Polystyrene Nanoplastics Induce Pyroptosis in HepG2 Cells via the YAP1-cGAS-STING Signaling Axis [0.03%]
聚苯乙烯纳米塑料通过YAP1-cGAS-STING信号轴诱导HepG2细胞焦亡
Yong Yang,Zuodong Liu,Mao Cao et al.
Yong Yang et al.
Background: Polystyrene nanoplastics (PS-NPs) are emerging environmental contaminants with documented hepatotoxic potential, yet the mechanisms underlying their liver toxicity remain incompletely understood. ...
Investigation of the underlying mechanism of rifampicin-induced hepatotoxicity and neurotoxicity in mice by untargeted metabolomics and gut microbiota approach [0.03%]
基于未靶标代谢组及肠道微生物的研究rifampicin致小鼠肝毒性与神经毒性的机制探讨
Jiuli Yuan,Lina Tao,Yanjiao Li et al.
Jiuli Yuan et al.
Rifampicin (RIF) remains a first-line antituberculosis agent. However, its usefulness is limited by its hepatotoxicity and potential neurotoxicity. The aim of this study was to investigate the association between dysbiosis of gut microbiota...
Lauric acid attenuates hepatic lipid metabolism by modulating the AMPK-SREBP pathway in high-fat diet-induced obese mice [0.03%]
月桂酸通过调节AMPK-SREBP信号通路改善高脂饮食小鼠肝脂代谢
Chi Hau Wong,Lai Yen Fong,Tengku-Sifzizul Tengku-Muhammad et al.
Chi Hau Wong et al.
Insulin resistance, characterized by a diminished cellular response to insulin signaling, is a central hallmark of metabolic disorders such as obesity and type 2 diabetes mellitus. This impaired responsiveness disrupts glucose and lipid hom...
Introducing AutoML framework for Drug-Drug Interaction Prediction: Application of AutoGluon [0.03%]
基于AutoGluon的药物相互作用预测自动化框架的研究与应用
Abdallah Abou Hajal,Molham Sakkal
Abdallah Abou Hajal
Drug-drug interactions (DDIs) remain a major concern in medication safety. Although advanced artificial intelligence methods such as deep learning have improved DDI prediction, their adoption is limited by the need for specialized expertise...
Novel insights into the mechanism of formaldehyde-induced lung cancer: a network toxicology and molecular docking approach [0.03%]
甲醛致肺癌作用机制的网络毒理学与分子对接研究获得新见解
Yizhe Wei,Yiming Zhao,Yanan Mi et al.
Yizhe Wei et al.
We explored the complex effects of formaldehyde (FA) on lung cancer through network toxicology and molecular docking techniques, focusing on understanding the molecular mechanisms by which FA affects lung cancer from a biological network pe...
Development of a semi-automated brightfield, high-content imaging approach for quantifying morphological effects in zebrafish embryos [0.03%]
斑马鱼胚胎形态学影响量化半自动显微镜高内涵图像分析方法的建立
Greta Nilén,Abir Ounoughi,Stefan Scholz et al.
Greta Nilén et al.
Environmental pollutants often induce morphological alterations in developing organisms, yet assessments are commonly subjective, limiting reproducibility and sensitivity. We developed and validated a semi-automated brightfield high-content...
Safety and efficacy of a novel phytoceutical formulation CL18100F4 in increasing gut motility and improving stool consistency in animals [0.03%]
新型植物药用配方CL18100F4改善动物胃肠运动和粪便性状的安全性和有效性
Tirupathi Rao Annavarapu,Shamshu Thabrez Shaik,Somepalli Venkateswarlu et al.
Tirupathi Rao Annavarapu et al.
Constipation and gastrointestinal (GI) dysmotility are prevalent disorders often associated with impaired gut-brain axis regulation and limited therapeutic options. This study investigated the safety and gastrokinetic efficacy of CL18100F4 ...
Mercury Chloride Exposure Induces Inflammatory and Functional Disruptions in Neurohepatic Physiology [0.03%]
氯化汞暴露引起神经肝生理的炎症和功能紊乱
Afridi Shaikh,Nancy Rana,Ayushi Gupta et al.
Afridi Shaikh et al.
Mercury (Hg) remains a prominent global contaminant despite regulatory interventions such as the Minamata Convention. Inorganic mercury (Hg2+), particularly mercuric chloride (HgCl2), persists in aquatic ecosystems and poses significant ris...
Integrative in silico-in vivo modeling identifies apigenin modulation of TGF-β1/SMAD2 in methotrexate-induced cardiotoxicity [0.03%]
整合的基于计算机和实验的研究发现植物提取物apigenin可通过调控TGF-β1/SMAD2信号通路缓解甲氨蝶呤引起的心脏毒性
Sawsan A Zaitone,Rehab M Lashine,Lamiaa M Elabbasy et al.
Sawsan A Zaitone et al.
Methotrexate (METX) is a widely used chemotherapeutic and immunosuppressive agent, frequently employed as a first-line treatment for various malignancies and autoimmune disorders. Despite its clinical efficacy, METX is known to induce cardi...
Mechanistic insights into Moringa oleifera leaf bioactive against cytotoxic stress: an integrative approach [0.03%]
卡氏芽孢杆菌生物活性叶对细胞毒性应激的机制见解：一种集成方法
Vivianna James Richards,Ryan Mathew Rowland,Lekha Priya Thilipkumar et al.
Vivianna James Richards et al.
Exposure to ionizing radiation during medical diagnostics and cancer therapy often results in collateral damage to healthy cells, primarily due to the generation of free radicals. Moringa oleifera (MO), known for its rich antioxidant profil...