Ertugliflozin ameliorates thioacetamide-induced renal injury by modulating Nrf2-mediated oxidative stress, TLR4/STAT3 inflammatory signaling, and YAP/TAZ fibrotic pathways [0.03%]
依格列净通过调节Nrf2介导的氧化应激、TLR4/STAT3炎症信号通路和YAP/TAZ纤维化途径改善硫代乙酰胺诱导的肾损伤
Naif ALSuhaymi,Mahdi H Alsugoor,Passant E Moustafa et al.
Naif ALSuhaymi et al.
Kidney damage, often caused by oxidative stress and inflammation, can lead to renal failure. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, including Ertugliflozin (Ertu), demonstrate renoprotective effects that may extend beyond glucos...
Title: Cosmetic preservatives: physicochemical descriptors, mechanistic toxicity, and methodological approaches [0.03%]
化妆品防腐剂的物理化学特性、毒性机理及方法研究
Wiktoria Omachel,Patrycja Pietruszewska,Anna Barbasz
Wiktoria Omachel
Cosmetic preservatives are widely used to ensure microbiological stability, yet their health risk assessment requires an understanding of dermal penetration mechanisms, interactions with the skin barrier, and cellular responses. This review...
E-cigarette aerosols as systemic metabolic disruptors: integrated mitochondrial, circadian, and neurobehavioral mechanisms [0.03%]
电子烟气溶胶会扰乱人体新陈代谢吗？综合评价线粒体、生物钟和神经行为机制的影响
Ardie Barry Sailis
Ardie Barry Sailis
E-cigarettes are promoted as reduced-harm alternatives to combustible tobacco, yet their aerosols contain metals, aldehydes, solvents, and other bioactive chemicals capable of disrupting metabolic regulation. This review synthesizes evidenc...
Glioprotective effects of gM-CSF against glutamate-induced oxidative stress, genotoxicity, and inflammation in rat C6 cells [0.03%]
粒细胞巨噬细胞集落刺激因子的胶质保护作用及其对谷氨酸诱导的大鼠C6胶质瘤细胞氧化应激、遗传毒性和炎症的影响
Farzaneh Motafeghi,Ehsan Ghassemi Barghi,Jafar Gholami Gharab et al.
Farzaneh Motafeghi et al.
Background: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is primarily known for hematopoiesis but has recently shown potential neuroprotective properties. This study investigated the glioprotective mechanisms...
3-Formylchromone attenuates urethane-induced lung carcinogenesis and enhances gefitinib anti-tumor response via modulation of IL-6/JAK1/STAT3/cyclin D1 signaling [0.03%]
3-甲醛香豆素通过调节IL-6 / JAK1 / STAT3 / cyclin D1信号传导减弱异氰脲酸引起的肺癌发生并增强吉非替尼的抗肿瘤反应
Amany A Azouz,Ahmed Khalaf,Rasha Hussein et al.
Amany A Azouz et al.
Lung cancer is the primary cause of cancer-related mortality globally. The reduced sensitivity to tyrosine kinase inhibitors (TKIs) upon prolonged treatment necessitates the search for effective modalities to improve the management of lung ...
Acrylamide-induced nephrotoxicity mediated through endoplasmic reticulum stress pathway in rat kidney: protective effect of 4-phenylbutyric acid [0.03%]
4-苯基丁酸对丙烯酰胺所致大鼠肾脏内质网应激介导的肾毒性的保护作用
Mohammed Nazish Quasmi,Dinesh Dhingra,Ashok Jangra
Mohammed Nazish Quasmi
The current study aims to explore the role of endoplasmic reticulum stress (ER stress) in acrylamide (ACR)-induced nephrotoxicity. In addition, the role of ER stress is pharmacologically validated by a chemical chaperone, 4-phenylbutyric ac...
Combined exposure effects and potential mechanisms of volatile organic compounds on liver fibrosis in the US population: an integrative epidemiological and computational toxicology analysis [0.03%]
美国人群挥发性有机化合物联合作用对肝纤维化的效应及潜在机制：整合流行病学和计算毒理学分析
Yinhang Cui,Xiaoyi Yan,Xiaocong Ma et al.
Yinhang Cui et al.
Background: Volatile organic compounds (VOCs) are widespread environmental pollutants that can cause oxidative stress and hepatocellular damage. However, epidemiological evidence linking VOC exposure to liver fibrosis and...
Comparative stability assessment of synthetic cannabinoids in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications [0.03%]
用于法医应用的干燥血点和血液中合成大麻素比较稳定性评估：UHPLC-MS/MS测定意义
Kaja Tusiewicz,Paweł Szpot,Marcin Zawadzki
Kaja Tusiewicz
Objectives: Synthetic cannabinoids are the most numerous group of new psychoactive substances (NPSs) in Europe. The diversity and quantity of newly emerging synthetic cannabinoids make it difficult to monitor intoxication...
Quercetin attenuates ox-LDL-induced endothelial injury by regulating ferroptosis via the SIRT3/AMPK signaling pathway [0.03%]
檞皮素通过SIRT3/AMPK信号通路调节铁死亡来缓解氧化型低密度脂蛋白诱导的内皮损伤
Chenglong Gao,Bin Liu,Rui Zhang et al.
Chenglong Gao et al.
This study investigated whether quercetin protects endothelial cells from Oxidized Low-Density Lipoprotein (Ox-LDL)-induced injury by inhibiting ferroptosis via the sirtuin 3 (SIRT3)/AMP-activated protein kinase (AMPK) signaling pathway. Hu...
Repurposing of piracetam to alleviate doxorubicin-induced cardiotoxicity in rats: Targeting TLR2/MyD88/AP-1/NF-κB and VEGF/eNOS signaling pathways [0.03%]
吡拉西坦再利用以缓解多柔比星致大鼠心脏毒性：靶向TLR2/MyD88/AP-1/NF-κB和VEGF/eNOS信号通路
Marwa Monier Mahmoud Refaie,Rehab Ahmed Rifaai,Asmaa A Hasan et al.
Marwa Monier Mahmoud Refaie et al.
Doxorubicin (DOXO) is a highly efficient antineoplastic agent, but its clinical usefulness faces major cardiotoxic hazards. Thus, current study aimed to investigate the novel potential ameliorative effect of piracetam (PIRA) against DOXO-in...