Could e-cigarette devices generate inhalable micro- and nanoplastics? Exposure plausibility and reproductive relevance [0.03%]
电子烟设备能否生成可吸入的微塑料和纳米塑料？暴露可能性及对生殖的相关性分析
Ardie Barry Sailis
Ardie Barry Sailis
Electronic cigarettes are widely used by individuals in their reproductive years, yet polymer materials in pods, wicks, seals, and casings remain underexamined as possible contributors to inhaled particulate exposure. This narrative review ...
Matrine enhances cisplatin sensitivity in oral squamous cell carcinoma through regulation of oxidative stress and apoptosis [0.03%]
小檗胺通过调节氧化应激和凋亡增强顺铂对舌鳞癌的敏感性
Yuqing Xu,Yanlan Yu,Zenan Xu et al.
Yuqing Xu et al.
Cisplatin resistance remains a major limitation in the treatment of oral squamous cell carcinoma (OSCC), often associated with altered oxidative stress. This study aimed to evaluate whether matrine can enhance cisplatin sensitivity in OSCC ...
Hepatotoxic and Nephrotoxic Effects of Etoxazole in Rats: Dose-Response Relationships, Oxidative Stress Mechanisms, and Provisional NOAEL/LOAEL Estimates [0.03%]
乙菌啶致大鼠肝肾毒性的剂量效应关系、氧化应激机制及暂定NOAEL/LOAEL值评估研究报告
Bedia Bati,Neşe Eray Vuran,Ahmet Dündar et al.
Bedia Bati et al.
Etoxazole (ETX) is a widely used organofluorine acaricide/insecticide applied to many food crops, and its residues have been detected in food matrices at levels of concern for human dietary exposure. However, its hepatotoxic and nephrotoxic...
Glycycoumarin ameliorates pyroptosis in autoimmune hepatitis by activating autophagy and reducing NLRP3 inflammasome activation [0.03%]
甘葛根素通过激活自噬和减少NLRP3炎性小体活化来改善自身免疫性肝炎中的焦亡作用
Qian Gao,Yiqun Zhou,Jun Shi et al.
Qian Gao et al.
Objective: This study explored the protective effect of glycycoumarin (GCM) against autoimmune hepatitis (AIH) and its underlying mechanisms. Methods: ...
Combined treatment of zingerone and nilotinib induces cytotoxicity and reverses nilotinib resistance in chronic myeloid leukemia cells via inhibition of the PI3K signaling [0.03%]
姜辣素与尼洛替尼联合治疗通过抑制PI3K信号通路诱导慢性髓系白血病细胞毒性及逆转尼洛替尼耐药性
Chong Chen,Fang Wang,Suludefu
Chong Chen
Introduction: Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML) treatment; however, TKI resistance remains a persistent challenge. This study investigates the effects of...
Dissociating hepatocellular necrosis from hepatic encephalopathy: a murine acetaminophen model to identify second-hit drivers of acute liver failure [0.03%]
一种小鼠对乙酰氨基酚模型将肝细胞坏死与肝性脑病分离以识别急性肝衰竭的二次打击驱动因素
Jenna Strickland,Yining Jin,Cheryl E Rockwell et al.
Jenna Strickland et al.
Acetaminophen (i.e. paracetamol; APAP) overdose is the most common cause of acute liver injury in the United States, yet outcomes range from recovery to acute liver failure (ALF), defined by coagulopathy and hepatic encephalopathy (HE). Cli...
Comprehensive Assessment of Hyperoside: Cytotoxic, Anti-cancer, Genoprotective, Radical Scavenging and Computational Toxicity Properties through In Vitro and In Silico Approaches [0.03%]
hyperoside的全面评估：通过体外和计算方法研究其细胞毒性，抗肿瘤性，基因保护性，自由基清除能力和计算毒性属性
Aysen Yagmur Burgazli,Ece Avuloglu Yilmaz,Sevcan Mamur et al.
Aysen Yagmur Burgazli et al.
Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach. Cytotox...
Predictive modeling of urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG) in metal workers: A comparative study of machine learning algorithms in toxicology [0.03%]
金属工人尿液中8-羟基脱氧鸟苷的预测建模：毒理学中机器学习算法的比较研究
Ali Sani,Ibrahim Lawal Abdullahi
Ali Sani
Urinary 8-hydroxy-2´-deoxyguanosine (8-OHdG), a biomarker for oxidative DNA damage, is commonly used to assess the repair of reactive oxygen species (ROS) induced DNA damage. This study developed predictive models to quantify 8-OHdG concen...
The mechanism of the PI3K/akt/NF-κB pathway in wasp venom-induced acute liver injury in rats: a preliminary study [0.03%]
PI3K/akt/NF-κB信号通路在黄蜂毒液致大鼠急性肝损伤中的作用机制初步研究
Fangfang Deng,Ronghui Chen,Wenxin Luo et al.
Fangfang Deng et al.
Objective: This study aims to preliminarily investigate the regulatory role of the PI3K/Akt/NF-κB signaling pathway in the process of wasp venom-induced acute liver injury. ...
Sevoflurane pre-treatment attenuates myocardial cell ferroptosis caused by hypoxia and reoxygenation via regulating lncRNA NNT-AS1 [0.03%]
异氟醚预处理通过调节长链非编码RNA NNT-AS1抑制缺氧复氧诱导的心肌细胞铁死亡
Zanhui Gong,Yajun Wu,Yongsheng Wang et al.
Zanhui Gong et al.
Myocardial ischemia-reperfusion injury (MIRI) is the primary cause of death for acute myocardial infarction. LncRNA NNT-AS1 was upregulated in the H9c2 hypoxia-reoxygenation (H/R) model. However, the interaction between sevoflurane and NNT-...