Integrating NHANES and network toxicology to assess the impact of organophosphate flame retardants on cardiovascular disease [0.03%]
结合NHANES和网络毒理学评估磷酸酯类阻燃剂对心血管疾病的影响
Kai Dai,Yinglan Huang,Huaxiu Cai et al.
Kai Dai et al.
Cardiovascular disease (CVD) pathogenesis involves multifactorial determinants, including environmental pollutants. This study integrated National Health and Nutrition Examination Survey (NHANES) data and network toxicology approaches to in...
Is GDF15 or PGC-1α involved in 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced wasting syndrome? Evidence from a TCDD-sensitive and a TCDD-resistant rat strain [0.03%]
GDF15或PGC-1α在二噁英致恶病质综合征中的作用：来自二噁英敏感品系和耐受品系的证据
Raimo Pohjanvirta,Janne Hakanen,Sanna-Mari Aatsinki et al.
Raimo Pohjanvirta et al.
A drastic body weight loss, the wasting syndrome, is a hallmark of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), but its mechanism is still elusive. The present study sought to find out whether the growth differentiation...
Toxicological perspectives on potential mixture toxicity of alpha-hexylcinnamaldehyde and lilial in consumer products [0.03%]
消费者产品中香料成分己基肉桂醛和戊基肉桂醛混合毒性的毒理学观点研究
Kennlee Orola,Sung-Hwan Moon,Seung Hee Shin et al.
Kennlee Orola et al.
Alpha-hexylcinnamaldehyde (HCA) and 3-(4-tert-butylphenyl)-2-methylpropanal (Lilial) are widely used synthetic fragrance aldehydes found in personal care and household products. Individually, HCA is primarily recognized as a weak skin sensi...
The multifaceted effects of rosmarinic acid on breast cancer, regulating autophagy and increasing apoptosis [0.03%]
鼠李茋酸对乳腺癌的多重影响、调节自噬和增加细胞凋亡
Deniz Erol Kutucu,Merve Erkisa Genel,Ayca Uvez et al.
Deniz Erol Kutucu et al.
Cancer remains a complex and formidable disease that necessitates the development of diverse therapeutic strategies, including the investigation of natural products as complementary agents. Rosmarinic acid (RA), a phenolic compound, has dem...
Establishment of a strategy using alternative methods to the use of animals to evaluate the ocular irritant potential of cosmetics for styling, braiding, or fixing hair [0.03%]
建立替代动物试验方法评估用于盘发、编发或固定头发化妆品的眼刺激性的策略
Luciana Madureira de Araujo Lowndes Vieira,Renata Norbert Costa Nundes,Ronald Santos Silva et al.
Luciana Madureira de Araujo Lowndes Vieira et al.
Assessing the safety of cosmetic products requires rigorous analysis before marketing, with emphasis on the potential for ocular irritation, given the sensitivity of the eye and the complexity of the toxicological mechanisms involved. Ocula...
Nrf2 attenuates diquat-induced renal ferroptosis by regulating mitochondrial ferritin [0.03%]
Nrf2通过调节线粒体铁蛋白来减弱二喹啉诱导的肾脏铁死亡作用
Ziyi Wang,Meiyi He,Jifeng Dai et al.
Ziyi Wang et al.
This study investigated the protective effect of nuclear factor erythroid 2-related factor 2 (Nrf2) against diquat-induced acute kidney injury (AKI) by regulating mitochondrial ferritin (FtMt). A model of kidney injury was established in ...
Comparative screening of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity using spectroscopic and electrometric techniques [0.03%]
基于光谱法和电极法的乙酰胆碱酯酶和丁酰胆碱酯酶活性的筛选及其比较研究
Bruna Francisquete Costa,Vitoria Hioko da Silva Nakamura,Leticia Bortolini Machado et al.
Bruna Francisquete Costa et al.
Human blood acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are useful markers to assess the effects of pesticides exposure and the potential of compounds involved in the treatment of Alzheimer disease. Therefore, there is cruc...
Syringic acid exhibits ameliorative effects against cyclosporine A-induced cardiotoxicity in mice by mitigating oxidative stress, inflammatory response, and apoptotic cell death [0.03%]
丁香酸通过减轻氧化应激、炎症反应和细胞凋亡来改善环孢素A诱导的小鼠心毒性作用
Susan Sabbagh,Hassan Abbaszadeh,Parisa Beigi
Susan Sabbagh
Cyclosporine A (CsA) is a commonly used drug to inhibit graft rejection and treat a variety of autoimmune diseases. Cardiotoxicity is one of the most serious undesirable effects of CsA which has limited its clinical use. Syringic acid (SA) ...
Comparative Analysis of Methamphetamine's Metabolic Effects on Blood-Brain Barrier Endothelial Cells: An In Vitro Recreational versus Addictive Simulation [0.03%]
甲基苯丙胺代谢对血脑屏障内皮细胞影响的比较分析——体外娱乐与成瘾剂量模拟
Kelly Fick,David Fisher,Khayelihle Brian Makhathini et al.
Kelly Fick et al.
Methamphetamine (Meth) neurotoxicity has traditionally been attributed to monoaminergic disruption, yet growing evidence implicates early injury at the blood-brain barrier (BBB). The brain microvascular endothelial cells (BMVECs), which are...
Inhibitory Effects of 2-Hydroxyethyl methacrylate on IL-1β-Induced NF-κB Activation and Chemokine Production in Human Gingival Fibroblasts [0.03%]
2-羟乙基甲基丙烯酸酯对IL-1β诱导的人牙龈成纤维细胞NF-κB活化和趋化因子产生的抑制作用
Risa Okamoto,Yoshitaka Hosokawa,Ikuko Hosokawa et al.
Risa Okamoto et al.
2-Hydroxyethyl methacrylate (HEMA) is the most abundantly released monomer from dental restorative materials, and it has been suggested that it may also affect periodontal tissue cells. This study aimed to clarify the influence of HEMA on g...