Cross-dataset transcriptomic pathway ranking highlights MAPK signaling in diquat-induced hepatocellular toxicity [0.03%]
跨数据集转录组通路排名揭示MAPK信号在百草枯诱导的肝细胞毒性中的作用
Ngoc U Nguyen,Christopher Tong,Madeline M Fry et al.
Ngoc U Nguyen et al.
Diquat is used in agriculture as an herbicide but poses significant health risks upon exposure. Current treatment for toxic exposures to diquat focuses on supportive care, and there is a need for better understanding of the molecular mechan...
Oxidative Stress Contributes to Coffee Constituent Toxicity in SH-SY5Y Neuroblastoma Cells [0.03%]
氧化应激参与咖啡成分对神经母细胞瘤SH-SY5Y细胞的毒性作用
Susan Hall,John Yuen,Shailendra Anoopkumar-Dukie et al.
Susan Hall et al.
Coffee is a widely consumed beverage that has been shown to have numerous health benefits including positive effects on neurological and psychological conditions including depression. Although positive benefits have been observed, some epid...
A rapid behavioral toxicity test using common periwinkle Littorina littorea (Gastropoda: Littorinidae) [0.03%]
利用滨螺(Littorina littorea)的快速行为毒理学测试
Bjørn Henrik Hansen,Amaia Igartua,Raymond Nepstad et al.
Bjørn Henrik Hansen et al.
Chemical pollution threatens the balance, resilience and health of coastal ecosystems, and there is a need for relevant tools to monitor and assess the sensitivity of these vital ecosystems. The common periwinkle (Littorina littorea) is a k...
Efficient and Rapid Drug of Abuse Testing Using ACCU-TELL® Multi 7 Drug Panel Cup Test (Urine) [0.03%]
使用ACCU-TELL多七种药物检测试纸(尿液)进行高效的滥用药物检测
Ebtisam Abdulrahman Alabdooli,Faisal Mohammed Alteneiji,Huda Suliman Saeed et al.
Ebtisam Abdulrahman Alabdooli et al.
Drug abuse screening is a public health and legal priority in the United Arab Emirates (UAE), where rapid and accurate detection is critical in workplaces, healthcare, and forensic settings. This study evaluates the diagnostic performance o...
Computational evidence of cancer and reproductive toxicological potential from short-chain PFAS exposure through network toxicology and docking approaches [0.03%]
基于网络毒理学和对接方法的全氟烷基物质通过短链暴露致癌症及生殖毒性计算证据
Vedika Jain,Sharda Bharti
Vedika Jain
Short-chain per- and polyfluoroalkyl substances (PFAS) are increasingly being used as substitutes for long-chain PFAS due to their lower bioaccumulation potential. However, their persistence and mobility can lead to toxicity and pose signif...
Lipidomic reveals potential mediators of associations between lead exposure and Alzheimer's disease [0.03%]
脂质组学揭示了铅暴露与阿尔茨海默病关联的潜在介质
Hong-Mei Gan,Cui-Ju Liu,Rong-Juan Jiang et al.
Hong-Mei Gan et al.
Previous studies have identified associations between lead (Pb) exposure and the incidence of Alzheimer's disease (AD), yet the underlying mechanisms are still missing. This investigation verified the association between Pb exposure burden ...
Potential of Fenfuro®, a novel, standardized Trigonella foenum-graecum (Fenugreek) seed extract, in ameliorating glycation-mediated amyloidogenesis [0.03%]
一种新型的、可标准化的香草豆属植物（香草豆种子）提取物Fenfuro®在改善糖基化介导的淀粉样蛋白生成方面的潜力
Sreemoyee Saha,Pawan Kumar,Manashi Bagchi et al.
Sreemoyee Saha et al.
The potential of Trigonella foenum-graecum or fenugreek seed extract in alleviating chronic hyperglycemia is supported by scientific evidence. In addition to its role in optimizing the insulin signaling pathway, fenugreek extract can also p...
Mitochondria Under Fire: Toxicological Mechanisms of Brominated Flame Retardants [0.03%]
mitochondria under fire：溴系阻燃剂的毒性作用机制
Raul Ghiraldelli Miranda,Ivo F Machado,Anabela Pinto Rolo et al.
Raul Ghiraldelli Miranda et al.
Brominated flame retardants (BFRs) are ubiquitous and persistent environmental contaminants owing to their extensive use in consumer products. Although linked to various adverse health effects, the underlying molecular mechanisms remain com...
L-Arginine and Tetrahydrobiopterin Alleviate Mercury-Induced Vascular Dysfunction by Modulating Angiotensin II Receptors (AT1, AT2) and ACE2 Activity in Rat Aortic Rings [0.03%]
L-精氨酸和四氢生物蝶呤通过调节血管紧张素II受体（AT1、AT2）和ACE2活性缓解汞诱导的血管功能障碍：大鼠主动脉环模型研究
Zana H Ibrahim,Ridha H Husein,Ismail M Maulood
Zana H Ibrahim
Background: Cardiovascular diseases are often driven by oxidative stress and endothelial dysfunction, particularly under heavy metal exposure such as HgCl2. It disrupts NO signaling and RAS balance, impairing vascular fun...
Radioprotection or radiosensitization? Unraveling caffeine's bifurcated effects on radiation-induced damage [0.03%]
辐射防护还是放射增敏？解密咖啡因对辐射诱导损伤的双重效应
Habibeh Mashayekhi-Sardoo,Kiana Aftabi,Ali Azami et al.
Habibeh Mashayekhi-Sardoo et al.
Caffeine, a widely consumed phytochemical, exhibits a dual and paradoxical role in modulating cellular responses to radiation, acting as both a radioprotector and radiosensitizer depending on context. This comprehensive review synthesizes e...