Exploring Health Care Professionals' Engagement With a Precision Dosing Calculator and Supporting Clinical Information: Insights From an Eye-Tracking and Usability Study [0.03%]
探索医疗专业人员与精准给药计算器及支持性临床信息互动的情况：来自眼动性和易用性研究的见解
Sherilyn Wong,Philip R Selby,Michael B Ward et al.
Sherilyn Wong et al.
Background: Pharmacokinetic-based dosing calculators for individualized drug dosing remain underutilized in clinical practice, often due to poor usability and a lack of user-centered design. Understanding how health care ...
Pharmacokinetic Study of Carboplatin Using Various Overweight-Correcting Dosing Algorithms and Biomarkers in Patients With Varying BMI Categories [0.03%]
基于不同BMI分类的患者使用各种肥胖矫正给药算法和生物标志物的卡铂药代动力学研究
Mart P Kicken,Corine Bethlehem,Karin Beunen et al.
Mart P Kicken et al.
Background: The Cockcroft-Gault (CG) formula is more likely to overestimate renal function and carboplatin dosing in patients who are overweight. In this prospective pharmacokinetic study, the use of an adjusted Cockcroft...
Ceftobiprole in Critically Ill Patients: Proposal for New Dosage Regimens [0.03%]
重症患者使用头孢比罗的新给药方案的提出
Sarah Baklouti,Camille Mané,Youssef Bennis et al.
Sarah Baklouti et al.
Background: Ceftobiprole is a broad-spectrum cephalosporin. It is currently approved for the treatment of community- and hospital-acquired pneumonia. However, the recommended dosage regimen of ceftobiprole may not be suff...
Patient With Probable Invasive Pulmonary Aspergillosis and Idiopathic Bilateral Chylothorax With Chylopericardium May Experience Unachievable Therapeutic Voriconazole Serum Levels [0.03%]
疑似侵袭性肺曲霉病并发原发性双侧乳糜胸和乳糜心包的患者可能出现无法实现的伏立康唑血药浓度治疗水平
Vichapat Tharanon,Apirat Muangkasem,Nicharee Inprasit et al.
Vichapat Tharanon et al.
Voriconazole (VRZ) is an effective first-line treatment for invasive pulmonary aspergillosis. This case report aims to describe the unachievable therapeutic VRZ serum levels in a patient with probable invasive pulmonary aspergillosis and id...
Massive Lamotrigine Intoxication Refractory to Sodium Bicarbonate Treatment: Grand Round/A Case Study [0.03%]
大剂量拉莫三嗪中毒对碳酸氢盐治疗无反应：大查房/病例研究
Catalina Forteza,Juan Ignacio Brisa,Isabel Gomila et al.
Catalina Forteza et al.
Background: Acute lamotrigine (LTG) overdose can cause refractory cardiac arrhythmias, hypotension, altered mental status, and seizures. Here, we present the case of a patient admitted for massive LTG intoxication refract...
Development and Clinical Validation of a Volumetric Absorptive Capillary Microsampling Method for Quantification of Mycophenolic Acid and Mycophenolic Acid Glucuronide in Kidney Transplant Recipients [0.03%]
用于量化肾移植受者的霉酚酸和霉酚酸葡萄糖醛酸的体积吸量毛细管取样法的发展及临床验证
Ole Martin Drevland,Eline Skadberg,Lan Anh Tran et al.
Ole Martin Drevland et al.
Background: Mycophenolic acid (MPA) is a cornerstone of immunosuppressive treatment in kidney transplant recipients (KTRs). Traditional therapeutic drug monitoring for MPA is based on venous blood sampling. Finger-prick c...
A Bayesian Framework for Optimizing Amikacin Therapy in Critically Ill Patients With Cancer [0.03%]
用于优化危重症癌症患者的阿米卡星治疗的贝叶斯框架
Priscila Akemi Yamamoto,Leyanis Rodriguez-Vera,João Paulo Telles et al.
Priscila Akemi Yamamoto et al.
Background: Amikacin (AMK) is used to treat gram-negative bacterial infections in intensive care unit (ICU) patients. However, its narrow therapeutic range and high interindividual variability can lead to toxicity and ine...
Upadacitinib Optimization in a Patient With Protein-Losing Enteropathy Secondary to (Transient) Nonocclusive Mesenteric Ischemia, Idiopathic Myointimal Hyperplasia, and Hemodialysis: Grand Round [0.03%]
用于治疗肠道缺血和原发性肠淋巴管扩张症患者的优代西替尼优化：病例讨论
Johannes A Kroes,Michiel D Voskuil,Erin H Smeijsters et al.
Johannes A Kroes et al.
Background: We report a case of a 19-year-old man with severe total parenteral nutrition-dependent protein-losing enteropathy who was treated with upadacitinib. Treatment was complicated by renal failure requiring hemodia...
External Evaluation of Population Pharmacokinetic Models of Ustekinumab in Patients with Inflammatory Bowel Disease [0.03%]
乌司奴单抗治疗炎症性肠病患者的群体药代动力学模型外部评价
Carles Iniesta-Navalón,Manuel Ríos Saorín,Juan Manuel Neira-Torrecillas et al.
Carles Iniesta-Navalón et al.
Background: Population pharmacokinetic (popPK) models are essential tools for optimizing ustekinumab (UST) dosing for the treatment of inflammatory bowel disease (IBD) through therapeutic drug monitoring. The external val...
Model-Informed Precision Dosing of Vancomycin in Vietnamese Children: Innovative Midpoint Concentration Monitoring Using 2 Bayesian Programs [0.03%]
越南儿童静脉注射给药的模型提示精准用药：创新使用两点浓度监测和两种贝叶斯程序
Ba Hai Le,Chi Kien Phung,Olivia Yip et al.
Ba Hai Le et al.
Background: Bayesian area under the curve (AUC)-guided vancomycin dosing, preferably with 2 samples (2S), is recommended for pediatric patients. However, the timing of sampling may not always be convenient in the clinical...