Subcutaneous infliximab in pediatric inflammatory bowel disease: Sustained remission, predictable pharmacokinetics, and real-world US implementation [0.03%]
儿科炎症性肠病的皮下注射英夫利昔单抗：持续缓解、可预测的药代动力学和真实世界的美国实施经验
Patricia M Hughes,Nanci Pittman,Keith Benkov et al.
Patricia M Hughes et al.
Objectives: Subcutaneous infliximab (IFX-SC) offers a convenient alternative to intravenous infliximab (IFX-IV) in inflammatory bowel disease (IBD) with more stable concentrations. Pediatric experience remains limited. We...
Exclusive enteral nutrition containing transforming growth factor-β improves intestinal barrier function in a colitis mouse model [0.03%]
含有转化生长因子-β的 exclusive enteral营养改善colitis小鼠模型的肠道屏障功能
Kawthar Boumessid,Vickie Lacroix,Ekaterina Ovtchinnikova et al.
Kawthar Boumessid et al.
Objectives: Exclusive enteral nutrition (EEN) is the first-line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the...
Dyssynergic defecation in adolescents with constipation: Anorectal manometry findings [0.03%]
青少年便秘的协同性排便障碍：肛直肠测压结果
Mustafa Sadek,Alaa Almallouhi,Olla Darwish et al.
Mustafa Sadek et al.
Objectives: To describe and compare anorectal manometry findings in constipated adolescents with and without dyssynergic defecation (DD). Methods: ...
The illusion of competence: Evaluating the clinical reasoning of large language models in pediatric gastroenterology [0.03%]
胜任的错觉：评估大型语言模型在儿科胃肠病学中的临床推理能力
Yasin Maruf Ergen,Selçuk Teke,Edibe Gözde Başaran et al.
Yasin Maruf Ergen et al.
Objective: To evaluate the diagnostic accuracy and clinical reasoning of three frontier large language models (LLMs) across standardized pediatric gastroenterology, hepatology, and nutrition (PGHN) clinical vignettes. ...
Does diagnosis by biopsy versus serology-only affect follow-up in celiac disease? [0.03%]
活检与仅使用血液检测诊断的乳糜泻患者随访方式是否不同？
Maria Cristina Pacheco,Kai Kokesh,Jane Dickerson et al.
Maria Cristina Pacheco et al.
Objectives: Serology-only diagnosis of celiac disease is increasing, but few recent studies have looked at the outcomes of patients undergoing this approach. The aim of this study was to evaluate difference in clinical fo...
Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls [0.03%]
急性胰腺炎和克罗恩病患儿的肠道微生物组与肠易激综合征及健康对照组的比较研究
Neha R Santucci,Chinenye R Dike,Jenny Hellmann et al.
Neha R Santucci et al.
Objectives: Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized t...
Early discharge after paediatric liver biopsy: A prospective observational study [0.03%]
儿科肝活检后的早期出院：一项前瞻性观察研究
Fie Brantbjerg Tinning,Jakob Stensballe,Birthe Henriksen et al.
Fie Brantbjerg Tinning et al.
Objective: To evaluate the safety of early discharge after percutaneous liver biopsy (PLB) in children using prospective bleeding risk stratification. Met...
An interpretable machine learning model for outpatient referral risk assessment in pediatric biliary atresia after Kasai portoenterostomy [0.03%]
一种关于卡萨伊肝肠吻合术后儿童胆道闭锁门诊转诊风险评估的可解释机器学习模型
Yanran Zhang,Xingyuan Ke,Jiaying Liu et al.
Yanran Zhang et al.
Objectives: To develop an interpretable model using routine outpatient data to assist risk stratification and referral assessment in children with biliary atresia (BA) after Kasai portoenterostomy (KPE). ...
Clinical and genetic features of pediatric hereditary polyposis syndromes in Israel: A nationwide multicenter cohort [0.03%]
以色列儿童遗传性息肉病综合征的临床和基因特征：一项全国多中心队列研究
Shlomi Cohen,Tal Cozacov,Ilana Weintraub et al.
Shlomi Cohen et al.
Objectives: Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long-term risk of malignancy. Current data on their presentation, management, and outcomes...