Improvements, Challenges, and the Investigation of Two Unknowns in Arsenic Urine Speciation Analysis by HPLC-ICP-MS: From Development to Post-implementation [0.03%]
高效液相色谱-电感耦合等离子体质谱法进行尿砷形态分析的改进、挑战及两个未知物的剖析：从开发到应用后的研究
Kathryn Smith,Bryce T Genesi,Jessica M Boyd et al.
Kathryn Smith et al.
Background: High-performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) is a critical analytical technique for determining the different forms of arsenic present in human urine. A new...
Deadly Combination of Formic and Sulfuric Acid: 2 Cases of Carbon Monoxide Intoxication [0.03%]
甲酸和硫酸的致死组合：2例一氧化碳中毒事件
Corine Bethlehem,Nanda M van Dam,Linda G W Franken et al.
Corine Bethlehem et al.
Background: Carbon monoxide (CO) poisoning is associated with high morbidity and mortality rates. Although accidental inhalation is the most common cause, suicide through CO from a mixture of formic and sulfuric acids is ...
Delayed Elimination Concentrations of High-Dose Methotrexate in Adults With Hematological Malignancies: To Standardize or Not? A Scoping Review [0.03%]
高剂量甲氨蝶呤成人血液系统恶性肿瘤延迟清除浓度的范围：标准化与否？一项综述研究
Fauziah T,Ai Sim Goh,Noraida Mohamed Shah et al.
Fauziah T et al.
Background: High-dose methotrexate (HDMTX) is a cornerstone therapeutic regimen for hematological malignancies; however, delayed elimination remains a significant clinical challenge. Currently, no standardized definition ...
Twenty Years of Evolution in Toxicology Laboratories: Lessons Learned to Face Upcoming Challenges in Health Care and Society [0.03%]
毒理学实验室二十年的发展历程：吸取经验教训应对医疗和保健领域的新挑战
Souleiman El Balkhi,Eric J F Franssen
Souleiman El Balkhi
To Convert or Not to Convert? Official International Association of Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Considerations and Recommendations for Converting Capillary Blood Microsampling Concentrations to Plasma Concentrations [0.03%]
转换还是不转换？官方国际治疗药物监测和临床毒理学协会指南：将末梢血微量样本浓度转换为血浆浓度的考量与建议
Laura Boffel,Hanna De Baets,Liesl Heughebaert et al.
Laura Boffel et al.
Background: Capillary blood microsampling enables the sampling of small blood volumes, making it suitable for vulnerable populations, remote collection, and repeated sampling. Owing to its minimal invasiveness, blood micr...
Therapeutic Drug Monitoring of Elexacaftor, Tezacaftor, and Ivacaftor: An Overview of Bioanalytical Methods [0.03%]
艾瑞昔芬、-tezacaftor和ivacaftor治疗药物监测：生物分析方法概述
Alessia Cafaro,Sebastiano Barco,Carlo Castellani et al.
Alessia Cafaro et al.
Background: Over the past decade, cystic fibrosis transmembrane conductance regulator (CFTR) modulators have revolutionized the treatment of cystic fibrosis. Currently, 4 modulators are approved for clinical use: ivacafto...
Pyrethroid Exposure in Premature Newborns: A Pilot Study on Materno-Fetal Transmission and Early Postnatal Evolution [0.03%]
早产新生儿的拟除虫菊酯暴露：关于母胎传递和早期出生后演变的初步研究
Pauline Bressin,Souleiman El Balkhi,Chahrazed El Hamel et al.
Pauline Bressin et al.
Objectives: The aims were to investigate the presence of pyrethroid metabolites (MetaPyr) in the urine of mothers and their premature newborns, and assess potential transplacental transmission and the evolution of these c...
Arjen Koppen,Paola Mian,Marieke G G Sturkenboom
Arjen Koppen
Purpose: Given its widespread availability, paracetamol (acetaminophen and p-aminophenol) is frequently ingested in overdose, making paracetamol poisoning one of the most common drug-induced poisonings worldwide. ...
Evaluation of the Real-World Practice of Model-Informed Therapeutic Drug Monitoring and Its Association With Pharmacokinetic Target Attainment Rates: A Large-Scale, Single-Center Retrospective Study [0.03%]
基于药理模型的血药浓度监测实践的真实世界评估及其与血药浓度靶点达标率关联的大样本、单中心回顾性研究
Yoonjin Kim,Jaegu Kang,Jisoo Song et al.
Yoonjin Kim et al.
Background: Model-informed therapeutic drug monitoring (TDM) optimizes drug-dosing regimens using concentration measurements and mathematical models. Despite its importance, the implementation of TDM and pharmacokinetic (...
Broad-Spectrum Drug Screening Positivity Rates in Pediatrics and Adults: The Reference Laboratory Perspective [0.03%]
参考实验室视角下的儿科和成人广谱药物筛查阳性率
Ryan C Shean,Kamisha L Johnson-Davis
Ryan C Shean
Background: Broad-spectrum drug testing is useful in various practical settings, especially when patients present with unknown exposures. Although national poison control data inform trends in toxicity and poison control ...