Acute and subchronic oral toxicity study, phytochemical profiling of a herbal formulation containing Taxus, astragalus, asparagus, and liquorice in mice [0.03%]
含唐松草、黄芪、白术和甘草的复方制剂的急性及亚慢性口服毒性研究以及植物化学成分分析
Muhammad Yousif,Samuel Kumi Okyere,Dongqiong Xiao et al.
Muhammad Yousif et al.
Zishangan Granule (ZSG) is a plant-derived formulation containing Taxus, Astragalus, Asparagus, and licorice. Its phytochemical composition and oral toxicological safety remain insufficiently characterized. This study profiled ZSG constitue...
Advances in Artificial Intelligence and Machine Learning for Toxicity Prediction in Computational Toxicology: A Comprehensive Review [0.03%]
计算毒理学中的毒性预测的人工智能和机器学习进展：全面综述
Gerald Shija
Gerald Shija
Over the past three decades, artificial intelligence (AI) and machine learning (ML) have revolutionized computational toxicology, providing powerful tools for predicting chemical toxicity and supporting safer assessments for human health an...
A study on the influence of environmental toxicants on the luminol/KSCN/H2O2/Cu oscillator [0.03%]
环境毒物对鲁米诺-KSCN-H2O2-Cu化学振子的影响研究
F Gagné,C André
F Gagné
Oscillatory reactions involving periodical oxido-reduction reactions are commonly found in life-sustaining processes. The purpose of this study consisted in using the luminol-KSCN-H2O2-Cu(II) oscillator to probe the capacity of known enviro...
Perspective for breaching the positive feedback loop between necroptosis and pyroptosis with spirulina in alcoholic liver injury induced in mice [0.03%]
螺旋藻通过打断酿酒酵母诱导的小鼠酒精性肝损伤中坏死性和焦亡性的正反馈回路的可能性研究观点
Ghada S El-Tanbouly
Ghada S El-Tanbouly
The functional nutraceutical Spirulina (SP) was evaluated against alcohol intoxication in mice livers, concurrently striving to elucidate its protective mechanisms in cellular death pathways: necroptosis and pyroptosis. Ethanol (ET) intoxic...
Combined Molecular Fingerprint and Descriptor Features Enable Classical Machine Learning to Match Deep Learning Performance Across the Tox21 Toxicity Panel [0.03%]
结合分子指纹和描述符特征使经典机器学习在Tox21毒性谱系上的性能可与深度学习相媲美
Oluwaseun E Agboola,Samuel S Agboola,Adekunle T Adegbuyi et al.
Oluwaseun E Agboola et al.
Background and objective: Molecular fingerprints and physicochemical descriptors encode complementary structural information, yet most Tox21 benchmarks evaluate only one representation at a time. This study examined wheth...
Computational Toxicology Prioritization of CYP3A4 and DPP7 as Candidate Triclosan-Relevant Molecular Targets in Ulcerative Colitis [0.03%]
计算毒理学筛选优先考虑UC中三氯生相关分子靶标CYP3A4和DPP7
Jiafeng Wang,Songsong Jiang,Yingying Zhang et al.
Jiafeng Wang et al.
Triclosan (TCS), a synthetic broad-spectrum antimicrobial classified as a novel persistent organic pollutant, is detected in over 75% of human urine samples, yet its molecular targets in ulcerative colitis (UC) remain uncharacterized at a s...
Systemic histopathological responses to nanoplastic exposure: A review of cellular toxicity and organ-level pathology in mammalian systems [0.03%]
纳米塑料暴露引起的系统性组织病理学反应：哺乳动物细胞毒性与器官水平病理学的综述研究
Sijoon Lee
Sijoon Lee
Nanoplastics (NPs), a subfraction of microplastics smaller than 1 μm, are increasingly recognized for their ability to cross biological barriers and induce organ-level toxicity; however, their systemic histopathological effects remain frag...
Reclassification of the main impurity (-)-scopolamine hydrobromide trihydrate in scopolamine butylbromide: an integrated ICH M7 guideline assessment combining in silico, in vitro, and in vivo studies [0.03%]
氢溴酸鼻甲胆碱中的主要杂质(-)氢溴酸斯可 па л胺三 hydrate 的重新分类：结合体内和体外研究的ICH M7指南评估
Rui Li,Su Zhou,Hongyan Zhu et al.
Rui Li et al.
Following the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) multidisciplinary guideline M7 (R2), in silico prediction, in vitro and in vivo genotoxicity evaluations were used to ev...
Quercetin attenuates vancomycin-induced acute hepatotoxicity in rats through modulation of Nrf2 and NF-κB related oxidative stress and inflammatory signaling pathways [0.03%]
檞皮素通过调节Nrf2和NF-κB相关氧化应激和炎症信号通路缓解万古霉素致大鼠急性肝毒性
Gokhan Akcakavak,Ozhan Karatas,Filiz Kazak Akcakavak et al.
Gokhan Akcakavak et al.
Vancomycin (VM) therapy is one of the cornerstone options in the treatment of resistant Gram-positive bacterial infections. However, its drawback is associated with the side effect hepatotoxicity during optimal high doses. It is unknown whe...
Toxic Effects of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) on the Gut Microenvironment and Their Potential Association with Colorectal Cancer [0.03%]
全氟和多氟化合物(PFAS)对肠道微环境的毒性作用及其与结直肠癌发病潜在关联性研究
Xiufen Tang,Lixin Tang
Xiufen Tang
Per- and polyfluoroalkyl substances (PFAS) are persistent surfactants with ingestion as a major exposure route, positioning the intestine as a primary site of contact. This narrative review integrates mechanistic toxicology, multi-omics mic...