Serum and Histologic Eosinophilia as a Predictive Biomarker of Response to Mirikizumab in Ulcerative Colitis [0.03%]
血清和组织嗜酸性粒细胞增多作为溃疡性结肠炎对米奎珠单抗治疗反应的预测生物标志物
Emily C L Wong,Parambir S Dulai,John K Marshall et al.
Emily C L Wong et al.
Introduction: Eosinophils may contribute to ulcerative colitis (UC) pathogenesis through inflammation and epithelial injury. Mirikizumab, a selective IL-23 inhibitor, has shown efficacy in moderate-to-severe UC. However, ...
Shova Subedi,Lindsey G Albenbergl,Julie A Bass et al.
Shova Subedi et al.
Safety and Efficacy of Ozanimod in Patients With Moderately to Severely Active Ulcerative Colitis Stratified by Age [0.03%]
奥扎莫德治疗中至重度活动性溃疡性结肠炎的疗效和安全性（按年龄分层）
Adam S Faye,David T Rubin,Corey A Siegel et al.
Adam S Faye et al.
Background: Older adults with ulcerative colitis (UC) have unique treatment challenges. Ozanimod is approved for the treatment of moderately to severely active UC in adults based on the phase 3 True North (TN) study resul...
Differences in Anti-αvβ6 Integrin Antibody Expression between U.S. and Japanese Cohorts in Inflammatory Bowel Disease [0.03%]
美国和日本炎症性肠病队列中抗αvβ6整合素自身抗体表达的差异
Yoichi Kakuta,Dalin Li,Philip Debbas et al.
Yoichi Kakuta et al.
Background: Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn's disease (CD), have complex pathologies requiring precise diagnostic tools. We evaluated the clinical utility of anti-integrin ...
Artificial Intelligence as a New Player in Dietary Management of Inflammatory Bowel Disease [0.03%]
人工智能在炎症性肠病饮食管理中的作用
Pavan Vemulakonda,Valerie S Stark,Anushka Deogaonkar et al.
Pavan Vemulakonda et al.
A Collection of Patient-Derived Intestinal Organoid Lines Reveals Epithelial Phenotypes Associated with Genetic Drivers of Pediatric Inflammatory Bowel Disease [0.03%]
一组患者来源的肠类器官系揭示了与儿童炎症性肠病遗传驱动因素相关的上皮表型
Zahra Shojaei Jeshvaghani,Carmen Argmann,Maaike H de Vries et al.
Zahra Shojaei Jeshvaghani et al.
Background: Pediatric Inflammatory Bowel Disease (IBD) is a chronic condition characterized by persistent intestinal inflammation in children. It often presents with distinct clinical phenotypes and is more frequently lin...
Mucosal B Cell Expansion and Maturation Contribute to Colitis Pathogenesis [0.03%]
黏膜B细胞的增殖和成熟对结肠炎发病有影响
Ivan C N Fung,Pim J Koelink,Lieven G M Mulders et al.
Ivan C N Fung et al.
Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing and remitting mucosal inflammation of the colon. While active UC mucosa is characterized by dysregulated B cell respon...
Association of Geography With Screening and Development of Cervical Neoplasia in Those With Inflammatory Bowel Disease [0.03%]
地理位置与炎症性肠病患者宫颈癌筛查和宫颈病变发展的相关性分析
Quinn Goddard,Stephanie Coward,Cynthia H Seow et al.
Quinn Goddard et al.
Background: While cancer risk is elevated in inflammatory bowel disease (IBD), results are less clear for cervical cancer. Screening has made cervical cancer relatively preventable, but geography impacts access, possibly ...
Nationwide Analysis of Food Insecurity among Individuals with Inflammatory Bowel Disease in the United States [0.03%]
美国炎症性肠病患者的食物不安全状况分析
Mark R Baniqued,Alexandra C Greb,Neha D Shah et al.
Mark R Baniqued et al.
Background: Diet impacts symptoms and inflammation in inflammatory bowel disease (IBD), but limited food access restricts options and hampers adherence to diets that may help in the management of IBD. This study aims to m...
Exploring Gut Mucosal Microbiota to Distinguish Crohn's Disease from Intestinal Tuberculosis [0.03%]
探究肠道黏膜微生态区分克罗恩病和肠结核
Ajith C Kuriakose,Dilip Abraham,Blossom Benny et al.
Ajith C Kuriakose et al.
We studied the mucosal bacterial population in patients with active Crohn's disease and intestinal tuberculosis. Significant differences were noted in the composition and predicted function of the gut microbiota between the two conditions. ...