Initiation of oral pre-exposure prophylaxis associated with changes in genital tract T cell phenotypes in women exposed to HIV [0.03%]
口服暴露前预防与HIV暴露女性生殖道T细胞表型变化的关系
Lakshmi Warrier,Ayumi Saito,Jessica B Graham et al.
Lakshmi Warrier et al.
Oral tenofovir-based HIV-pre-exposure prophylaxis (PrEP), approved for use in preventing human immunodeficiency virus (HIV) infection, has been implicated in altering the immune landscape. We leveraged longitudinal samples from heterosexual...
Regulatory T-cell Notch4 expression correlates with mortality in hospitalized COVID-19 patients [0.03%]
调节性T细胞Notch4表达与住院COVID-19患者的死亡率相关
Samer Alkarkoukly,Shadi Hambo,Mario Menk et al.
Samer Alkarkoukly et al.
Purpose: Severe COVID-19 is characterized by profound immune dysregulation, yet the mechanisms distinguishing fatal from non-fatal outcomes remain incompletely understood. Regulatory T (Treg) cells have been shown to play...
Plasma GDF-15 levels are associated with HIV reservoir markers independently of inflammation in people with HIV on antiretroviral therapy [0.03%]
HIV感染者接受抗逆转录病毒治疗后血浆GDF-15水平与HIV储存库标志物相关且独立于炎症标志物的影响
Stephane Isnard,Lena Royston,Carolina A Berini et al.
Stephane Isnard et al.
Background: People with HIV (PWH) receiving antiretroviral therapy (ART) have increased risks of non-AIDS comorbidities. Growth differentiation factor-15 (GDF-15) is a mitokine released upon mitochondrial stress, and a va...
Rapid HCV diagnostics: aligning molecular innovation with real-world elimination needs [0.03%]
快速诊断丙型肝炎：分子创新与现实世界消除需求的协调统一
Riham Soliman,Ayman A Hassan,Gamal Shiha
Riham Soliman
We comment on the recent study by Reed et al. describing the development of a rapid, automated point-of-care polymerase chain reaction (PCR) assay for hepatitis C virus (HCV) RNA on the DASH platform. This work represents an important step ...
Reply to Soliman et al, Rapid HCV diagnostics: aligning molecular innovation with real-world elimination needs [0.03%]
对Soliman等人的回复：快速丙型肝炎病毒诊断：使分子创新与现实世界的消除需求相适应
Jennifer L Reed,Matthew A Butzler,Claudia A Hawkins et al.
Jennifer L Reed et al.
Hidden Infections, Emerging Resistance: Underdiagnosed Plasmodium vivax and multidrug resistance-1 (pvmdr1) gene Amplification in the Guiana Shield [0.03%]
隐藏的感染与日益增长的耐药性：盖亚那屏障地区的间日疟原虫（恶性疟疾）的漏诊及多药抗性1（pvmdr1）基因扩增现象
Maria Carolina Silva de Barros Puça,Maria Eduarda Pereira Mascarenhas,Queralt Bullich Huguet et al.
Maria Carolina Silva de Barros Puça et al.
Background: Plasmodium vivax is the most widespread malaria parasite, and its co-circulation with Plasmodium falciparum often leads to underdiagnosis and underestimated transmission. We investigated whether underdiagnosis...
Risk factors and geospatial associations with Plasmodium falciparum malaria infection and IgG seroprevalence: Nigeria, 2018 [0.03%]
尼日利亚2018年恶性疟原虫感染和IgG血清阳性率的风险因素及空间分布特征
Alicia Jaramillo-Underwood,Abiodun Ogunniyi,Hong Zhou et al.
Alicia Jaramillo-Underwood et al.
Background: Nigeria consistently shows the greatest population burden of Plasmodium falciparum (Pf) malaria. While rapid diagnostic tests and microscopy offer valuable information for clinical decisions and prevalence est...
Safety, Pharmacokinetics, and Pharmacodynamics of Single-Dose Programmed Cell Death Protein 1 Inhibitor, Budigalimab, in People With HIV-1 With Antiretroviral Therapy-Suppressed Viral Load [0.03%]
抗HIV-1病毒载量的抗逆转录病毒疗法单剂量布地加利单抗程序性死亡蛋白1抑制剂的安全性、药代动力学和药效学研究
Tanaya R Vaidya,Till Geib,Jacob P Lalezari et al.
Tanaya R Vaidya et al.
Background: Blockade of inhibitory immune checkpoint receptor programmed cell death protein 1 (PD-1) on target immune cells is associated with improved HIV-specific immune function and activation of latent HIV. This rando...
Viral dynamics of the Respiratory Syncytial Virus during experimental human challenge: insights for transmission and protection [0.03%]
呼吸道合胞病毒人体感染实验中的病毒动态学：关于传播和预防的启示
Clarisse Schumer,Alex J Mann,Slim Fourati et al.
Clarisse Schumer et al.
Background: Respiratory syncytial virus (RSV) is a leading cause of respiratory infection. An in-depth quantification of its clinical, viral, and immune kinetics could provide further insights into tailoring interventions...
Distinct inflammatory programming of thoracic cavity white adipose immune cells regulates influenza pathogenesis [0.03%]
胸腔白色脂肪组织免疫细胞的炎症编程调节流感发病机制的独特作用
Cassidy J Ulanowicz,Pablo C Alarcon,Michelle S M A Damen et al.
Cassidy J Ulanowicz et al.
Background: Obesity-associated inflammation in white adipose tissue (WAT) worsens outcomes of influenza A virus (IAV) infection. A recently identified thoracic cavity WAT (tcWAT) supports IAV replication. However, tcWAT's...