The Rational Basis for Personalized Treatment Using Concentration-Guided Dosing [0.03%]
基于浓度指导给药的个性化治疗合理化基础
Nick Holford,Zvonimir Petric
Nick Holford
Background: The purpose of the review is to explain and encourage the use of terminology that distinguishes between the steps of measurement and reporting of concentrations, interpretation of the measurements, and subsequ...
Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data [0.03%]
基于集成模型的模拟与真实世界数据预测克罗恩病儿科及青年患者英夫利昔单抗药代动力学的机器学习模型
Kei Irie,Phillip Minar,Jack Reifenberg et al.
Kei Irie et al.
Background: Predicting infliximab pharmacokinetics (PK) is essential for optimizing individualized dosing in pediatric patients with Crohn disease (CD). Machine learning (ML) has emerged as a tool for predicting drug expo...
Exploring the Role of Toxicogenetics in Understanding Discrepancies Between Blood Concentrations and Clinical Outcomes in 3- Methylmethcathinone Intoxications [0.03%]
探究毒基因组学在理解3-甲基甲基卡西酮中毒情况下血液浓度与临床结局之间差异中的作用
Guillaume Drevin,Antoine Baudriller,Marie Briet et al.
Guillaume Drevin et al.
Stabilization of Abiraterone in Human Plasma Using the Esterase Inhibitor Bis(4-nitrophenyl) Phosphate: A Short Communication [0.03%]
用人血浆中的酯酶抑制剂双(4-硝基苯基)磷酸酯结合稳定阿比特龙：简讯
Maaike A C Bruin,Luc Lucas,Jos H Beijnen et al.
Maaike A C Bruin et al.
Background: Abiraterone, an active metabolite of abiraterone acetate, is used for the treatment of prostate cancer. Therapeutic drug monitoring (TDM) of abiraterone could improve treatment outcomes. However, its stability...
A Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Monitoring Plasma l-Asparaginase Activity in Pediatric Patients With Acute Lymphoblastic Leukemia Receiving Pegaspargase Treatment [0.03%]
用于接受培门冬酶治疗的儿童急性淋巴细胞白血病患者监测血浆l-天冬氨酶活性的新液相色谱-串联质谱法
Hengyi Yu,Qun Hu,Lu Liu et al.
Hengyi Yu et al.
Background: Acute lymphoblastic leukemia (ALL) is the predominant malignancy in pediatric patients. As a crucial constituent of ALL chemotherapy, l-asparaginase is recognized as an integral element of treatment with a thr...
Methadone Serum Concentration Monitoring in Palliative Care Patients with Cancer-Induced Bone Pain: A Short Communication [0.03%]
癌性骨痛姑息治疗患者的美沙酮血药浓度监测：简讯
Robert Wojnar,Merlina Sulistio,Alexandra Gorelik et al.
Robert Wojnar et al.
Background: Therapeutic drug monitoring of methadone for opioid replacement therapy in the management of opioid dependence is well-described. However, only a few studies have described the correlation between serum methad...
Potential Role of Therapeutic Drug Monitoring in Preventing Antibiotic-Induced Neuropsychiatric Disorders: A Narrative Review [0.03%]
治疗药物监测在预防抗生素所致神经精神障碍中的潜在作用：叙事综述
Dario Cattaneo,Davide Fiore Bavaro,Michele Bartoletti
Dario Cattaneo
Background: Neuropsychiatric toxicity is a common adverse effect of antibiotics. Advanced age, renal insufficiency, high drug doses, and prolonged therapy are relevant risk factors, suggesting that this event might be cau...
Therapeutic Drug Monitoring of Beta-Lactams in Cystic Fibrosis: Unattained Target in Standard Antibiotic Dosing: A Case Study [0.03%]
囊性纤维化患者β-内酰胺类药物的治疗药物监测：常规抗生素给药无法实现的目标：一项病例研究
Eliska Maraczek Markova,Nela Stastna,Libor Fila et al.
Eliska Maraczek Markova et al.
Acute exacerbations of cystic fibrosis (CF) diminish quality of life and, if inadequately treated, can be life-threatening. The pathophysiological alterations associated with CF result in modified antibiotic pharmacokinetics. Moreover, the ...
Validation of an Automated Urea Assay Method Using Bronchoalveolar Lavage Fluid Samples for the Therapeutic Drug Monitoring of Antimicrobials in Severe Pneumonia [0.03%]
重症肺炎抗菌药物血药浓度监测的支气管肺泡灌洗液自动化尿素测定方法验证研究
Maeva Ghaleb,Julia Delomez,Chloé Sauzay et al.
Maeva Ghaleb et al.
Background: Determining the concentration of an antimicrobial agent in epithelial lining fluid using therapeutic drug monitoring (TDM) may be clinically useful for optimizing drug exposure in patients with severe pneumoni...
Need for Systematic and Comprehensive Toxicological Screening Protocols in Pediatric Poisoning Cases [0.03%]
儿童中毒病例中系统而全面的毒理学筛查方案的需求
Guillaume Drevin,Marie Briet,Séverine Férec et al.
Guillaume Drevin et al.