Mucosal α4β7+ Lymphocytes and MAdCAM+ Venules Predict Response to Vedolizumab in Ulcerative Colitis [0.03%]
黏膜α4β7+淋巴细胞和MAdCAM+静脉在溃疡性结肠炎患者 vedolizumab治疗中的预测作用
Britt Roosenboom,Peter J Wahab,Carolijn Smids et al.
Britt Roosenboom et al.
Background: Therapeutic strategies for patients with ulcerative colitis (UC) are based on patient- and disease-related factors in combination with drug characteristics but fail to predict success in individual patients. A...
Oral Omilancor Treatment Ameliorates Clostridioides difficile Infection During IBD Through Novel Immunoregulatory Mechanisms Mediated by LANCL2 Activation [0.03%]
通过激活LANCL2的新型免疫调节机制介导的口服Omilancor治疗改善IBD患者的难辨梭菌感染
Nuria Tubau-Juni,Josep Bassaganya-Riera,Andrew J Leber et al.
Nuria Tubau-Juni et al.
Background: Clostridioides difficile infection (CDI) is an opportunistic infection of the gastrointestinal tract, commonly associated with antibiotic administration, that afflicts almost 500 000 people yearly only in the ...
Prognostic Value of Inflammatory Bowel Disease-associated Biomarkers in Patients With Immune Checkpoint Inhibitor Enterocolitis: A Retrospective Cohort Study [0.03%]
炎症性肠病相关生物标志物在免疫检查点抑制剂引起的结肠炎患者中的预后价值：一项回顾性队列研究
Lawrence Kogan,Matthew J Townsend,Dhanya Raj et al.
Lawrence Kogan et al.
Glycolytic Activation of CD14+ Intestinal Macrophages Contributes to the Inflammatory Responses via Exosomal Membrane Tumor Necrosis Factor in Crohn's Disease [0.03%]
克罗恩病中肠道CD14+巨噬细胞糖酵解活化通过外泌体膜肿瘤坏死因子促炎症反应
Ziwei Zeng,Sijing Cheng,Xuanna Li et al.
Ziwei Zeng et al.
Background: Macrophage (Mφ) activation plays a critical role in the inflammatory response. Activated Mφ go through profound reprogramming of cellular metabolism. However, changes in their intracellular energy metabolism...
Cong Dai,Yu-Hong Huang
Cong Dai
Lack of Seroconversion Following COVID-19 Vaccination Is an Independent Risk Factor for SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: Data from ESCAPE-IBD, an IG-IBD Study [0.03%]
炎症性肠病患者接种新冠疫苗后缺乏血清学转化是SARS-CoV-2感染的独立危险因素：ESCAPE-IBD研究数据(IBD国际工作组发表)
Fabio Salvatore Macaluso,Mariabeatrice Principi,Federica Facciotti et al.
Fabio Salvatore Macaluso et al.
Real-world Evidence Comparing Tofacitinib and Vedolizumab in Anti-TNF-experienced Patients With Ulcerative Colitis [0.03%]
溃疡性结肠炎抗TNF治疗失败患者的托法替尼与维多珠单抗的现实世界证据对比研究
Sruthi Adimadhyam,James D Lewis,Andrew L Simon et al.
Sruthi Adimadhyam et al.
Background: Antitumor necrosis factor (anti-TNF) inhibitors are first-line treatment among patients with ulcerative colitis (UC). With time, patients tend to lose response or become intolerant, necessitating switching to ...
Comparative Study
Inflammatory bowel diseases. 2024 Apr 3;30(4):554-562. DOI:10.1093/ibd/izad115 2024
Geography Influences Susceptibility to SARS-CoV-2 Serological Response in Patients With Inflammatory Bowel Disease: Multinational Analysis From the ICARUS-IBD Consortium [0.03%]
地理位置影响炎症性肠病患者SARS-CoV-2血清学反应的易感性：来自ICARUS-IBD联盟的跨国分析
Serre-Yu Wong,Judith Wellens,Drew Helmus et al.
Serre-Yu Wong et al.
Background: Beyond systematic reviews and meta-analyses, there have been no direct studies of serological response to COVID-19 in patients with inflammatory bowel disease (IBD) across continents. In particular, there has ...
Observational Study
Inflammatory bowel diseases. 2023 Nov 2;29(11):1693-1705. DOI:10.1093/ibd/izad097 2023
SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis [0.03%]
SIRT3激活剂Honokiol抑制Th17细胞分化并缓解结肠炎
Xiaotian Chen,Mingming Zhang,Fan Zhou et al.
Xiaotian Chen et al.
Background: Honokiol (HKL), a natural extract of the bark of the magnolia tree and an activator of the mitochondrial protein sirtuin-3 (SIRT3), has been proposed to possess anti-inflammatory effects. This study investigat...
Attenuated Expression of SLCO2A1 Caused by DNA Methylation in Pediatric Inflammatory Bowel Disease [0.03%]
DNA甲基化导致的小儿科炎症性肠病中SLCO2A1基因表达降低
Natsuki Ito,Takahiro Kudo,Hidetaka Eguchi et al.
Natsuki Ito et al.
Background: SLCO2A1 encodes a prostaglandin (PG) transporter, and autosomal recessive pathogenic variants of this gene cause chronic enteropathy associated with SLCO2A1. It is unclear whether a heterozygous pathogenic var...