The pharmacokinetics and safety of vonoprazan in adolescents and children with gastroesophageal reflux disease [0.03%]
伏诺拉赞在青少年和儿童胃食管反流病患者中的药代动力学和安全性研究
Darcy J Mulford,David A Gremse,Yu-Ming Chang et al.
Darcy J Mulford et al.
Objectives: Vonoprazan, a potassium-competitive acid blocker, provides more rapid, potent, and durable elevations in gastric pH than proton pump inhibitors in adults and may be a treatment option for adolescents and child...
Anne H Lafeber,Mark Bosch,Dewi van Harskamp et al.
Anne H Lafeber et al.
Objectives: Moderate and late preterm infants (MLPTI, gestational age 32 0/7-36 6/7 weeks) have altered body composition compared to term-born infants, but data beyond infancy are lacking. This study aimed to assess body ...
Left-sided portal hypertension with gastrointestinal bleeding in paediatric solid pseudopapillary neoplasm of pancreas [0.03%]
左叶门脉高压并发消化道出血的儿童实性假乳头状瘤胰腺癌1例报告
Sarthak Chakrabarti,Yash Shrivastava,Itish Patnaik
Sarthak Chakrabarti
Biomarkers for feeding intolerance in infants with complex heart defects undergoing palliation surgery [0.03%]
复合型心脏畸形外科姑息手术后喂养不耐受的生物标志物研究
Katarzyna Bigaj,Alvaro Coronado Munoz,Yuying Liu et al.
Katarzyna Bigaj et al.
Objectives: We evaluated whether serum biomarkers reflecting intestinal membrane integrity will serve as predictors for post-operative feeding intolerance (FI) in patients with congenital heart disease (CHD). ...
Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States [0.03%]
美国多中心托法替尼治疗难治性儿童炎症性肠病的体会
Denise D Young,Jennifer E Murphy,Mallory Chavannes et al.
Denise D Young et al.
Objectives: Tofacitinib is a selective Janus kinase (JAK-1) inhibitor approved for the treatment of ulcerative colitis (UC) in adults. Data is limited in the pediatric population. The aim of this study was to evaluate the...
Longitudinal changes in vibration-controlled transient elastography in pediatric fatty liver disease [0.03%]
儿童非酒精性脂肪肝病振动控制瞬时弹性图的纵向变化
Katherine F Sweeny,Citlali Aguilera-Rico,Christina Chan et al.
Katherine F Sweeny et al.
Objectives: There is a lack of research describing changes in vibration-controlled transient elastography (VCTE) parameters in pediatric metabolic dysfunction-associated steatotic liver disease (MASLD). We hypothesized th...
A novel diagnostic serum protein signature for pediatric inflammatory bowel disease [0.03%]
儿童炎症性肠病的新型诊断血清蛋白标志物
Charlotte Bache-Wiig Mathisen,Niklas Nyström,Igor Bazov et al.
Charlotte Bache-Wiig Mathisen et al.
Objectives: Diagnostic delay is common in pediatric inflammatory bowel disease (PIBD), and fecal calprotectin (FCP) is often limited by challenges with sample collection. Therefore, we aimed to identify and validate a blo...
Early immunosuppression therapy improves outcomes in CD8+ T-cell activated paediatric acute liver failure and hepatitis [0.03%]
早期免疫抑制治疗可改善儿童急性肝功能衰竭和肝炎伴CD8+T细胞活化患者的预后
Prerna Diksha,Winita Hardikar,Mark Oliver et al.
Prerna Diksha et al.
Objectives: Paediatric acute liver failure (PALF) and hepatitis of indeterminate aetiology with distinctive CD8+ T-cell rich liver infiltrates is a recently recognised disorder of immune-mediated dysregulation. We aimed t...
Risk factors at diagnosis for progression to severe colitis and colectomy in children and young adult patients with mild-moderate disease [0.03%]
儿科及青年人群中初诊轻至中度溃疡性结肠炎患者进展为重度结肠炎和结肠切除术的风险因素分析
Karine Amirikian,Jaeun Choi,Xianhong Xie et al.
Karine Amirikian et al.
Objectives: Pediatric ulcerative colitis (UC) has a more severe and unpredictable course than adult-onset disease. This study aimed to identify baseline and time-varying risk factors for the development of severe disease ...
Performance of large language models in answering frequently-asked questions on celiac disease [0.03%]
大型语言模型回答乳糜泻常见问题的性能
Nadav Peled,Dror S Shouval,Peter Gillett et al.
Nadav Peled et al.
Objectives: Celiac disease (CeD) is a common autoimmune condition requiring lifelong adherence to a gluten-free diet (GFD). Patients and caregivers increasingly seek information online, and large language models (LLMs) ha...