Does the Evidence Support High-Dose Liposomal Amphotericin B in the Treatment of Mucormycosis? [0.03%]
证据支持高剂量脂质体两性霉素B治疗黏菌病吗？
Russell E Lewis,Dimitrios P Kontoyiannis
Russell E Lewis
Guidelines recommend liposomal amphotericin B (L-AMB) at 5-10 mg/kg/day as first-line therapy for invasive mucormycosis, but whether doses exceeding 5-6 mg/kg/day improve outcomes enough to justify added nephrotoxicity and cost remains uncl...
Early transcriptional signature in chikungunya predicts chronic arthralgia and reveals deficient antiviral response [0.03%]
鸡库尼亚病早期转录标志预测慢性关节痛并揭示抗病毒反应缺陷
Thiago Cerqueira-Silva,Laise de Moraes,Blenda de Jesus Pereira et al.
Thiago Cerqueira-Silva et al.
Objective: Post-acute viral syndromes are increasingly recognised as causes of prolonged disability, with a notably higher prevalence in women. This study investigated the immune signature of individuals who progressed to...
Age- and Sex-Dependent Heterogeneity in Mumps Virus Immunity Among US Blood Donors Born Between 1928-1993 [0.03%]
美国1928至1993年间出生的血液捐赠者中风疹病毒免疫的年龄和性别异质性
Aum R Patel,Axel A Guzmán-Solís,Gregory A Foster et al.
Aum R Patel et al.
Background: Despite widespread vaccination, mumps outbreaks continue to occur, raising concerns about waning immunity and strain-specific differences in neutralizing antibody responses. ...
Reply to Akiyama and Berk: Response-Guided HCV Therapy and the Imperative to Treat in Carceral Settings [0.03%]
回应Akiyama和Berk对依从性指导的丙型肝炎治疗及其在羁押场所治疗紧迫性的评论
Kimberly Page,Ashish Goyal,Scott J Cotler et al.
Kimberly Page et al.
Shortening HCV Treatment in U.S. Jails: Opportunities and Implementation Considerations [0.03%]
美国监狱HCＶ治疗缩短：机会与实施考虑因素
Matthew J Akiyama,Justin Berk
Matthew J Akiyama
Sub-district spatial heterogeneity in trachoma seroprevalence as populations approach elimination [0.03%]
人群接近沙眼消除之际，各街道空间沙眼血清流行病学差异较大
Ariktha Srivathsan,Everlyn Kamau,Ambahun Chernet et al.
Ariktha Srivathsan et al.
Programmatic decisions regarding surveillance and intervention for trachoma are made at the district level, reflecting an implicit assumption that transmission within districts is sufficiently homogeneous. However, as transmission declines,...
Genetic Susceptibility to Periprosthetic Joint Infection in Total Knee Arthroplasty: Insights from Familial Analysis [0.03%]
人工膝关节置换术后假体周围关节感染的遗传易感性：来自家族分析的启示
Allan K Metz,Mackenzie Kelly,Michael J Jurynec et al.
Allan K Metz et al.
The susceptibility to periprosthetic joint infection (PJI) likely has a genetic component. However, the responsible genes are unknown. We performed whole-exome sequencing on four siblings, three of whom had undergone total knee arthroplasty...
Potential Risks and Benefits of Low-Barrier Access and Monitoring for HIV Preexposure Prophylaxis: A Modeling Study [0.03%]
低障碍暴露前预防用药获取和监管的潜在风险与获益：基于模型的研究
Adrien V Le Guillou,Julia L Marcus,Douglas S Krakower et al.
Adrien V Le Guillou et al.
Background: PrEP prevents HIV acquisition, but its population-level impact is limited by access barriers. Low-barrier delivery of daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC), such as over-the-counter ...
Neutralisation capacity against SARS-CoV-2 ancestral, Delta and Omicron variants before and after heterologous booster vaccination in Fijian health system workers [0.03%]
斐济卫生系统工作者异源加强免疫前后针对SARS-CoV-2原始株、德尔塔和奥密克戎变异株的中和能力
Anaseini Ratu,Isireli Rabukawaqa,Reuben McGregor et al.
Anaseini Ratu et al.
Immunogenicity studies of booster doses of COVID-19 vaccines from Pacific Island countries are limited. A prospective cohort study was conducted amongst healthcare workers in Fiji to assess antibody neutralisation capacity against ancestral...
Influenza Antibody Levels Associated with Laboratory-Confirmed Influenza in a Test-Negative Study Design, US Flu VE Network, November 2018-May 2019 [0.03%]
美国流感疫苗效应网络中确诊的实验室检测证实的流感抗体水平相关性，2018年11月-2019年5月 流感防护测试阴性的研究设计
Brendan Flannery,Jessie R Chung,Crystal Holiday et al.
Brendan Flannery et al.
Background: We assessed associations between antibody concentrations within 7 days of symptom onset and testing positive for influenza virus infection among outpatients enrolled in a test-negative study. ...