Phytohemagglutinin-Induced NF-κB/MAPK Activation Stimulates a Broad Immune Checkpoint-Positive T Cell Model [0.03%]
植物凝集素诱导的NF-κB / MAPK活化刺激免疫检查点阳性T细胞模型
Kewei Qin,Huinan Zhou,Qi Chen et al.
Kewei Qin et al.
Jurkat cells serve as alternative cellular models to costly transgenic mice for immune checkpoint antagonist toxicology studies but require activation to express immune checkpoints. Although phytohemagglutinin (PHA) activates Jurkat cells a...
Correction [0.03%]
改正
Published Erratum
Toxicology mechanisms and methods. 2026 Mar 24:1. DOI:10.1080/15376516.2026.2640656 2026
Real-time monitoring of microplastic accumulation in fish bodies using transparent goldfish revealed initial attack on the gill [0.03%]
利用透明金鱼实时监测鱼类体内微塑料积累发现鳃部最先受攻击
Md Abul Bashar,Saokat Ahamed,Takumi Mouri et al.
Md Abul Bashar et al.
To investigate the adverse effects of microplastics (MPs), we conducted an analysis using transparent goldfish (Carassius auratus). Transparent young goldfish were exposed to chronic toxicity concentration of fluorescently labeled microplas...
ROS-activated oral enterosorbent nanogel to block gastrointestinal absorption of lead and cadmium: an in vitro study [0.03%]
ROS激活的口服肠道吸附纳米凝胶阻断铅和镉胃肠吸收的体外研究
Nashat Abdalaty
Nashat Abdalaty
Occupational ingestion of metal-laden dust in quarry and mining environments contributes significantly to chronic exposure to lead (Pb) and cadmium (Cd). In the present study, we developed a non-systemic oral enterosorbent nanogel incorpora...
Computational toxicology of N-nitrosamine impurities: from molecular structure to regulatory concern [0.03%]
硝胺杂质的计算毒理学：从分子结构到监管关注点
Rupal Kushwah,Madhavi Kumari,Prabha Garg
Rupal Kushwah
Since 2018, drug recalls and other regulatory actions related to impurities, particularly N-nitrosamines, have raised significant toxicological and public health concerns. These potent carcinogens, characterized by the R2N-N = O moiety, may...
Arsenic-Cadmium Co-exposure Rewires Lipid-Iron Homeostasis to Drive Ferroptosis in Human Proximal Tubular Cells [0.03%]
砷和镉共暴露重塑脂质和铁稳态以驱动人类近端小管细胞铁死亡
Yongguo Liu,Dengke Liu,Chengrong Zhang et al.
Yongguo Liu et al.
Arsenic (As) and cadmium (Cd) frequently co-occur in groundwater and target renal proximal tubules. Although each metal can engage ferroptosis pathways, how co-exposure shapes the integrated transcript-protein-lipid ROS axis remains unclear...
Interpretable multi-modality consensus QSAR framework: integrating machine and deep learning for enhanced multi-endpoint toxicity assessment [0.03%]
可解释的多模态共识QSAR框架：结合机器和深度学习以增强多终点毒性评估
Fauzan Syarif Nursyafi,Muhammad Adnan Pramudito,Yunendah Nur Fuadah et al.
Fauzan Syarif Nursyafi et al.
Accurate toxicity assessment is essential for chemical safety, but experimental testing is costly, slow, and ethically constrained, motivating the adoption of computational approaches such as quantitative structure-activity relationship (QS...
Cisplatin-associated transcriptional changes in ER stress-related genes in skeletal muscle and C2C12 myotubes [0.03%]
顺铂致骨骼肌及C2C12肌管细胞内 unfolded protein response 相关基因表达变化的研究
Hayato Nanri,Hiroyasu Sakai,Shinki Soga et al.
Hayato Nanri et al.
Cisplatin is a widely used chemotherapeutic drug that causes severe side effects, including skeletal muscle atrophy; however, the cellular responses of skeletal muscle to cisplatin exposure remain incompletely characterized. This study aime...
Effects of cyclophosphamide on the metabolism of primary mouse hepatocytes [0.03%]
环磷酰胺对小鼠原代肝细胞代谢的影响
Yuanyuan Li,Jinrui Shi,Wen Ju et al.
Yuanyuan Li et al.
Cyclophosphamide (CTX) is limited by hepatotoxicity, whose underlying mechanism remains obscure. Since the liver is the central organ for metabolism, we thereby aimed to investigate the effect of CTX on the metabolism of the primary mouse h...
Raptors as Sentinels: Unveiling the Environmental and Health Risks of Pfas Contamination [0.03%]
RAPTORs作为哨兵：揭示PFAS污染的环境和健康风险
Giovanna Liguori,Fabio Castagna,Roberto Bava et al.
Giovanna Liguori et al.
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants of global concern due to their bioaccumulative and toxic properties. Raptors, as apex predators, are valuable sentinel species for monitoring PFAS contamin...