Targeting the disease response with NlpD and LytM for effective non-antibiotic treatment of urinary tract infections [0.03%]
靶向疾病反应利用NlpD和LytM进行有效的非抗生素泌尿系统感染治疗
Hien Thi Tran,Inês Gomes,Arunima Chaudhuri et al.
Hien Thi Tran et al.
Background: Finding new ways of treating bacterial infections is essential. The NlpD protein, which inhibits RNA Polymerase II (Pol II), has shown therapeutic efficacy against urinary tract infection. This study investiga...
Hydrogen cyanide generation by Pseudomonas aeruginosa blunts the host innate immune response [0.03%]
铜绿假单胞菌通过生成氢氰酸来抑制宿主的先天免疫反应
Csaba Szabo,Sidnéia Sousa Santos,Jacqueline Findlay et al.
Csaba Szabo et al.
Background: The biological mediator hydrogen cyanide (HCN) is produced by certain pathogenic bacteria. HCN exerts multiple effects in mammalian cells: at low concentrations it has cytoprotective regulatory effects, wherea...
Genomic surveillance of human metapneumovirus in the United States, 2010-2025 [0.03%]
美国呼吸道合胞病毒的人群基因组监测（2010—2025年）
Emily E Bendall,William J Fitzsimmons,Weronika Damek Valvano et al.
Emily E Bendall et al.
Background: Human metapneumovirus (HMPV) is a significant cause of acute respiratory illness in both children and adults, yet its genomic epidemiology remains understudied compared to other respiratory viruses. ...
Enterotoxigenic Bacteroides fragilis induces host genotype-specific colonic epithelial and immune responses in mice [0.03%]
脆弱类杆菌肠毒素诱导小鼠结肠上皮和免疫反应的宿主基因型特异性响应
Taylor Southward,Yongbao Zhuang,Ada Tam et al.
Taylor Southward et al.
Background: Colorectal cancer pathogenesis involves complex interactions between multiple risk factors including somatic mutations and microbial dysbiosis. A number of individual microbiota members have been implicated in...
Utility of nasopharyngeal aspirate over other upper airway sampling approaches for cellular immunology during respiratory viral infection [0.03%]
呼吸道病毒感染期间鼻咽吸引物标本优于其他上呼吸道标本采集方法进行细胞免疫学检测的价值评估
Sara Falck-Jones,Björn Österberg,Eric Åhlberg et al.
Sara Falck-Jones et al.
Early immune responses to respiratory viruses in the upper airways, including recruitment of innate immune cells like monocytes and dendritic cells (DCs), dictate disease development. Still, unlike soluble biomarkers, comparative evaluation...
Structure-guided design of calcium-dependent protein kinase 1 (CDPK1) inhibitors for cryptosporidiosis [0.03%]
结构导向的抗隐孢子虫病钙依赖性蛋白激酶1(CDPK1)抑制剂的设计
Wissarut Wijitrmektong,Ryan Choi,Matthew A Hulverson et al.
Wissarut Wijitrmektong et al.
Background: Calcium-dependent protein kinase 1 (CDPK1) has emerged as a protozoan specific target for the treatment of cryptosporidiosis. A previous study identified pyridopyrimidinones as new Cryptosporidium parvum (Cp) ...
Protocols for Randomized Controlled Trials: Advancing Transparency in Infectious Diseases [0.03%]
传染病领域随机对照试验方案的透明化报告标准 advancements:protocols for randomized controlled trials: advancing transparency in infectious diseases
Jean-Jacques Parienti,Roger Bedimo,Cynthia L Sears et al.
Jean-Jacques Parienti et al.
Diagnostic Methods for Cryptosporidiosis in Low- and Middle-Income Countries: A Systematic Narrative Review [0.03%]
发展中国家隐孢子虫病诊断方法系统评价：叙述性综述
Tewachew Awoke,Asnake Simieneh,Fregenet Tesfaye et al.
Tewachew Awoke et al.
Background: Cryptosporidiosis is a major cause of diarrheal disease in low- and middle-income countries (LMICs), yet access to diagnostic testing is limited. Evidence on the diagnostic accuracy and operational feasibility...
High Nasopharyngeal SARS-CoV-2 Load and Delayed Clearance in Hospitalized Patients With Blood Autoantibodies Neutralizing Type I Interferons [0.03%]
血液I型干扰素中和自身抗体阳性患者的高鼻咽部SARS-CoV-2病毒载量及清除延迟现象
Astrid Marchal,Thibault Kerdiles,Aglaé Perrin et al.
Astrid Marchal et al.
Autoantibodies neutralizing type I interferon (AAN-I-IFNs) underlie life-threatening COVID-19. In hospitalized COVID-19 patients of the DisCoVeRy trial (NCT-04315948), AAN-I-IFNs were associated with higher nasopharyngeal viral load at incl...