Investigation of correlates of protection against gonococcal infection by comparative immunoprofiling of responses in experimental and clinical studies [0.03%]
通过实验和临床研究的免疫谱系比较分析gonococcal感染保护相关因素的研究
Samantha A McKeand,Fidel Ramirez Bencomo,Anthony Soc et al.
Samantha A McKeand et al.
Background: Neisseria gonorrhoeae is an important cause of sexually transmitted infection with rising antimicrobial resistance. Epidemiological studies suggest that vaccines containing meningococcal outer membrane vesicle...
Schistosoma mansoni Infections Are Associated With Fecal Calprotectin Markers of Gut Inflammation After Accounting for HIV, Hepatitis B, and Malaria [0.03%]
排除HIV、乙型肝炎和疟疾的影响后，曼氏血吸虫感染与粪便钙卫蛋白标记的肠道炎症有关
Lauren Wilburn,Hanh Lan Bui,Paul Akampurira et al.
Lauren Wilburn et al.
Background: The role of gut inflammation for intestinal schistosomiasis remains poorly understood in chronically infected and repeatedly treated populations. ...
Lakshmi Chauhan,Debashis Ghosh,Beau Ances et al.
Lakshmi Chauhan et al.
People with HIV (PWH) have an earlier occurrence of aging complications, including cognitive impairment (CI). Chronic immune activation from cytomegalovirus (CMV) may contribute to increased inflammation and CI. We explored this association...
Decreased persistence of maternal antibodies in infants who are HIV-exposed and uninfected [0.03%]
感染人类免疫缺陷病毒但未感染的人体婴儿母体抗体的持续时间缩短
Yiwei Jiang,Tessa Goetghebuer,Stefan Embacher et al.
Yiwei Jiang et al.
Background: Infants who are HIV-exposed uninfected (iHEU) are more susceptible to severe infections in the first months of life compared with infants who are HIV-unexposed (iHU). Previous studies showed an association wit...
Vancomycin-resistant Enterococcus often spreads from hospitalized patients into the local environment and less often spreads from the environment into patients [0.03%]
万古霉素耐药肠球菌往往由住院患者传播到当地环境，较少由环境传播给患者
Dwayne Seeram,Heekuk Park,Julian A Abrams et al.
Dwayne Seeram et al.
Background: Uncertainty remains about how gut-based organisms such as vancomycin-resistant Enterococcus (VRE) are spread within the local hospital environment. We hypothesized that, in the medical intensive care unit (ICU...
In Host Mutational Adaptation of Mycobacterium Tuberculosis Complex Strains During Tuberculosis Infection [0.03%]
结核分枝杆菌复合群菌株在感染过程中适应性突变特征研究
Helen Zhang,Naomi Medina-Jaudes,Alicia Forcada-Nadal et al.
Helen Zhang et al.
Background: Tuberculosis (TB) is the leading cause of death from an infectious disease worldwide. Mutations arising in Mycobacterium tuberculosis complex (MTBC) strains during TB infection provide a record of bacterial ad...
Effect of Delayed Antiretroviral Therapy Initiation on Anti-CD4 Autoantibodies in Antiretroviral Therapy-Naïve People With HIV [0.03%]
人类免疫缺陷病毒感染且未接受抗逆转录病毒治疗者延迟开始抗逆转录病毒治疗对反CD4自身抗体的影响
Brian P Epling,Shweta Mistry,Birgit Grund et al.
Brian P Epling et al.
Background: We previously identified anti-CD4 autoantibodies in antiretroviral therapy (ART)-naïve people with HIV (PWH) with CD4500 cells/µL were randomized to start ART immediately (immediate) or delay until CD4
Effects of age and birth cohort on influenza A virus subtype-specific hospitalization rates, United States 2010-2025 [0.03%]
年龄和出生队列对美国2010-2025年流感A病毒亚型特异性住院率的影响
Alissa O&#x;Halloran,Nicole Hood,Dawud Ujamaa et al.
Alissa O&#x;Halloran et al.
Background: Older individuals (≥65 years) are at greatest risk of severe influenza requiring hospitalization. Since 2009, influenza-associated hospitalization rates during A(H1N1)pdm09-predominant influenza seasons have ...
"Intranasal vaccination with recombinant human adenovirus encoding the trans-sialidase gene protects mice from lethal subcutaneous and oral Trypanosoma cruzi trypomastigote challenges" [0.03%]
“表达克鲁兹锥虫转糖基酶基因的人5型腺病毒鼻黏膜免疫小鼠诱导对克鲁兹锥虫的保护性免疫反应”
Isaú Henrique Noronha,Liana Nanako Wada,Barbara Santos Rossetto et al.
Isaú Henrique Noronha et al.
Background: The majority of new cases of Chagas' disease, caused by Trypanosoma cruzi, have been associated with oral infection. Thus, it is reasonable that any vaccine formulation developed should elicit systemic and muc...
The tyrosine kinase receptor EphA2 in alveolar macrophages provides a protective role in host defense against Pneumocystis pneumonia [0.03%]
肺泡巨噬细胞中的酪氨酸激酶受体EphA2在宿主防御间质肺炎中发挥保护作用
Theodore J Kottom,Madeline Pellegrino,Conrad Achilonu et al.
Theodore J Kottom et al.
Background: Alveolar macrophages (AMs) are central to host defense against Pneumocystis, mediating organism clearance while also contributing to lung inflammation. EphA2, a transmembrane receptor that binds fungal β-gluc...