Low-Dose Aspirin and the Prevention of Colorectal Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study [0.03%]
柳氮磺胺吡啶对炎症性肠病患者结直肠癌预防效果的前瞻性队列研究
Yan-Jiun Huang,Jui-An Lin,Wan-Ming Chen et al.
Yan-Jiun Huang et al.
Background: Patients with inflammatory bowel disease (IBD) are at increased risk of colorectal cancer (CRC). However, the chemopreventive role of aspirin remains uncertain due to conflicting findings in prior studies. ...
Efficacy, Safety, and Pharmacokinetics of Golimumab in Children with Moderately-To-Severely Active Ulcerative Colitis: Results from the PURSUIT 2 Study [0.03%]
戈利木单抗治疗中重度活动性溃疡性结肠炎儿童患者的疗效、安全性及药代动力学：PURSUIT 2研究结果
Dan Turner,Kathleen G Lomax,Gigi Veereman et al.
Dan Turner et al.
Background: Golimumab is an anti-TNFα biologic agent that has been approved for adults with moderately-to-severely active ulcerative colitis (UC). We investigated the efficacy, safety, and pharmacokinetics (PK) of golimu...
The Role of Autophagy in Inflammatory Diseases: Challenges and Therapeutic Potential [0.03%]
自噬在炎症性疾病中的作用：挑战与治疗潜力
Ana M Múnera-Rodríguez,Camila Leiva-Castro,Icíar Reina-Pérez et al.
Ana M Múnera-Rodríguez et al.
Autophagy is a crucial cellular process involved in the degradation of cytoplasmic components through lysosomal machinery. It is essential for maintaining cellular homeostasis and responding to various stressors. Autophagy has emerged as a ...
B Cell Dysregulation in IBD: From Pathophysiology to Therapeutic Targeting [0.03%]
炎症性肠病中B细胞的失调节：从病理生理到治疗靶点
Divya Jha,Saurabh Mehandru
Divya Jha
Real-World Implementation of Treat to Target in Patients With IBD in a Learning Health System: An IBD Qorus Collaborative Study [0.03%]
学习型卫生系统中针对IBD患者的靶向治疗的现实世界实现：来自IBD Qorus合作研究的结果
Siddharth Singh,Brant J Oliver,Jason K Hou et al.
Siddharth Singh et al.
Background: We examined real-world utilization of treat-to-target (TTT) strategies and conducted a quality improvement (QI) project to improve uptake of TTT strategies in a learning health system, IBD Qorus. ...
CRUCIAL Insights From a Decade Long Retrospective National Audit of Total Abdominal Colectomy Outcomes for Ulcerative Colitis [0.03%]
溃疡性结肠炎回肠储袋切除术十年全国回顾审计的宝贵见解
Ian J B Stephens,Brenda Murphy,Lucy Burns et al.
Ian J B Stephens et al.
Background: Total abdominal colectomy (TAC) is a key surgical intervention for patients with ulcerative colitis (UC), particularly in the setting of acute severe disease or medically refractory colitis. While internationa...
Surgical management of small bowel adenocarcinoma in Crohn disease: a multicenter retrospective analysis [0.03%]
克罗恩病患者小肠腺癌的外科治疗：多中心回顾性分析
Tommaso Violante,Davide Ferrari,Matteo Rottoli et al.
Tommaso Violante et al.
Background: Patients with Crohn disease (CD) face an elevated risk of developing small bowel adenocarcinoma (SBA), a malignancy characterized by late-stage diagnosis and poor prognosis. In this study we aimed to character...
Pregnancy and Maternal Outcomes After Exposure to Risankizumab During Pregnancy: A Multi-Center Experience in the United States [0.03%]
妊娠期间暴露于瑞沙珠单抗对母体结局的影响——美国多中心经验
Rachel W Winter,Liang-Yin Tao,Sonia Friedman et al.
Rachel W Winter et al.
Unmasking a New Trauma in Inflammatory Bowel Disease: Unequal Psychological Burden [0.03%]
揭穿炎症性肠病的新创伤：不平等的心理负担
Sara Massironi,Silvio Danese
Sara Massironi
Inflammatory bowel disease-related post-traumatic stress disproportionately affects Black and Latino/a patients and is driven by traumatic disease experiences, cumulative adversity, and unmeasured medication effects. Recognition of these fa...
The Chicago Mesenteric Fat Index: A Novel Metric for Point-of-Care Intestinal Ultrasound Evaluation of Mesenteric Fat Wrapping in Crohn's Disease [0.03%]
克罗恩病肠系膜脂肪浸润点-of-护理肠道超声评估的新指标：芝加哥肠系膜脂肪指数(CMFI)
Joëlle St-Pierre,Amelia Kellar,Tessa George et al.
Joëlle St-Pierre et al.
Background: Mesenteric fat (MF) wrapping is a characteristic feature of Crohn's disease (CD). Current assessment methods are limited to binary classification (presence/absence), restricting their utility in assessing dise...