Weight Gain on Contemporary Integrase Strand Transfer Inhibitors and Tenofovir Alafenamide in Persons with HIV Starting Antiretroviral Therapy in the United States and Canada [0.03%]
美国和加拿大新启动抗逆转录病毒治疗的HIV感染者使用整合酶链转移抑制剂及阿夫雷夫沙韦引起的体重增加
Kassem Bourgi,Aihua Bian,Lakeisha Boyd et al.
Kassem Bourgi et al.
Background: Weight gain is common following antiretroviral therapy (ART) initiation. Integrase strand transfer inhibitors (INSTIs) and tenofovir alafenamide (TAF) have been associated with greater weight gain, though prio...
Switching to Daily Doravirine/Islatravir (100/0.25 mg) Maintains Viral Suppression Through Week 48 Despite Baseline Non-Nucleoside Reverse Transcriptase Inhibitor Resistance-Associated Mutations or M184I/V in Proviral DNA [0.03%]
尽管基线非核苷逆转录酶抑制剂耐药相关突变或携带M184I/V的原病毒DNA，每天一次doravirine/islatravir（100/0.25毫克）转换疗法仍能维持48周的病毒学抑制作用
Tracy L Diamond,Anjana Grandhi,Monica Fuszard et al.
Tracy L Diamond et al.
Background: Doravirine/islatravir (DOR/ISL) is a 2-drug, single-tablet regimen in clinical development for once-daily treatment of adults living with HIV-1. We examined the impact of baseline resistance-associated mutatio...
Distinct Plasmodium falciparum Erythrocyte Membrane Protein 1 Domain Cassette-Associated Antibody Gaps Specific to Cerebral Malaria and Severe Malarial Anemia [0.03%]
与脑型疟疾和重症疟疾贫血相关的特异性区别Plasmodium falciparum红细胞膜蛋白1结构域支架相关抗体缺口
Mark A Travassos,Paul Han,Drissa Coulibaly et al.
Mark A Travassos et al.
Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play an important role in host immune system evasion and parasite sequestration. The PfEMP1 antigenic domains that drive immune-mediated p...
Development of a Phase 1 Cryptosporidiosis Controlled Human Challenge Model in Healthy Volunteers Using Current Good Manufacturing Practice Cryptosporidium Parvum Oocysts and Conducted Under an Investigational New Drug Application [0.03%]
在健康志愿者中使用现行优良制造实践的隐孢子虫卵囊并根据调查新药申请开展一期隐孢子虫可控人体感染模型的开发研究
Bridget D Stuart,Kristen Stevenson,Hanns-Christian Tillmann et al.
Bridget D Stuart et al.
Background: Cryptosporidiosis is a leading cause of pediatric diarrhea in low-resource settings with limited treatment options. We established a controlled human infection model (CHIM) using current good manufacturing pra...
The Maxwell Finland Lecture 2025: Antimicrobial Resistance At The Bedside: Translating Science Into Patient Outcomes [0.03%]
2025芬兰麦克斯韦讲座：床旁抗菌素耐药性：将科学研究转化为改善患者的治疗效果
Cesar A Arias
Cesar A Arias
Antimicrobial resistance (AMR) is one of the most pressing public health threats of the 21st century. The development of resistance to antimicrobial agents is multifactorial. However, a major driver of AMR is the remarkable capacity of micr...
Vaccine Response Assessment in Children Using Dried Blood Spots: The DRIVE Study [0.03%]
儿童干血点检测疫苗反应评估：DRIVE研究
Paula Rodríguez-Molino,Ana Rodríguez Galet,Iker Falces-Romero et al.
Paula Rodríguez-Molino et al.
Background: Dried blood spots (DBS) are a minimally invasive alternative to serum for serological surveillance, but pediatric data remain limited, particularly in high-resource settings and in immunocompromised children. ...
Ubiquitination Defect of XIAP as Novel Susceptibility to Invasive Fungal Pneumonia [0.03%]
XIAP泛素化缺陷是侵袭性肺真菌病的新易感因素
Rachel Ying Min Tan,Zhi Xiong Chen,J Sivaraman et al.
Rachel Ying Min Tan et al.
Programmed cell death and systematic protein degradation as exemplified by apoptosis and ubiquitination respectively, are essential biological processes for homeostasis and cellular regeneration. We show that dysregulated ubiquitination and...
Impact of Low Community Circulation of Respiratory Syncytial Virus (RSV) on Immunity Debt against RSV in Adults During the COVID-19 Pandemic [0.03%]
新冠肺炎大流行期间社区呼吸道合胞病毒(RSV)低循环对成人RSV免疫债的影响
Vasanthi Avadhanula,Juan Bournat,Laura L Ferlic-Stark et al.
Vasanthi Avadhanula et al.
Introduction: The concept of immunity debt due to reduced circulation of RSV in adults is controversial. We questioned whether adults lost protective antibodies when RSV was not circulating in Houston during the SARS-CoV-...
Altered Diffusion Tensor Image Analysis Along the Perivascular Space in People Living with HIV: Association with Cognition and Diagnostic Utility for Asymptomatic Neurocognitive Impairment [0.03%]
沿血管周空间进行的扩散张量成像在HIV感染者中的改变：与认知及无症状神经损伤诊断价值的相关性
Ke Xue,YuXin Shi,Yinwen Gan et al.
Ke Xue et al.
Background: To investigate glymphatic function in people living with HIV (PLWH) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS), and explore its associations with cognition and clinical s...
PvGAP: Development of a globally-applicable, highly-multiplexed microhaplotype amplicon panel for Plasmodium vivax [0.03%]
PvGAP：开发出一种全球通用的、高度复性的恶性疟原虫微等位基因扩增片段测序面板
Alfred Hubbard,Edwin Solares,Lauren Bradley et al.
Alfred Hubbard et al.
Background: Plasmodium vivax malaria research has yet to fully benefit from the advances in genomic surveillance that have revolutionized P. falciparum epidemiology. Closing this gap is critical because genomic tools are ...