A Novel 8-Predictors Signature to Predict Complicated Disease Course in Pediatric-onset Crohn's Disease: A Population-based Study [0.03%]
一种新的8种标志物组合标记用于预测儿童期起病的克罗恩病患者疾病发展情况：基于人口队列的研究
Hélène Sarter,Guillaume Savoye,Guillemette Marot et al.
Hélène Sarter et al.
Background: The identification of patients at high risk of a disabling disease course would be invaluable in guiding initial therapy in Crohn's disease (CD). Our objective was to evaluate a combination of clinical, serolo...
Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis [0.03%]
内源性神经营养因子-4的缺失限制了IL-10受体中和结肠炎期间的适应性免疫反应
Jessica K Bernard,Edie B Bucar,Cambrian Y Liu et al.
Jessica K Bernard et al.
Background: Growth factors are essential for maintenance of intestinal health. We previously showed that exogenous neuregulin-4 (NRG4) promotes colonocyte survival during cytokine challenge and is protective against acute...
Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease [0.03%]
炎症性肠病患者英夫利西单抗、维多珠单抗和C反应蛋白浓度监测的居家毛细血管血自我取样技术的临床验证
Antonius T Otten,Hedwig H van der Meulen,Maurice Steenhuis et al.
Antonius T Otten et al.
Background: Therapeutic drug monitoring provides important guidance for treatment of patients with inflammatory bowel disease (IBD) and could help to early identify treatment failure. This study aimed to validate a finger...
A Phase I Study of Ex Vivo Expanded Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Pediatric Perianal Fistulizing Crohn's Disease [0.03%]
儿童肛周瘘管性克罗恩病的体外骨髓来源间充质干细胞治疗I期临床研究
Amy L Lightner,Ana Otero-Pineiro,Jane Reese et al.
Amy L Lightner et al.
Background: Perianal fistulizing Crohn's disease is notoriously difficult to treat. Recent studies of mesenchymal stem cells have demonstrated safety and efficacy of this novel treatment approach. However, no studies to d...
Multiple Orocutaneous Extraintestinal Manifestations in Ulcerative Colitis Patient: Complete Response to Ustekinumab [0.03%]
溃疡性结肠炎患者的多种皮外表现对乌司奴单抗治疗有完全反应
Claudia Carpineti,Cristina Mugheddu,Marta Cadoni et al.
Claudia Carpineti et al.
Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease [0.03%]
性二倍体分析在炎症性肠病中识别出新型的及与性别有关的遗传关联
Michelle Khrom,Dalin Li,Takeo Naito et al.
Michelle Khrom et al.
Background: Sex is an integral variable often overlooked in complex disease genetics. Differences between sexes have been reported in natural history, disease complications, and age of onset in inflammatory bowel disease ...
Impact of Inflammatory Bowel Disease on Patients' Caregivers: Results From a French Survey [0.03%]
炎症性肠病对患者照顾者的影响——法国一项调查的结果
Weam El Hajj,Anne Buisson,Alain Olympie et al.
Weam El Hajj et al.
Background: The impact of inflammatory bowel disease (IBD) on caregivers has rarely been investigated. Our work aims to explore the burden of IBD on the different aspects of caregivers' lives. ...
Creeping Fat in the Pathogenesis of Crohn's Disease: An Orchestrator or a Silent Bystander? [0.03%]
克罗恩病发病机制中侵润脂肪的作用：幕后操纵者还是沉默旁观者？
Efthymios P Tsounis,Ioanna Aggeletopoulou,Athanasia Mouzaki et al.
Efthymios P Tsounis et al.
Although the phenomenon of hypertrophied adipose tissue surrounding inflamed bowel segments in Crohn's disease has been described since 1932, the mechanisms mediating the creeping fat formation and its role in the pathogenesis of the diseas...
One-Year Clinical Outcomes of Subcutaneous Infliximab Maintenance Therapy Compared With Intravenous Infliximab Maintenance Therapy in Patients With Inflammatory Bowel Disease: A Prospective Cohort Study [0.03%]
英夫利西单抗皮下注射维持治疗与静脉注射维持治疗炎症性肠病患者1年临床疗效的队列研究
Sung Noh Hong,Joo Hye Song,Sung Jin Kim et al.
Sung Noh Hong et al.
Background: Although the pharmacokinetic profile of subcutaneous (SC) infliximab (IFX) is superior to conventional intravenous (IV) IFX, long-term efficacy and safety of SC IFX in patients with inflammatory bowel disease ...
Use of Immune Checkpoint Inhibitors in Patients With Inflammatory Bowel Disease After Ileal Pouch-Anal Anastomosis [0.03%]
免疫检查点抑制剂在回肠储袋肛管吻合术后炎症性肠病患者中的应用
Christian Karime,Francis A Farraye,Jana G Hashash
Christian Karime