryptospor...
Type 3 fimbrial regulation underpins anti-MrkA immunotherapeutic efficacy in experimental Klebsiella pneumoniae infection [0.03%]
调节型3型菌毛调控决定了抗MrkA免疫治疗在实验性肺炎克雷伯菌感染中的疗效
Julia Sanchez-Garrido,Sophia David,Jaie Rattle et al.
Julia Sanchez-Garrido et al.
Background: Klebsiella pneumoniae (KP) is a critical-priority organism due to prevalent last-line antibiotic resistance. Alternative treatments, including vaccines and monoclonal antibodies (mAb), depend on antigen (Ag) e...
Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals [0.03%]
金黄色葡萄球菌菌血症异质性的研究进展与未来展望
Clark D Russell,Sofía De La Villa,Maaike C Swets et al.
Clark D Russell et al.
Clinical and biological heterogeneity in Staphylococcus aureus bacteraemia (SAB) continue to pose significant challenges for the clinical management of individual patients and for research efforts. We contend that investigating SAB as a sin...