Finding and managing a mentorship team: Tips for success for early career infectious diseases physician-scientists [0.03%]
寻找并管理导师团队：初级传染病医学生物学家成功建议
Russell R Kempker,Dawn Comeau,Alison G C Smith et al.
Russell R Kempker et al.
Effective mentorship is vital to engage and develop physician-scientists in the field of infectious diseases (ID). We provide guidance for early career physician-scientist mentees to help them find, develop, and manage a mentor team. Import...
Derivation and validation of clinical prediction models for Cryptosporidium-attributed acute diarrhea in African children [0.03%]
非洲儿童隐孢子虫病归因急性腹泻的临床预测模型的派生和验证
Léna Mazza,Ben J Brintz,M Jahangir Hossain et al.
Léna Mazza et al.
Background: Clinical decision-support tools have the potential to guide empiric treatment and prioritize diagnostic testing at the individual-level, and screening strategies for vaccine and therapeutic trials at the popul...
Sampling and host-strain interactions shape detection of Staphylococcus aureus transmission in hospitals [0.03%]
抽样和宿主菌株互作决定了医院中检测到的金黄色葡萄球菌传播状况
Kristine B Rabii,Courtney Takats,Gregory Putzel et al.
Kristine B Rabii et al.
Background: In principle, whole-genome sequencing of Staphylococcus aureus in hospitals is most effective when used prospectively, but its practical limits are unclear. ...
An Intracisternal Rabbit Model Reveals Treponema pallidum Egress Across an Intact Blood-Brain Barrier [0.03%]
一个兔脑室内模型揭示了苍白螺旋体在完整血脑屏障上的逸出现象
Shu-Hao Fan,Lin Xie,Yue Zhong et al.
Shu-Hao Fan et al.
Background: Treponema pallidum (T. pallidum), the causative agent of syphilis, can invade the central nervous system (CNS) during early infection. However, whether blood-brain barrier (BBB) disruption is required for spir...
Impact of early antiretroviral treatment on tissue resident memory CD4+ T cells in the gastrointestinal tract [0.03%]
早期抗逆转录病毒治疗对胃肠道驻留记忆CD4+T细胞的影响
Sinmanus Vimonpatranon,Aloysious Ssemaganda,Yuwadee Phuang-Ngern et al.
Sinmanus Vimonpatranon et al.
Background: Tissue resident memory CD4+ T cells (CD4+ TRM) are long-lived, seldom-circulating cells that reside for long periods in most tissues. TRM can mount rapid, antigen-specific responses to pathogens and contribute...
Multibead-based immunoassay provides one-step species-specific serodiagnosis of filarial infections and Strongyloides stercoralis in travelers and immigrants [0.03%]
多珠基免疫测定法可一步诊断旅行者和移民的丝虫感染及毛尾线虫病
Miranda Yu,Joseph Kubofcik,Trinity Obiorah et al.
Miranda Yu et al.
Background: Previously, antifilarial antibody testing in the evaluation of returned travelers and immigrants to North America has relied on IgG- and IgG4-specific responses to crude filarial extracts (BmA), tests that suf...
Afucosylated VAR2CSA-Specific IgG Reduces Risks of Placental Malaria [0.03%]
Afucosylated VAR2CSA特异性IgG可降低胎盘疟疾风险
Honghua Ding,Oscar H Lloyd Williams,Maria Saeed et al.
Honghua Ding et al.
Background: Antibody Fc regions have important roles in clearance of Plasmodium falciparum-infected erythrocytes. One such role is engagement with Fcγ receptors on host leukocytes. In the case of FcγRIIIa and b, this in...
Randomized, Double-Blind, Placebo-Controlled First-in-Human Trial of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix [0.03%]
一种新型人工智能设计的抗SARS-CoV-2刺突S2茎螺旋单克隆抗体（GB-0669）首次人体试验：随机、双盲、安慰剂对照试验
Francesco Borriello,Gavin C K W Koh,Iñaki F Troconiz et al.
Francesco Borriello et al.
Background: Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a half-life-extended monoclonal antibody optimized using artif...
Safety and Immunogenicity of a PD-1-Enhanced HIV-1 Therapeutic DNA Vaccine: A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Clinical Trial in People With HIV-1 on Antiretroviral Therapy [0.03%]
一种增强PD-1功能的HIV-1治疗型DNA疫苗的安全性和免疫原性：抗逆转录病毒疗法患者中的随机、双盲、安慰剂对照I期临床试验
Qiaoli Peng,Yik Chun Wong,Wing Yin Cheng et al.
Qiaoli Peng et al.
Background: Therapeutic vaccines represent a potential strategy for HIV-1 control without antiretroviral therapy (ART). We report a first-in-human study on ICVAX™, a PD-1-enhanced HIV-1 therapeutic DNA vaccine. ...