Iodinated Contrast Media Nephrotoxicity: Evolving Mechanisms from Osmotic Stress to Molecular Pathways [0.03%]
碘化对比剂的肾毒性：从渗透压力到分子机制的新认识
Huixian Zhang,Zongli Diao,Wenhu Liu
Huixian Zhang
Iodinated contrast media represent exogenous chemical stressors that can induce renal tubular toxicity, particularly in individuals with pre-existing renal dysfunction. Contrast-induced acute kidney injury (CI-AKI) is increasingly recognize...
Quantitative methods for the risk assessment of drinking water contact chemicals following the NSF/ANSI/CAN 600 Standard - Part II: advanced methods [0.03%]
饮用水消毒副产物致病风险的量化评估方法研究第二部分：高级模型与算法
Bradley Lampe,J Caroline English,L T Haber et al.
Bradley Lampe et al.
Health-based criteria have been developed using quantitative methods for over 370 unregulated chemicals that have been detected in extraction testing of products certified or being certified to NSF/ANSI/CAN 60 (Drinking Water Treatment Chem...
Choriocapillaris and blood flow alterations in smokers naïve to heated tobacco products: a cross-sectional study [0.03%]
关于加热烟草产品的新型使用者的视网膜前毛细血管丛和血流的变化：横断面研究
Marcella Nebbioso,Francesca Calzolaio,Valentina Castellani et al.
Marcella Nebbioso et al.
Purpose: Heated tobacco products (HTPs) are devices that heat tobacco to high temperatures, rather than combusting it to generate smoke. The potential impact of HTPs on the body is not yet fully understood, as they are re...
Analysis of Persistent Organic Pollutants (Organochlorine Pesticides & PCBs) in Livers of Leatherback Sea Turtles (Dermochelys coriacea) by GC-MS/MS [0.03%]
LC-MS/MS法测定棱皮龟肝脏中有机氯农药及PCBs残留分析
Andreas F Lehner,Mark Bokhart,John P Buchweitz et al.
Andreas F Lehner et al.
Persistent organic pollutants (POPs) including chlorinated pesticides (OCPs) and polychlorinated biphenyls (PCBs) are among anthropogenic toxicological stressors of endangered leatherback sea turtles (Dermochelys coriacea). We examined live...
Cereulide-Mediated Emetic (Vomiting) Toxicity of Bacillus cereus in Infant Formula: Mitochondrial Mechanisms, Analytical Methods, and Risk Assessment [0.03%]
婴儿配方奶粉中蜡样芽孢杆菌产生的催吐毒素(催吐毒性):线粒体机制、分析方法和风险评估
Ghassan Sonji,Nada Sonji,Afaf El Katerji
Ghassan Sonji
Cereulide is a heat stable cyclic dodecadepsipeptide and potassium selective ionophore produced by Bacillus cereus, recognized as the causative agent of emetic food poisoning. Data indicate it exerts potent mitochondrial toxicity by collaps...
Combined effects and potential mechanisms of volatile organic compounds on childhood asthma in the US population: an integrated epidemiological and computational toxicology study [0.03%]
美国人口中挥发性有机化合物联合作用对儿童哮喘的综合流行病学及计算毒理学研究
Beizhang Liang,Meizhu Cao,Huiyuan Tan et al.
Beizhang Liang et al.
Background: Childhood asthma is a major public health concern, with its incidence continuing to rise in many industrialized countries. While genetic factors contribute to asthma development, environmental exposures, parti...
Investigation of Perfluorooctanoic Acid Exposure Induced Renal Dysfunction Associated with Oxidative Stress, Fibrosis, and Impaired Angiogenic Signaling in Male Wistar Rats [0.03%]
雄性Wistar大鼠全氟辛酸暴露诱导的肾功能障碍与氧化应激、纤维化和受损血管生成信号有关的研究
Lavanya Hongal,M David
Lavanya Hongal
Perfluorooctanoic acid (PFOA), a persistent per- and polyfluoroalkyl substance, is widely detected in environmental and biological systems and has been associated with renal toxicity. However, the integrated relationship between oxidative s...
Simplified method for measuring volatile organic chemicals in newly manufactured neonatal incubators [0.03%]
新生儿培养箱中挥发性有机物的简易检测方法
Alexander Herman,Alan Hood,Oleg Vesnovsky et al.
Alexander Herman et al.
Neonatal incubators are critical to the care for newborns in hospital settings, such as neonatal intensive care units (NICU). In 2023, the US Food and Drug Administration (FDA) reported that some neonatal incubators could potentially expose...
Mouse precision-cut liver and kidney slices: an optimized ex vivo model for organotoxicity testing [0.03%]
精密切割的小鼠肝肾切片：一种优化的器官毒性检测体外模型
Christiane Spruck,Ghizlan Bousejra,Ahmed Erbay et al.
Christiane Spruck et al.
As excretion organs, the kidneys and liver are exposed to high concentrations of potentially toxic substances. While animal models remain the gold standard for organ-specific toxicity testing, meaningful alternative ex vivo approaches are e...
Computational Toxicology Analysis of Candidate Drivers and Pathways in HRZE-Associated Drug-Induced Liver Injury [0.03%]
HRZE相关药物性肝损伤候选驱动基因和途径的计算毒理学分析
Yehua Lai,Xinyi Yang,Hua Tian et al.
Yehua Lai et al.
The first-line anti-tuberculosis regimen HRZE (isoniazid, rifampicin, pyrazinamide, ethambutol) frequently causes drug-induced liver injury (DILI). However, the mechanisms underlying this combination hepatotoxicity remain unclear. Therefore...