Toxicity of brominated flame retardants, BDE-47 and BDE-99 stems from impaired mitochondrial bioenergetics [0.03%]
溴化阻燃剂BDE-47和BDE-99的毒性源自线粒体生物能量动力学受损
Murilo Pazin,Lilian Cristina Pereira,Daniel Junqueira Dorta
Murilo Pazin
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants, and they have been detected in human blood, adipose tissue and breast milk, a consequence of their physicochemical and bioaccumulative properties, as well as their high en...
Comparative Study
Toxicology mechanisms and methods. 2015 Jan;25(1):34-41. DOI:10.3109/15376516.2014.974233 2015
Clinical and biochemical analysis of acute paint thinner intoxication in adults: a retrospective descriptive study [0.03%]
成人急性溶剂中毒的临床和生化分析：回顾性描述性研究
Hamid Reza Rahimi,Khosrow Agin,Shahin Shadnia et al.
Hamid Reza Rahimi et al.
Context: Paint thinner contains a mixture of various aromatic hydrocarbons. A few studies have reported biochemical abnormalities and clinical symptoms of paint thinner intoxication among adult patients. ...
Study on lead-induced activation of rat renal interstitial fibroblasts and the related mechanisms [0.03%]
铅致大鼠肾间质成纤维细胞活化及其机制研究
Lin Han,Rong Zhou,Xingya Kuang et al.
Lin Han et al.
Context: Lead is a common industrial toxicant and has been proved to be associated with the kidney damage. Objective: To investigate th...
Benidipine prevents oxidative stress, inflammatory changes and apoptosis related myofibril damage in isoproterenol-induced myocardial infarction in rats [0.03%]
苯地平对异丙肾上腺素诱导的大鼠心肌梗死氧化应激、炎症变化和与肌丝损伤相关凋亡的预防作用
Md Quamrul Hassan,Md Sayeed Akhtar,Mohd Akhtar et al.
Md Quamrul Hassan et al.
Objective: The effects of benidipine on oxidative stress and myocardial apoptosis were assessed in isoproterenol (ISO)-induced myocardial infarction (MI) in wistar rats. ...
Safety and toxicological evaluation of a novel, fermented, peptide-enriched, hydrolyzed swine placenta extract powder [0.03%]
一种新型的发酵的富含肽的水解胎盘提取粉的安全性和毒理学评价
Yukio Mitsui,Manashi Bagchi,Palma Ann Marone et al.
Yukio Mitsui et al.
Placenta is an important organ that connects the developing fetus to allow nutrient uptake, antibody provisions and gas exchange via the blood supply of the mother. We developed a novel, standardized, stable, water-soluble, peptide-enriched...
Abnormal olanzapine toxicokinetic profiles--population pharmacokinetic analysis [0.03%]
奥兰扎平中毒毒代动力学异常-人群药代动力学分析
Zofia Tylutki,Wojciech Jawień,Krzysztof Ciszowski et al.
Zofia Tylutki et al.
Context: Olanzapine is widely used in the treatment of schizophrenia and it is becoming more frequently responsible for overdoses. Standard pharmacokinetic models do not fit to the toxic concentration data. ...
Analysis of apoptosis induced by perfluorooctane sulfonates (PFOS) in mouse Leydig cells in vitro [0.03%]
全氟辛烷磺酸诱导小鼠支持细胞/间质细胞凋亡的体外分析
De-Yong Zhang,Xiao-Lu Xu,Xiu-Ying Shen et al.
De-Yong Zhang et al.
To explore the possible mechanism of perfluorooctane sulfonates (PFOS's) reproductive toxicity, mouse Leydig cells cultured in vitro were exposed to a serial concentration of PFOS for four more days of culture. Apoptosis during the process ...
Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes [0.03%]
雌性激素类药物喹斯托隆诱导成年大鼠睾丸生精细胞凋亡的线粒体途径和Fas配体介导途径参与作用
Jian Li,Funing Chen,Yaoxing Chen et al.
Jian Li et al.
The pathways involved in quinestrol-induced spermatogenic apoptosis were studied in adult male rat by using daily intragastric administration of 0.01 mg/kg, 0.1 mg/kg and 1 mg/kg body weight quinestrol for two consecutive weeks. The immunoh...
Pre-pubertal exposure of cytarabine-induced testicular atrophy, impaired spermatogenesis and germ cell DNA damage in SD rats [0.03%]
CYAR诱导的大鼠青春期前睾丸萎缩、生精障碍及生精细胞DNA损伤效应研究
Ramana C Namoju,Sabbir Khan,Ronak S Patel et al.
Ramana C Namoju et al.
Context: Cytarabine (Ara-C) is an effective chemotherapeutic drug for the treatment of acute leukaemias. It inhibits the DNA synthesis and repair, thereby causes cytotoxicity in the proliferating cells. ...
Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway [0.03%]
莱伏氟沙星通过Bax/Bcl-2/caspase-3途径增强大鼠椎间盘细胞anoikis效应
Si-Dong Yang,Zhi-Long Bai,Feng Zhang et al.
Si-Dong Yang et al.
Levofloxacin, a fluoroquinolone, is a widely-used and effective antibiotic. However, various adverse side effects are associated with levofloxacin. The purpose of this study was to further explore the effects of levofloxacin on rat nucleus ...