Safety and Efficacy of Palbociclib and Endocrine Therapy Versus Endocrine Therapy Alone in HR+/HER 2- Breast Cancer Patients; a Systematic Review and Meta-Analysis [0.03%]
帕博西尼联合内分泌治疗与单纯内分泌治疗HR+/HER 2-乳腺癌患者的疗效和安全性：系统评价和 meta 分析
Faiza Fatima,Muhammad I Bhatti,Ahmed Raza et al.
Faiza Fatima et al.
Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have emerged as novel agents in the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. Palbociclib, w...
Real-World Outcomes of Adjuvant Immunotherapy and Radiation Therapy for Stage III Merkel Cell Carcinoma [0.03%]
III期默克尔细胞癌术后免疫治疗与放疗的预后研究
Natalie N Chakraborty,Trisha Lal,Iris Sheng et al.
Natalie N Chakraborty et al.
Objectives: Immune checkpoint inhibitors demonstrate meaningful promise in advanced unresectable Merkel cell carcinoma (MCC), but their role in the adjuvant setting is evolving. We assessed the association between adjuvan...
Hepatobiliary Toxicity Following Ablative Radiation for Centrally Located Hepatocellular Carcinoma [0.03%]
中心型原发性肝癌根治性放疗的肝胆毒性分析
Sarah Feldkamp,Bailey Nelson,Kyle Wang et al.
Sarah Feldkamp et al.
Objectives: Centrally located hepatocellular carcinoma (CL-HCC) poses a therapeutic challenge due to proximity to the central hepatobiliary tract (cHBT) and concern for radiation-related toxicity. We evaluated hepatobilia...
Targeted CysLTR1 Blockade Rescues Myeloid-Mediated Resistance to Immune Checkpoint Inhibition in Solid Malignancies: A Combined Genomic, Emulated Clinical Trial, and Epidemiological Negative-Control Analysis [0.03%]
针对实体瘤中髓系细胞介导的免疫检查点抑制抵抗的治疗：结合基因组、模拟临床试验和流行病学阴性对照分析发现CysLTR1阻断可改善抗肿瘤免疫响应
Steven Lehrer,Peter Rheinstein
Steven Lehrer
Objectives: Myeloid-driven inflammation contributes to resistance to immune checkpoint inhibitors (ICIs) in solid tumors, partly through neutrophil-mediated immunosuppressive mechanisms. Experimental evidence suggests cys...
Single-Cell Transcriptomic Analysis Reveals γδ T-Cell Infiltration and Presence of Immune Regulatory Molecules in Biliary Tract Cancer Microenvironment [0.03%]
单细胞转录组分析揭示胆道癌微环境中γδT细胞浸润及免疫调节分子的存在
Saikat Mandal,Stuart Astbury,Jane I Grove et al.
Saikat Mandal et al.
Objectives: Biliary tract cancer (BTC) remains therapeutically challenging with poor survival outcomes; systemic therapies achieving complete responses in only 2% to 5% of patients. γδ T-cell-based adoptive cell therapy...
Care Patterns and Gastric Cancer-Related Outcomes in Patients With Pathogenic/Likely Pathogenic Germline CDH1 Variants: A 14-Year Single-Center Analysis [0.03%]
CDH1基因致病/可能致病性种系变异患者的护理模式和胃癌相关结局：一项为期14年的单中心分析
Robert Schoeneich,Rishi R Patel,Bohae R Lee et al.
Robert Schoeneich et al.
Objectives: Hereditary diffuse gastric cancer (HDGC) due to germline CDH1 pathogenic or likely pathogenic (P/LP) variants has traditionally been managed with prophylactic total gastrectomy (PTG), although contemporary dat...
Upper Extremity Lymphedema: Performance of a Risk Prediction Model in Women Undergoing Surgery for Breast Cancer [0.03%]
乳腺癌术后发生上肢淋巴水肿风险预测模型的验证及列线图制定
Alessandra Mendes Silva,Samantha K Lopes de Almeida Rizzi,Fernanda Baptista Rodrigues et al.
Alessandra Mendes Silva et al.
Introduction: Upper extremity lymphedema is a common complication following breast cancer treatment, and supportive tools are valuable for screening, preventive strategies, and early therapeutic intervention. In 2020, Kwa...
Executive Summary of the American Radium Society (ARS) Appropriate Use Criteria (AUC) for the Use of Radiation in the Prevention and Treatment of Heterotopic Ossification (HO) [0.03%]
美国放射学会（ARS）关于放射性药物在异位骨化（HO）预防和治疗中的适当应用准则（AUC）的概要说明
Austin Dove,Phillip Bennion,Sam Jean-Baptiste et al.
Austin Dove et al.
Objectives: To summarize the current evidence for radiation therapy (RT) in the prevention and treatment of heterotopic ossification (HO), including patient selection, optimal RT technique, and associated risks. ...
Stereotactic Body Radiation Therapy Combined With Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma: A Comprehensive Single-Arm Meta-Analysis Approach [0.03%]
立体定向体放射治疗联合免疫检查点抑制剂治疗不可切除的肝细胞癌：单臂综合荟萃分析方法
Justin Dreyer,Raksha M Narasimhan,Ana R Dias Neto et al.
Justin Dreyer et al.
Objectives: In locally advanced hepatocellular carcinoma (HCC), immune checkpoint inhibitors (ICI) are the frontline regimen, but the benefit of stereotactic body radiation (SBRT) in combination is unclear. Given randomiz...
Emergence of Single-Week Adjuvant Radiation Therapy for Early-Stage Breast Cancer in the United States [0.03%]
美国单周序贯放疗作为乳腺癌辅助治疗的应用现状及趋势分析
Nimisha Kasliwal,Marie Gordon,Evan Becker et al.
Nimisha Kasliwal et al.
Objectives: Over the past 2 decades, adjuvant radiation therapy (RT) for early-stage breast cancer has shifted toward shorter regimens. While initially occurring over 5 to 6 weeks, level 1 evidence has supported the equiv...