Copper-based nanoparticles-associated neurotoxicity: ions or particles? [0.03%]
铜基纳米粒子相关的神经毒性：离子还是颗粒？
Zehra Keskin,Can Özgür Yalçın,Engin Yenilmez et al.
Zehra Keskin et al.
The widespread use of engineered nanomaterials raises concerns regarding their potential toxicity to human health and the environment. Among metal oxide nanoparticles, copper-based nanoparticles (Cu-based NPs) are extensively produced and u...
Tobacco-Specific Nitrosamine "4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)": Toxicological Mechanisms, Carcinogenicity, and Chemopreventive Approaches [0.03%]
烟草特有亚硝胺“4-（甲基亚硝氨基）-1-（3-哒嗪基）-1-丁酮（NNK）”的毒理机制、致癌性及化学预防措施
Divya Kumari,Pracheta Janmeda,Devendra Singh
Divya Kumari
The tobacco-specific nitrosamine, 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone has been identified as potent lung carcinogen in laboratory animals. Bioactivation of nicotine-derived nitrosamine ketone occurs via cytochrome P450-mediated ...
Characterization of unusual Immunoassay Cross-Reactive Cannabinoid Metabolites in Canine Urine via Gas Chromatography-Mass Spectrometry [0.03%]
使用气相色谱-质谱法表征犬尿中不寻常的免疫测定交叉反应大麻素代谢物
Chris Pickard,John P Buchweitz,Andreas F Lehner
Chris Pickard
Recent increases in cannabis use and dog ownership have elevated the risk of canine cannabis intoxication, prompting a need for efficient diagnostic tools. Enzyme immunoassays (EIAs) that employ monoclonal antibodies specific to 11-nor-9-ca...
Acute oral toxicity evaluation of microencapsulated semi-purified fibrinolytic proteases using a modified OECD 423-aligned design for biotechnological applications [0.03%]
微囊半纯纤溶酶急性口服毒性评价——一种适用于生物技术应用的OECD 423方案改良设计
Ragil Saptaningtyas,Sri Rejeki,Ana Hidayati Mukaromah et al.
Ragil Saptaningtyas et al.
The present study evaluated the acute oral toxicity profile of microencapsulated semi-purified fibrinolytic proteases derived from Bacillus tequilensis HSFI-5 (Indonesian Patent Application No. S00202313485) using a modified OECD Guideline ...
Sandeepa K N,Shilpa S Shetty
Sandeepa K N
Fibrosis is essentially a compromised wound-healing process in which fibroblasts remain engaged for an extended period of time, resulting in an excessive accumulation of extracellular matrix and ultimately leading to organ failure. Although...
Beatriz Corrêa da Rocha,Marcos Trindade da Rosa Rosa,João Batista Teixeira da Rocha et al.
Beatriz Corrêa da Rocha et al.
We developed and validated a microvolume protocol for measuring catalase (CAT) activity using a NanoDrop spectrophotometer, enabling reliable quantification with as little as 2 µL of sample. This methodology provides an efficient alternati...
Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats [0.03%]
edaravone对纳米塑料诱导的大鼠内质网应激的肾脏保护作用研究
Rachna Yadav,Ashok Jangra,Dinesh Dhingra et al.
Rachna Yadav et al.
Background: Plastics in particular nanoplastics pose the major environmental threat worldwide. Nanoplastics refers to smaller plastic components with size less than 100 nm. Previous studies indicated that plastics could a...
From exposure to injury: signaling mechanisms of microplastic-induced renal toxicity: an extensive review [0.03%]
从暴露到损伤：微塑料致肾毒性的信号机制：综述性文章
Ankit Verma,Manju Sharma,Renu Kaushik et al.
Ankit Verma et al.
Environmental micro and nanoplastics (MNPs) have emerged as pervasive contaminants with growing implications for systemic toxicity and organ-specific pathophysiological outcomes. Among vulnerable organs, the kidney represents a critical tar...
Neurotoxic and Metabolic Effects of Chronic Aspartame Consumption in Rodent Models: A Systematic Review and Meta-Analysis [0.03%]
慢性阿斯巴甜摄入对动物模型的神经毒性和代谢影响的系统评价和meta分析
Arbind Kumar Choudhary,Nishant Singh
Arbind Kumar Choudhary
Aspartame (ASP), a widely used artificial sweetener, remains the subject of scientific scrutiny regarding its long-term safety. While regulatory agencies assert safety at established acceptable daily intake (ADI) levels, accumulating precli...
Cisplatin-induced renal toxicity: an integrated view of molecular pathways and emerging therapeutic targets-a comprehensive review [0.03%]
顺铂致肾毒性：分子通路及新兴治疗靶点的全面综述
Naveen Vijiyakumar,Sabina Evan Prince
Naveen Vijiyakumar
Cisplatin is a widely used chemotherapeutic agent effective against a variety of solid tumors; however, its clinical utility is limited by dose-dependent nephrotoxicity. Cisplatin-induced renal injury involves a complex pathophysiology, inc...