Pharmacokinetic and Pharmacodynamic Assessment of Valganciclovir in Infants With Congenital Cytomegalovirus Infection [0.03%]
评价缬更昔洛韦治疗先天性巨细胞病毒感染婴儿的药代动力学和药效学研究
Kotaro Itohara,Kazuhiro Yamamoto,Shunsuke Fujinaka et al.
Kotaro Itohara et al.
Background: Valganciclovir (VGCV) is administered at a dose of 16 mg/kg 2 times daily for 6 months to treat symptomatic congenital cytomegalovirus (CMV) infections. During the treatment period, approximately 20% of the pa...
Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study [0.03%]
急诊科阿米卡星剂量优化：群体药代动力学模拟研究
Nada Dia,Sabrina De Winter,Matthias Gijsen et al.
Nada Dia et al.
Background: In adult patients with sepsis or septic shock admitted to the emergency department, a single intravenous 15 mg/kg amikacin dose provides inadequate pharmacokinetic-pharmacodynamic target attainment at the loca...
Nifedipine May Be an Inhibitor of Clozapine Metabolism as Seen in 5 Patients: 2 From a US Double-Blind Study and 3 From a German Therapeutic Drug Monitoring Study [0.03%]
尼莫地平可能是一个氯氮平代谢抑制剂：5个患者所见的病例，其中美国双盲研究中2例和德国TDM中的3例
Georgios Schoretsanitis,Ekkehard Haen,Hélène Verdoux et al.
Georgios Schoretsanitis et al.
Background: Clozapine is the only licensed antipsychotic for treatment-refractory schizophrenia. Therapeutic drug monitoring (TDM) refers to the measurement of clozapine concentration. Clozapine TDM can be used to optimiz...
Randomized Controlled Trial
Therapeutic drug monitoring. 2025 Jun 1;47(3):438-441. DOI:10.1097/FTD.0000000000001277 2025
Lacosamide Pharmacokinetics and Retention in Japanese Patients With Epilepsy: A Retrospective Study on the Influence of Age, Comedications, and Cytochrome P450 2C19 Polymorphism [0.03%]
拉科沙明在日本癫痫患者中的药代动力学和蓄积：年龄、合并用药及细胞色素P450 2C19多态性影响的回顾性研究
Yoshiaki Yamamoto,Yuka Shiratani,Takuji Nishida et al.
Yoshiaki Yamamoto et al.
Background: This retrospective study aimed to identify the genetic and nongenetic factors that influence serum lacosamide (LCM) concentrations and evaluate the effects of cytochrome P450 2C19 (CYP2C19) polymorphism on the...
Evaluating the Accuracy and Clinical Utility of AFIAS-10 Point of Care Versus Enzyme-Linked Immunosorbent Assay in Therapeutic Drug Monitoring of Infliximab and Adalimumab [0.03%]
评估AFIAS-10即时检测与酶联免疫吸附测定在英夫利昔单抗和阿达木单抗治疗药物监测中的准确性及临床效用
Carles Iniesta-Navalón,Manuel Ríos-Saorín,Rebeca Añez-Castaño et al.
Carles Iniesta-Navalón et al.
Background: New point-of-care (POC) techniques offer rapid results and address some of the limitations of traditional enzyme-linked immunosorbent assay (ELISA) methods, such as lengthy processing times and delays in thera...
Gene Polymorphisms Play an Important Role in the Drug Interaction Between Posaconazole and Tacrolimus in Renal Transplant Patients [0.03%]
基因多态性在肾移植患者泊沙康唑与他克莫司药物相互作用中起重要作用
Nan Hu,Mengmeng Guan,Bin Gu et al.
Nan Hu et al.
Background: Posaconazole (POSA), a second-generation triazole antifungal drug, inhibits CYP3A and P-glycoprotein. Here, the interaction between POSA and tacrolimus (TAC) in patients undergoing early renal transplantation ...
Serum Lenvatinib and Interleukin-6 Profiles and Their Relationship With Acute Heart Failure Development in a Patient With Thymic Carcinoma and Cancer Inflammation [0.03%]
塞来昔布联合雅美罗治疗骨关节炎患者的血清LENVATINIB和IL-6谱型及其与急性心力衰竭发病的相关性研究
Mitsutoshi Asakura,Natsumi Seki,Yasuaki Mino et al.
Mitsutoshi Asakura et al.
Background: A 63-year-old woman diagnosed with unresectable thymic carcinoma received modified ADOC therapy, followed by thoracic radiotherapy. Because she had a poor response to both chemotherapy and radiotherapy, lenvat...
Simultaneous Prediction of Area Under the Curves of Mycophenolic Acid and Its Metabolites and Enterohepatic Recirculation in Kidney Transplant Recipients [0.03%]
同时预测肾脏移植受者的霉酚酸及其代谢产物的曲线下面积和肠肝循环
Moataz E Mohamed,Abdelrahman Saqr,Guillaume Onyeaghala et al.
Moataz E Mohamed et al.
Background: Therapeutic drug monitoring of mycophenolic acid (MPA) is limited due to the requirement for intensive pharmacokinetic sampling to assess the area under the curve (AUC). Limited sampling strategies (LSS) offer...
Risk of Underexposure and Lack of Efficacy of Cefiderocol by Reduced Dosing in Japanese Patients With Gram-Negative Bacterial Infections [0.03%]
剂量减少时头孢地尔在日本感染革兰阴性菌患者中的不足暴露风险和疗效下降问题
Naoya Itoh
Naoya Itoh
Background: Recently, a cost-saving, dose-reducing strategy for cefiderocol against gram-negative bacteria with low cefiderocol minimum inhibitory concentrations (MICs) was proposed as an alternative to the standard dosin...
Utility of a TDM-Guided Expert Clinical Pharmacological Advice Program for Optimizing the Use of Novel Beta-Lactam/Beta-Lactamase Inhibitor Combinations and Cefiderocol in a Tertiary University Hospital: An Interim Analysis [0.03%]
一种TDM指导的专家临床药理咨询项目在三级大学医院优化新型β-内酰胺/ β-内酰胺酶抑制剂组合和头孢地尔应用中的效用：中期分析
Milo Gatti,Pier Giorgio Cojutti,Matteo Rinaldi et al.
Milo Gatti et al.
Background: This study assessed the utility of a therapeutic drug monitoring (TDM)-guided expert clinical pharmacological advice (ECPA) program to optimize aggressive pharmacokinetic/pharmacodynamic (PK/PD) target attainm...