The Role of Lactate Metabolism in Tumors: From Metabolic Byproduct to Signaling Molecule [0.03%]
肿瘤乳酸代谢的作用：从代谢副产物到信号分子
Zhenghui Tian,Kexin Zhang,Sufang Sheng et al.
Zhenghui Tian et al.
Lactate, once viewed as a metabolic by-product of glycolysis, is now recognized as a central regulator in cancer biology. Accumulating evidence reveals that lactate actively participates in tumor progression by functioning as a metabolic fu...
Contributing Factors to Delay of Adjuvant Postsurgical Radiation for Malignant Brain Tumors: A Single Institution Experience in a Rural State [0.03%]
美国农村地区单个机构关于恶性脑肿瘤术后辅助放疗延迟的影响因素分析
Grace Guzman,Ghassan Makhoul,Sahana Bettadapura et al.
Grace Guzman et al.
Objectives: Malignant tumors of the central nervous system (CNS) are associated with high morbidity and mortality, requiring prompt and coordinated multidisciplinary care. Although adjuvant radiotherapy (RT) is a standard...
Prognostic Value of Multiparameter Biomarkers in Pleural Effusion of Patients With Non-small Cell Lung Cancer for Predicting Survival Outcomes: A Prospective Cohort Study [0.03%]
一项前瞻性队列研究：肺癌患者胸腔积液多参数生物标志物对预后价值及其预测生存结局的作用
Dan Yang,Bao-Hong Cui,Hui-Yan Wang et al.
Dan Yang et al.
Objective: Pleural effusion is a frequent and clinically significant complication in patients with non-small cell lung cancer (NSCLC), frequently causing debilitating respiratory symptoms, most notably dyspnea. The develo...
Jessica J Bai,Kyle A Mani,Daxuan Deng et al.
Jessica J Bai et al.
Objectives: Patients with cancer may be at higher risk of heart disease from anticancer therapies. However, there is limited data on the risks of heart disease mortality after primary cancer site surgery. This study sough...
Elizabeth O Olatunji,Benjamin K Talom,Ena C Oboh et al.
Elizabeth O Olatunji et al.
Cancer is a major health threat in sub-Saharan Africa (SSA). Patient navigation has emerged as a strategy to address this, but the scope and impact of patient navigation for cancer care in SSA remains unclear. We aimed to comprehensively ma...
Real World Radiographic Response Rates and Preoperative Attrition in Patients With Non-Small Cell Lung Cancer (NSCLC) Treated With Neoadjuvant Chemoimmunotherapy [0.03%]
新辅助化疗免疫治疗非小细胞肺癌（NSCLC）的术前流失和真实世界的放射学反应率
Cole Friedes,Michelle Iocolano,Nikhil Yegya-Raman et al.
Cole Friedes et al.
Objectives: To evaluate real-world rates of radiographic response and surgery in patients treated with neoadjuvant chemoimmunotherapy for stage II to III NSCLC. ...
Benjamin K Talom,Christina C Huang,Monique N Westley et al.
Benjamin K Talom et al.
Objectives: Academic promotion in radiation oncology is influenced by multiple factors, including scholarly productivity and demographic characteristics. While citation-based metrics such as the h-index are increasingly u...
A Phase 2 Trial of Protein Kinase C Iota Inhibition With the Combination of Auranofin and Sirolimus in Patients With Recurrent Ovarian Cancer [0.03%]
一项针对复发性卵巢癌患者的蛋白激酶C iota抑制联合金诺芬和雷帕霉素二期临床试验
Aminah Jatoi,Nathan R Foster,Andrea Wahner Hendrickson et al.
Aminah Jatoi et al.
Objectives: This trial served as a proof-of-concept for whether inhibition of protein kinase C iota (PKCι) with auranofin and sirolimus provide antineoplastic effects in patients with recurrent high-grade serous ovarian ...
Demographic and Regional Trends in Mortality Related to Cholangiocarcinoma in the United States: 1999 to 2020 [0.03%]
1999至2020年美国胆管癌死亡的地域和人口统计学变化趋势
Adeena Jamil,Nouman Aziz,Zunaira Saeed et al.
Adeena Jamil et al.
Objectives: Cholangiocarcinoma is the second most common primary liver tumor with a highly aggressive course and poor prognosis (5-year survival ≤15%). Here, we assessed trends in regional and demographic differences in ...
Impact of Patient Navigation on Radiation Therapy Completion in Black Breast Cancer Patients: Early Phase I Trial Results From the Navigator-Assisted Hypofractionation (NAVAH) Program [0.03%]
患者导航对黑人乳腺癌放射治疗完成度的影响：来自导航辅助低分割放疗（NAVAH）项目一期临床试验的初步结果分析
Shearwood McClelland rd,Ursula Burnette,Louisa Onyewadume et al.
Shearwood McClelland rd et al.
Objectives: Black breast cancer patients have substantially decreased access to optimal breast-conserving cancer care than white patients. Patient navigation has never been formally implemented into the receipt of radiati...