Niclosamide Enema for Active Distal Ulcerative Colitis: A Phase 1, Open-Label Study [0.03%]
niclosamide灌肠液治疗活动性远端溃疡性结肠炎患者的I期开放标签研究
Irene Marafini,Elena De Cristofaro,Silvia Salvatori et al.
Irene Marafini et al.
Background: Oral and rectal formulations of 5-aminosalicylic acid are the first-line therapy for mild-to-moderate, distal ulcerative colitis (UC), but such a treatment is not effective in one-third of patients. Niclosamid...
Clinical Trial
Inflammatory bowel diseases. 2024 Jun 3;30(6):894-899. DOI:10.1093/ibd/izad125 2024
Assessing Progression of Biologic Therapies Based on Smoking Status in Patients With Crohn's Disease [0.03%]
基于吸烟状况评估生物制剂在克罗恩病患者中的疗效及其影响
Madeline Alizadeh,Osman Ali,Raymond K Cross
Madeline Alizadeh
Background: Active smoking is a well-established risk factor for developing Crohn's disease (CD) and negatively impacts overall disease progression. Patients who start or continue smoking after CD diagnosis are at risk fo...
Feasibility, Acceptability, and Preliminary Efficacy of Acceptance Commitment Therapy for Adults Living With Inflammatory Bowel Disease and Distress [0.03%]
成人炎症性肠病患者的接纳承诺疗法的可行性、可接受性和初步疗效研究
Daniel Romano,Susan Chesterman,Matthew Fuller-Tyszkiewicz et al.
Daniel Romano et al.
Background: The bidirectional relationship between inflammatory bowel disease (IBD) flare-ups and depression/anxiety symptoms has prompted investigations into psychotherapy to improve health-related quality of life (HRQoL...
Randomized Controlled Trial
Inflammatory bowel diseases. 2024 Jun 3;30(6):911-921. DOI:10.1093/ibd/izad122 2024
Prediction of Response to Systemic Corticosteroids in Active UC by Microbial Composition-A Prospective Multicenter Study [0.03%]
基于微生物组成预测活动期溃疡性结肠炎患者对系统性皮质类固醇治疗反应的前瞻性多中心研究
Andreas Blesl,Philipp Wurm,Silvio Waschina et al.
Andreas Blesl et al.
Background: Corticosteroids are used for induction of remission in patients with moderately to severely active ulcerative colitis. However, up to one-third of patients fail to this therapy. We investigated if fecal microb...
Multicenter Study
Inflammatory bowel diseases. 2024 Jan 5;30(1):9-19. DOI:10.1093/ibd/izad126 2024
HLA-DQA1*05 Was Not Associated With Primary Nonresponse or Loss of Response to First Anti-TNF in Real-World Inflammatory Bowel Disease Patients [0.03%]
HLA-DQA1*05不与炎症性肠病患者初始抗TNF应答缺失或继发失应答相关
Andrea Pascual-Oliver,Diego Casas-Deza,Camila Cuarán et al.
Andrea Pascual-Oliver et al.
Background: We lack predictors of response to biologics in the management of patients with inflammatory bowel disease (IBD). A recent study has shown a significant association between HLA-DQA1*05 carriers and the developm...
Machine Learning-based Characterization of Longitudinal Health Care Utilization Among Patients With Inflammatory Bowel Diseases [0.03%]
基于机器学习的炎症性肠病患者纵向医疗利用特征研究
Berkeley N Limketkai,Laura Maas,Mahesh Krishna et al.
Berkeley N Limketkai et al.
Background: Inflammatory bowel disease (IBD) is associated with increased health care utilization. Forecasting of high resource utilizers could improve resource allocation. In this study, we aimed to develop machine learn...
Multicenter Study
Inflammatory bowel diseases. 2024 May 2;30(5):697-703. DOI:10.1093/ibd/izad127 2024
LAMB3 Promotes Intestinal Inflammation Through SERPINA3 and Is Directly Transcriptionally Regulated by P65 in Inflammatory Bowel Disease [0.03%]
LAMB3通过SERPINA3促进肠道炎症并直接受到炎性肠病中P65转录调控
Fangyuan Liu,Weimin Xu,Yaosheng Wang et al.
Fangyuan Liu et al.
Background: Various extracellular matrix (ECM) reshaping events are involved in inflammatory bowel disease (IBD). LAMB3 is a vital subunit of laminin-332, an important ECM component. Data on the biological function of LAM...
NAFLD Is Associated With Quiescent Rather Than Active Crohn's Disease [0.03%]
非酒精性脂肪肝与沉默型而非活动型克罗恩病相关
Scott McHenry,Matthew Glover,Ali Ahmed et al.
Scott McHenry et al.
Background and aims: Crohn's disease (CD) confers an increased risk of nonalcoholic fatty liver disease (NAFLD), but the pathogenesis remains poorly understood. We determined if active intestinal inflammation increases th...
Excessive Mitochondrial Fission Suppresses Mucosal Repair by Impairing Butyrate Metabolism in Colonocytes [0.03%]
线粒体过度分裂通过损害结肠上皮细胞丁酸盐代谢抑制黏膜修复功能
Shi-Chen Fu,Jun-Yan Qu,Li-Xiang Li et al.
Shi-Chen Fu et al.
Background: Mucosal healing is one of the principal therapeutic targets for ulcerative colitis (UC). Mitochondria are dynamic organelles that undergo constant fusion and fission; however, the process that is most conduciv...
Shubha Bhat,Benjamin Click,Miguel Regueiro
Shubha Bhat
The recent approval of new medications with novel mechanisms of action and emergence of updated safety information for existing therapies has changed the treatment landscape of inflammatory bowel disease (IBD). These advances led to unique ...