Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity [0.03%]
连接蛋白32在氧化锌纳米颗粒诱导的肝毒性中的作用
Erting Wei,Leran Wu,Guofeng Xia et al.
Erting Wei et al.
The hepatotoxicity of zinc oxide nanoparticles（ZnO NPs) is of great concern. Connexin32 (Cx32), as a crucial mediator for various kinds of liver injuries, has little investigation on ZnO NPs-induced hepatotoxicity. In the present study, smal...
Malondialdehyde and Nitric Oxide Levels Reveal Comparative Toxicity of Three Insecticides in Wistar Rats [0.03%]
三种杀虫剂在Wistar大鼠体内毒性的MDA和NO水平指标的比较研究
Amit Singh Yadav
Amit Singh Yadav
Pesticides are metabolized in mammals by phase I reactions (through cytochrome P450) and phase II reactions. The parent molecule or its metabolites produced during phase-I reactions can be toxic, which are detoxified by phase-II reactions. ...
Renoprotective properties of resveratrol in the treatment of renal fibrosis, renal cell carcinoma, diabetic nephropathy and nephrotoxicity: a review of current evidence based on underlying cellular mechanisms [0.03%]
白藜素治疗肾纤维化、肾细胞癌、糖尿病肾病和肾毒性：基于潜在细胞机制的当前证据综述
Tareq Nayef AlRamadneh,Waleed K Abdulsahib,Sajida Hussein Ismael et al.
Tareq Nayef AlRamadneh et al.
Chronic kidney disease and its complications, including renal fibrosis, diabetic nephropathy, and renal cell carcinoma represent a major global health burden with limited therapeutic options. Resveratrol, a naturally occurring polyphenol fo...
Kai Wen Wai,Yin Quan Tang,Jhi Biau Foo et al.
Kai Wen Wai et al.
Foam cell formation is a critical pathological process that contributes significantly to the development of atherosclerosis, influenced by processes such as vascular senescence and autophagy-lysosomal pathways. The transcription factor nucl...
Unraveling nitrosamine-induced carcinogenesis: toxicological aspects and molecular insights [0.03%]
硝胺诱导致癌的毒理学及分子机制研究进展
Dipanjan Karati,Subhrojyoti Mukherjee,Somnath Das et al.
Dipanjan Karati et al.
Nitrosamines are a broad class of chemical compounds that are generally produced when amine congeners react with nitrosating substances, occasionally with nitrites present. Tobacco smoke, processed foods, certain medications, and industrial...
Dimensional differences between commercial asbestos and cleavage fragments of amphiboles: Classification approaches and implications for toxicological studies [0.03%]
商用石棉与角闪石解理碎片之间的尺寸差异：分类方法及其对毒理学研究的意义
Andrey A Korchevskiy,Ann G Wylie
Andrey A Korchevskiy
Asbestiform fibers and cleavage fragments of the same mineral have different origins, though distinguishing between samples of fibers and fragments is often complicated. This study aims to demonstrate an efficient method for distinguishing ...
Application of the C-BED tool in the analysis of the effect of norfluoxetine as an EDC on the marine mussel Mytilus trossulus [0.03%]
C-BED工具分析氟诺沙星作为环境内分泌干扰物对海湾贻贝(mytilus trossulus)的影响研究
Anna Hallmann,Paulina Goździk,Katarzyna Smolarz
Anna Hallmann
Norfluoxetine (NFLU), a metabolite of the antidepressant fluoxetine, is a known persistent endocrine-disrupting chemical (EDC) detected in aquatic environments. This study applies the Coastal Biosensor for Endocrine Disruption (C-BED) trans...
M3Hep: A Multimodal Hepatotoxicity Prediction Model Combining Mitochondrial Toxicity and Masking Strategy [0.03%]
M3Hep：一种结合线粒体毒性和掩膜策略的多模态肝毒性预测模型
Yang Liu,Yu Xie,Xiao Wang et al.
Yang Liu et al.
Drug hepatotoxicity is one of the primary reasons for drug clinical trial failures and market withdrawals, with mitochondrial dysfunction being one of the mechanisms inducing drug hepatotoxicity. Manifestation of mitochondrial toxicity occu...
6-pentadecyl salicylic acid reduces cell proliferation in U373MG glioblastoma cells via glutamine uptake impairment [0.03%]
6-十五烷基水杨酸通过抑制谷氨酰胺摄取来减少U373MG胶质母细胞瘤细胞增殖
Laura I Méndez,Andrea Ocharán-Mercado,Luisa C Hernández-Kelly et al.
Laura I Méndez et al.
Glioblastoma cells exhibit a pronounced dependence on glutamine uptake, primarily via the alanine‑serine‑cysteine transporter 2, since its deletion prevents glioma growth, making this transporter an attractive therapeutic target. This stu...
Axis-based propagation of nanoplastic toxicity: Organ-organ crosstalk and systemic pathophysiological outcomes [0.03%]
基于轴心的纳米塑料毒性传播：器官-器官相互作用和全身病理生理结果
Sijoon Lee
Sijoon Lee
Nanoplastics (NPs) are emerging as environmental pollutants with the capacity to penetrate biological barriers, distribute systemically, and cause toxicity to multiple organs. Although early studies have primarily focused on localized organ...