Endpoint Governance and Reporting Transparency in Biomarker-Guided Oncology Trials: A Systematic Review, 2015 to 2024 [0.03%]
2015至2024年基于生物标志物的肿瘤药物临床试验的终点管理和报告透明度系统评价
Fidelis Nwachukwu,Mary Obimma
Fidelis Nwachukwu
Biomarker-guided oncology trials frequently prioritize surrogate endpoints to enable efficient development in molecularly defined populations, often before mature overall survival (OS) data are available. We conducted a PRISMA 2020-guided s...
Xingcan Fan,Yulin Song,Qiuyu Liao et al.
Xingcan Fan et al.
Mesenchymal-epithelial transition factor (c-MET) is a pivotal receptor tyrosine kinase that mediates tumor initiation, progression and metastasis through abnormal signaling activation, representing a promising therapeutic target across mali...
Clinical Features, Treatment Patterns, and Outcomes of Solitary Plasmacytoma in the United States: A National Cancer Database (NCDB) Analysis of Years 2004 to 2020 [0.03%]
美国2004年至2020年单发浆细胞瘤的临床特征、治疗模式和结局：国家癌症数据库(NCDB)分析结果
Ludovic Saba,Gaelle C Haddad,John Greskovich et al.
Ludovic Saba et al.
Objectives: Solitary plasmacytoma is a rare plasma cell neoplasm with varying outcomes. This large IRB-approved retrospective analysis used the National Cancer Database (NCDB) to assess prognostic factors, treatment patte...
Conditional Survival Estimates for Malignant Glioma Patients: Secondary Analysis of RTOG 9006 [0.03%]
恶性胶质瘤患者的条件生存率估计：RTOG 9006试验的二次分析研究
Matthew H Brown,Hua-Ren R Cherng,James W Assif et al.
Matthew H Brown et al.
Objectives: Conditional survival (CS) provides estimates of how survival changes over time. The primary objective of this secondary analysis is to report CS estimates for patients with malignant gliomas enrolled on RTOG 9...
Primary Central Nervous System Melanoma (pCNSM) and Treatment Protocols: A Literature Review [0.03%]
原发性中枢神经系统黑色素瘤(pCNSM)及其治疗方案：文献回顾
Yasmine Elsherif,Nouman Aziz,Omar Elsherif et al.
Yasmine Elsherif et al.
Primary central nervous system melanoma (pCNSM) is an exceptionally rare malignancy arising from melanocytes of neural crest origin, with an annual incidence of just 0.005 per 100,000 individuals. Due to its rarity and the heterogeneity in ...
Radiotherapy Utilization Patterns Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A National Claims Database Study [0.03%]
转移性肾细胞脊柱癌患者的放射治疗模式：一项全国索赔数据库研究
Tobechukwu C Ndika,Emily J Luo,Joshua Woo et al.
Tobechukwu C Ndika et al.
Objectives: This study aimed to identify sociodemographic predictors of stereotactic body radiotherapy (SBRT) use and assess temporal trends in first-line SBRT use among patients with spinal metastatic renal cell carcinom...
Efficacy and Safety of Pulsed Low-Dose Rate Radiotherapy in Re-Irradiation of Recurrent Solid Tumors: A Single-Center Retrospective Study [0.03%]
复发实性肿瘤多次放疗的疗效及安全性：脉冲低剂量率放射治疗回顾性研究
Xinyan Zhang,Zifang Liu,Huacong Jin et al.
Xinyan Zhang et al.
Objective: To evaluate the efficacy and safety of pulsed low-dose rate (PLDR) radiotherapy in the re-irradiation of recurrent solid tumors. Methods: ...
Adjuvant Chemotherapy After Curative Intent Resection of Ampullary Cancer (ADAPTA): Study Protocol for a Pan-European Prospective Multicenter Double Single Arm Trial [0.03%]
术后辅助化疗以治愈为目的的壶腹癌手术（ADAPTA）：欧洲前瞻性多中心双单臂试验研究方案
Bas A Uijterwijk,Daniel H L Lemmers,Dorine S Klei et al.
Bas A Uijterwijk et al.
Objectives: Ampullary adenocarcinoma (AAC) is rare. Five-year survival rates of 30% to 70% are seen after resection. This broad range of survival could be explained by the morphologic heterogeneity in the 3 subtypes of AA...
Enhancing the Diagnostic Performance of Early Lung Cancer by Integrating Multiplex Nucleic Acid Aptamer Detection With Conventional Tumor Markers: A Prospective Observational Study [0.03%]
通过整合多重核苷酸核酸适体检测与常规肿瘤标志物提升早期肺癌诊断性能：一项前瞻性观察研究
Hongxia Yuan,Weijun Wang,Zhengli Wei et al.
Hongxia Yuan et al.
Objectives: To evaluate the value of incorporating multiplex nucleic acid aptamer detection into conventional serum tumor marker testing for improving the early diagnosis of lung cancer. ...
FDA-Approved Radiopharmaceuticals in Oncologic PET Imaging: Current Status and Clinical Impact [0.03%]
美国食品药品监督管理局批准的用于正电子发射断层扫描肿瘤显像的放射性药物：现状和临床影响
Gaurav Agarwal,Kavita Sangwan
Gaurav Agarwal
Cancer persists as a formidable adversary to human health, with its early-stage detection posing a persistent and intricate challenge. While radiologic imaging serves as a cornerstone in the diagnostic arsenal for oncological conditions, th...