Therapeutic Drug Monitoring of Thiopurines in Patients With Inflammatory Bowel Disease: Observations From Daily Practice [0.03%]
治疗炎症性肠病患者的硫嘌呤药物监测：每日实践中的观察
Mila Lovrić,Kristina Dukić,Silvija Čuković-Čavka et al.
Mila Lovrić et al.
Background: Patients with inflammatory bowel disease (IBD) to be treated with thiopurines should undergo preemptive genotyping for reduced-function thiopurine methyltransferase (TPMT) polymorphisms. Therapeutic drug monit...
Dalbavancin Pharmacokinetics in an 18-Month-Old Child Undergoing Extracorporeal Membrane Oxygenation: A Short Communication [0.03%]
接受体外膜氧合的18月大儿童的达巴万星药代动力学：简讯
Alessia Cafaro,Giammarco Baiardi,Alessio Mesini et al.
Alessia Cafaro et al.
Extracorporeal membrane oxygenation (ECMO) is a life-saving support for patients with severe respiratory or cardiac failure. During ECMO support, the pharmacokinetics of drugs is often affected. Therapeutic drug monitoring of antimicrobial ...
Effect of Augmented Renal Clearance and Febrile Neutropenia on Initial Trough Level and Clearance of Teicoplanin [0.03%]
肾小球滤过率增加和中性粒细胞减少发热对替考拉宁初始谷浓度和清除率的影响
Nozomi Kondo,Ryota Tanaka,Ryosuke Tatsuta et al.
Nozomi Kondo et al.
Background: Augmented renal clearance (ARC) and febrile neutropenia (FN) increase drug clearance primarily through glomerular filtration. In this study, we evaluated the influence of ARC and FN on dose-normalized trough c...
Simultaneous Monitoring of 3 Antiviral Drugs in Serum Using Liquid Chromatography-Tandem Mass Spectrometry: Full Validation and Clinical Application [0.03%]
液相色谱-串联质谱法同时检测血清三种抗病毒药物的浓度：全面验证及临床应用
Laura Conesa,Gonzalo Gonzalez-Silva,Lydia Peris-Serra et al.
Laura Conesa et al.
Background: Patients undergoing solid organ and hematopoietic stem cell transplantation are at risk of opportunistic pathogenic infections that increase morbidity and mortality. Universal antiviral prophylaxis improves th...
External Validation of Population Pharmacokinetic Models of Lamotrigine in Patients with Epilepsy or Postneurosurgery [0.03%]
拉莫三嗪在癫痫或术后患者的群体药代动力学模型的外部验证研究
Yunshu Jia,Jin Guo,Hua Yang et al.
Yunshu Jia et al.
Background: This study aimed to evaluate the predictive performance of published lamotrigine (LTG) population pharmacokinetic (PPK) models using an external data set of Chinese patients with epilepsy or postneurosurgery. ...
Impact of UGT1A4 Polymorphisms on the Posaconazole Serum Trough Concentrations in Patients with Acute Myeloid Leukemia Receiving Delayed-Release Tablets [0.03%]
UGT1A4基因多态性对接受缓释片治疗的急性髓系白血病患者泊沙康唑谷浓度的影响
François Parant,Marie-Claude Gagnieu,Laurie Di-Pilla et al.
François Parant et al.
Background: Posaconazole (PCZ) is recommended for antifungal prophylaxis in neutropenic patients with acute myeloid leukemia (AML). Although the delayed-release (DR) tablet of PCZ has better bioavailability than the oral ...
Serum Lenvatinib Concentration Monitoring in a Patient With Thyroid Cancer Exhibiting Hand-Foot Syndrome: A Case Report [0.03%]
出现手足综合症的甲状腺癌患者血清乐伐替尼浓度监测一例报告
Yusuke Watanabe,Kosuke Doki,Ikuo Sekine et al.
Yusuke Watanabe et al.
Background: Hand-foot syndrome (HFS) is a common adverse event associated with lenvatinib treatment. Lenvatinib dose adjustment using therapeutic drug monitoring may be beneficial in the management of HFS, as symptoms imp...
Prospective Validation of a Nomogram for Determining the Optimal Dose of Lamotrigine for Augmentation Therapy in Patients With Treatment-Resistant Depression [0.03%]
前瞻性验证用于确定难治性抑郁症患者增效治疗拉莫三嗪的最佳剂量的诺模图
Takeshi Suzuki,Goyo Nagai,Kazuo Mihara et al.
Takeshi Suzuki et al.
Background: Previous research has shown that a plasma lamotrigine concentration of 12.7 µmol/L may be a threshold for a good therapeutic response to lamotrigine augmentation therapy in Japanese patients with treatment-re...
Bridging the Gap: Advancing Pharmacogenetic Testing Through Comprehensive Implementation and Evaluation Strategies [0.03%]
弥合差距：通过全面实施和评估策略推进药理基因组学检测
Sara Rogers,Patrick J Silva,Kenneth Ramos
Sara Rogers
Pharmacogenomics (PGx) enhances drug therapy by tailoring treatment to individual genetic profiles, thereby improving safety and efficacy. However, the integration of PGx into clinical practice, particularly in hospitals, faces significant ...