Genomic epidemiology of fluoroquinolone-resistant strains of Shigella sonnei and Shigella flexneri in the Iberian Peninsula from 2015 to 2022 [0.03%]
2015年至2022年伊比利亚半岛志贺菌宋内氏菌和福氏菌氟喹诺酮耐药株的基因组流行病学
Camille Jacqueline,Corrado Minetti,Sara Monzon Fernandez et al.
Camille Jacqueline et al.
Fluoroquinolone-resistance in Shigella is among the serious antimicrobial resistance (AMR) threats. We investigated the genomic epidemiology of fluoroquinolone resistant (FQR) strains of S. sonnei and S. flexneri from 2015 to 2022 in Spain ...
Rotavirus vaccine effectiveness stratified by national-level characteristics: an introduction to the 24-country MNSSTER-V Project, 2007-2023 [0.03%]
基于国家特征分层的轮状病毒疫苗效力：2007-2023年24国MNSSTER-V项目概述
Eleanor Burnett,Jazmina Umana,Palwasha Anwari et al.
Eleanor Burnett et al.
Background: Rotavirus vaccines are moderately protective against illness in high mortality settings compared with low mortality settings. Vaccine effectiveness (VE) evaluations may clarify our understanding of these dispa...
Asymptomatic and mildly symptomatic influenza virus infections by season --Case-ascertained household transmission studies, United States, 2017-2023 [0.03%]
美国2017—2023年流感病毒感染的季节性无症状和轻症感染——基于病例的家庭传播研究
Jessica E Biddle,Huong Q Nguyen,H Keipp Talbot et al.
Jessica E Biddle et al.
Asymptomatic influenza virus infection occurs but may vary by factors such as age, vaccination status, or season. We examined the frequency of influenza virus infection and symptoms using data from two case-ascertained household transmissio...
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure [0.03%]
碳青霉烯暴露后产ESBL大肠埃希菌ST131克隆株初始适应性的全面评估
William C Shropshire,Xinhao Song,Jordan Bremer et al.
William C Shropshire et al.
Background: It remains unclear how high-risk Escherichia coli lineages, like sequence type (ST) 131, initially adapt to carbapenem exposure in their progression to carbapenem resistance. ...
Effective real-time transmission estimations incorporating population viral load distributions amid SARS-CoV-2 variants and pre-existing immunity [0.03%]
有效结合人口病毒负荷分布的实时传输估计值 相关新冠肺炎变异毒株和既有免疫力的情形下
Yu Meng,Yun Lin,Weijia Xiong et al.
Yu Meng et al.
Background: Population-level viral load distribution, measured by cycle threshold (Ct), has been demonstrated to enable real-time estimation of Rt for SARS-CoV-2 ancestral strain. The generalizability of the framework und...
Case-Control Study of Cervicovaginal Beta-/Gamma-HPV Infection in Women with HIV and Its Relation with Incident Cervical Precancer [0.03%]
HIV女性β/γ型HPV感染与宫颈癌前病变关系的病例对照研究
Howard D Strickler,Mykhaylo Usyk,Isam-Eldin Eltoum et al.
Howard D Strickler et al.
We studied cervicovaginal β-/γ-human papillomavirus (HPV) and their relationship to cervical precancer in women with HIV (WWH); having previously reported strong positive associations of β-/γ-HPV with incident head and neck cancer in th...
A Phase 1b/2a Single Ascending Dose Study of a Half-life Extended RSV Neutralizing Antibody, Clesrovimab, in Healthy Preterm and Full-term Infants [0.03%]
一项评估长效RSV中和抗体clesrovimab在健康早产儿及足月婴儿中的单次递增剂量Ib/IIa期研究
Shabir A Madhi,Eric A F Simões,Armando Acevedo et al.
Shabir A Madhi et al.
Background: Clesrovimab is an investigational monoclonal antibody with an extended half-life targeting site IV of the respiratory syncytial virus (RSV) fusion protein for the prevention of RSV disease in infants. ...
Development of high titer anti-drug antibodies in a Phase 1b/2a infant clesrovimab trial are associated with RSV exposure beyond day 150 [0.03%]
一项婴儿clesrovimab一期b/二期a期试验中，接触RSV时间超过150天后产生高滴度抗药物抗体的发展情况
Nithya Thambi,Jia Yao Phuah,Ryan P Staupe et al.
Nithya Thambi et al.
Background: Clesrovimab is a human half-life extended mAb in phase 3 evaluation for the prevention of RSV disease in infants. ADA were observed at late time points in a phase 1b/2a study where clesrovimab was well tolerat...
Genomic analysis of global Mycobacterium abscessus isolates reveals ongoing evolution of drug-resistance-associated genes [0.03%]
基因组分析揭示了全球分枝杆菌脓肿亚种菌株中与耐药相关基因的持续进化
Tingting Yang,Kylie E Beach,Chendi Zhu et al.
Tingting Yang et al.
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5,617 clinical MAB isolates from 20 countries and searched fo...