CircASPH Enhances Exosomal STING to Facilitate M2 Macrophage Polarization in Colorectal Cancer [0.03%]
圆盘状ASPH增强外泌体STING以促进结直肠癌中M2型巨噬细胞极化
Yuting Zhang,Jiakun Guo,Liyin Zhang et al.
Yuting Zhang et al.
Exosomes are considered a mediator of communication within the tumor microenvironment (TME), which modulates cancer progression through transmitting cargos between cancer cells and other cancer-related cells in TME. Circular RNAs (circRNAs)...
Efficacy of Ustekinumab Optimization by 2 Initial Intravenous Doses in Adult Patients With Severe Crohn's Disease [0.03%]
乌司奴单抗优化治疗重度克罗恩病成人患者的有效性：首次静脉注射两次用药的疗效分析
Haixia Ren,Jian Kang,Jing Wang et al.
Haixia Ren et al.
Background: Although increasing studies have reported that dose escalation can improve treatment response to ustekinumab in patients with Crohn's disease (CD), their strategies mainly focus on maintenance regimen. Evidenc...
All-or-Nothing Behavior and Catastrophic Thinking Predict Fatigue in Inflammatory Bowel Disease: A Prospective Cohort Study [0.03%]
全有或全无的行为方式和灾难性思维预示炎症性肠病患者的疲劳：一项前瞻性队列研究
Calum D Moulton,Cheryl Jordan,Bu&#x;Hussain Hayee et al.
Calum D Moulton et al.
1-Year Comparison of Clinical and Endoscopic Outcomes of Tofacitinib vs Vedolizumab for Ulcerative Colitis After Anti-Tumor Necrosis Factor Failure: A Real-World Cohort Study in the United States [0.03%]
一项真实世界队列研究：美国抗TNF治疗失败的溃疡性结肠炎患者接受托法替尼与维多珠单抗一年后的临床和内镜结果比较
Rahul S Dalal,Puza P Sharma,Kanwal Bains et al.
Rahul S Dalal et al.
Nationwide Real-World Exclusive Enteral Nutrition Practice Over Time: Persistence of Use as Induction for Pediatric Crohn's Disease and Emerging Combination Strategy With Biologics [0.03%]
长期的全国真实世界-exclusive enteral nutrition实践：作为儿科克罗恩病诱导治疗的持续使用以及与生物制剂联合策略的出现
David I F Wands,Laura Gianolio,David C Wilson et al.
David I F Wands et al.
Background: Exclusive enteral nutrition (EEN) is the recommended first-line induction treatment in pediatric patients with active luminal Crohn's disease (CD). We aimed to provide a nationwide overview of evolving EEN pra...
Corticosteroids but not Anti-TNF Are Associated With Increased COVID-19 Complications in Patients With Inflammatory Bowel Disease [0.03%]
皮质类固醇而非抗TNF与炎症性肠病患者COVID-19并发症增加有关
Millie D Long,Lauren Parlett,James D Lewis et al.
Millie D Long et al.
Background and aims: Immunosuppressed individuals are at higher risk for COVID-19 complications, yet data in patients with inflammatory bowel disease (IBD) are limited. We evaluated the risk of COVID-19- severe sequelae b...
Pouch Body Anastomotic Ulcerations Are Not Associated With an Increased Risk of Pouchitis [0.03%]
造口吻合溃疡与增加的 pouchitis 风险无关
Marouf Hossain,Michael Plietz,Sergey Khaitov et al.
Marouf Hossain et al.
Chen Hasya Zinger,Yehuda Ringel,Mayan Eitan et al.
Chen Hasya Zinger et al.
Micronutrient Status and Prediction of Disease Outcome in Adults With Inflammatory Bowel Disease Receiving Biologic Therapy [0.03%]
生物制剂治疗炎症性肠病成人患者微量营养素状态与疾病结局的预测
Emily Brownson,Jayne Saunders,Aleksandra Jatkowska et al.
Emily Brownson et al.
Background and aims: Micronutrient deficiencies are common in patients with inflammatory bowel disease (IBD), but whether they relate to disease outcomes remains unknown. This study assessed the micronutrient status of ad...
Extensive Colitis and Smoking Are Associated With Postoperative Complications Within 30 Days of Ileal Pouch-Anal Anastomosis [0.03%]
广泛结肠炎和吸烟与回肠储袋肛管吻合术后30天内并发症相关
Edward L Barnes,Scott Esckilsen,Jean Ashburn et al.
Edward L Barnes et al.
Background: Our understanding of outcomes after proctocolectomy with ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC) is largely based on analyses of selected populations. We created a state-level registry ...